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Ben Heineike

@heineikeb.bsky.social
45 followers 81 following 26 posts
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Reposted by Ben Heineike
Pedro Beltrao @pedrobeltrao.bsky.social · 04/03/2026
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...
evocellnet.com
Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration
We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...
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Ben Heineike @heineikeb.bsky.social · 18/03/2026
Proud of our new paper just out in the @genetics-gsa.bsky.social's #GENETICS journal academic.oup.com/genetics/adv...!
academic.oup.com
Genetic and environmental determinants of multicellular-like phenotypes in fission yeast
Abstract. Multicellular fungi have repeatedly given rise to primarily unicellular yeast species. Some of these, including the fission yeast Schizosaccharom
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Ben Heineike @heineikeb.bsky.social · 01/08/2025
Nice new paper by Mariella Obermaier in the Ralser Lab to understand interactions between common drugs co-administered with antifungals and antifungals on C. albicans pubmed.ncbi.nlm.nih.gov/40720257/
pubmed.ncbi.nlm.nih.gov
Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in Candida albicans - PubMed
<span><b>Introduction.</b> Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifunga...
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Ben Heineike @heineikeb.bsky.social · 25/07/2025
Nice work by @maxhaase.bsky.social about the strange history of yeast centromeres - got to see him present it at #yeast2025
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Reposted by Ben Heineike
Max Haase @maxhaase.bsky.social · 25/04/2025
It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...
biorxiv.org
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
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Reposted by Ben Heineike
🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10/07/2025
NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus! www.nature.com/articles/s41... #alphafold #evolution #genomics
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Ben Heineike @heineikeb.bsky.social · 10/07/2025
A paper I have been working on with Oliver Lemke in the Ralser lab has just come out: www.nature.com/articles/s41... We used predicted structures to gain insight into the evolution of metabolic proteins in yeast. A bit more in this linked-in post (www.linkedin.com/posts/benjam...).
nature.com
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
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Reposted by Ben Heineike
liti_nice @litinice.bsky.social · 03/07/2025
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)
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