Nature Reviews Immunology, Published online: 28 September 2026; doi:10.1038/s41577-026-01362-7A study in Immunity reports that protease allergens ‘train’ sensory neurons through metabolic remodelling to enhance the response to re-exposure.

Hawkins et al. introduce the Single-Cell Pediatric Cancer Atlas: a uniformly processed collection of sc/snRNA-seq data from pediatric cancer samples and models. 700 samples from 55 pediatric cancer ty...

Cre recombination is a widely used technique for mechanistic insights in physiology and disease. However, available constitutive and inducible Cre systems present challenges that can be prohibitive...

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Our mission is to advance the health and wellness of our diverse communities throughout Massachusetts and across the world by leading and innovating in education, research, health care delivery and pu...

A distinct lymphoid progenitor generates RORγt+ DCs via a REV-ERB–controlled RORγt enhancer and PRDM16–PU.1-transcriptional programs.

Comprehensive pan-cancer analysis of loss of the Y chromosome (LOY) in benign and malignant cells establishes a new model linking LOY in circulating and tumour-infiltrating immune cells to LOY in...

Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Republicans on spending committee push back against proposed reorganization and overhead cuts

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Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II+ cells at single-cell …

Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...

Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

Nature - A coordinated cellular network regulates tolerance to food

Mucosal Immunology Podcast · Episode

While debates in the U.S. rage about potential overexposure to fluoride, people worldwide still lack basic access to it.

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.

The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.

Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bon…

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...