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Owkin

@owkin.bsky.social
175 followers 16 following 59 posts

Understand complex biology through agentic AI. Learn more at owkin.com

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Owkin @owkin.bsky.social · 24/09/2026
IMILIA is accepted at COMPAYL, MICCAI 2026. Our interpretable MIL framework predicts IBD inflammation from H&E WSIs, and HistoPLUS quantifies the cells in each slide's top-scoring tiles. Used directly as risk scores, those counts reach ROC-AUC up to 0.97. arxiv.org/abs/2512.13440
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Owkin @owkin.bsky.social · 16/09/2026
🎙️ Ulrich Keilholz, Director of Charité Comprehensive Cancer Center, joins our VP of Product Jonas Béal on our podcast to discuss how we build expert biomedical skills with leading academics and how Ulrich’s expertise in systems medicine can become an AI skill. Full podcast: youtu.be/PPfw78-SFvA
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Owkin @owkin.bsky.social · 04/09/2026
We benchmarked K Pro vs Claude on Anthropic’s BioMysteryBench. TLDR: K Pro has same accuracy, greater reliability. Discover the full benchmark 👉 www.owkin.com/blog/how-doe...
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Owkin @owkin.bsky.social · 03/09/2026
HistoPLUS is now peer-reviewed in the Journal of Pathology Informatics, open access. New in the published version: cell features from H&E alone predict FGFR3 mutation status in bladder cancer at AUC 0.80 (n=290, TCGA-BLCA) vs 0.57 for the clinical baseline. doi.org/10.1016/j.jp...
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Owkin @owkin.bsky.social · 02/09/2026
Announcing a new agreement between Owkin & @boehringerglobal.bsky.social to license K Pro, our AI Scientist, together w/multimodal data from Owkin's patient data network. 👉🏼 www.owkin.com/newsfeed/owkin-to-license-k-pro-ai-scientist-and-multimodal-oncology-and-immunology-data-to-boehringer-ingelheim
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Owkin @owkin.bsky.social · 19/08/2026
ssGSEA across 320 MOSAIC NSCLC patients — 214 adenocarcinoma, 106 squamous — five Hallmark signatures scored per sample, violin plots by subtype. MYC targets up in squamous, consistent with 3q26. Three minutes end to end. 👉 Watch it run
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Owkin @owkin.bsky.social · 12/08/2026
Pseudobulk DEA in K Pro, our AI Scientist. On the public CELLxGENE breast cancer atlas: 1 malignant + 1 non-malignant profile per patient, DESeq2 across 16,623 genes → 6,033 sig. markers. In under 3 min. 🤖 Then, in 1 line: "restrict to TNBC, raise logFC to 2." No code required. 👉 Watch it run
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Owkin @owkin.bsky.social · 05/08/2026
Biomarker extraction in K Pro, our AI Scientist. One prompt on our MOSAIC bladder cohort: split patients into high vs low survival and find the 3 features that best separate them (metastatic-at-diagnosis patients excluded). 🤖 T4 disease ~4× more common in low-OS. ~3 min. 👉 Watch it run
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Owkin @owkin.bsky.social · 03/08/2026
🎙️ Antoine Yver, physician-scientist and Sanofi board member joins our Head of Product Jonas Béal on the Owkin podcast to discuss where AI is genuinely moving the needle in oncology drug development. Watch the podcast here —> youtu.be/wp_raOdBV7I
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Owkin @owkin.bsky.social · 23/07/2026
We gave a group of builders an open brief and two days with K Pro. What they decided was worth building says something about where they thought AI for biology tools fall short. We wrote it up → www.owkin.com/blog/what-was-built-at-the-rewiring-biology-hackathon
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Owkin @owkin.bsky.social · 11/07/2026
🚀 Day 1 of Rewiring Biology is underway in San Francisco. Teams are getting their hands on K Pro and the building has begun. Good luck to all participants, stay tuned for more. www.owkin.com/connect/rewi...
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Owkin @owkin.bsky.social · 09/07/2026
"AI in biology only works when it understands context, learns iteratively, and is built hand-in-hand with the scientists who use it." From our Zurich dinner: why the next frontier is parallel science and data built with the people who use it. Recap → www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 06/07/2026
Our latest technical blog "A Practical Map of Evaluation for Agentic Systems" talks about agentic eval for K Pro, our AI Scientist, across tool calls, trajectory, and end-to-end intent: www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 30/06/2026
Following Anthropic’s announcements at The Briefing: AI for Science 2026 event today, including Claude Science, Anthropic’s AI workbench for scientists, we are excited to share that our agentic platform, K Pro, currently reasons through frontier models, including Claude.
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Owkin @owkin.bsky.social · 29/06/2026
Whole-slide images in oncology: incredible data, painful workflow. Download heavy files, switch to separate viewers, switch back to run your models. K Pro's new interactive viewer lets you explore slides in fullscreen, right inside your analysis session. www.owkin.com/k-os/k-pro
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Owkin @owkin.bsky.social · 26/06/2026
One COX2-driven axis suppresses T cells, NK cells, cDC1s, and the myeloid compartment simultaneously, through a single cAMP-dependent mechanism. New Owkin blog: the mechanistic case for triple EP2/EP4/DP1 blockade with OKN4395. www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 22/06/2026
⏳ 10 days left to apply for Rewiring Biology. Spots going fast. San Francisco, July 11–12. If you've been thinking about it, now's the time. Apply: luma.com/4s2r63rg
luma.com
🧬 Rewiring Biology Hackathon by Owkin · Luma
Rewiring Biology Hackathon July 11 - July 12, 2026 | San Francisco, California Join us for a two day hackathon where ML engineers, AI scientists, and…
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Owkin @owkin.bsky.social · 15/06/2026
🚀 Applications open for Rewiring Biology — Owkin's SF hackathon, July 11–12. 50 spots for frontier builders working on AI tools for biomedical research. Apply: luma.com/4s2r63rg
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Owkin @owkin.bsky.social · 29/05/2026
We spoke with Yann Flereau, Co-founder & CEO of Blossom Lifesciences, about what turns hypotheses into biological truth. The hardest part isn’t generating ideas — it’s finding the right signal and having the data to validate it. That’s where rigorous validation matters most.
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Owkin @owkin.bsky.social · 28/05/2026
Over the past few weeks we shared notes on building target ID into K Pro and testing it on our bladder cancer program: the honest metric (PR-AUC), the bias trap (ERBB2 for everything), the attrition funnel (314 → 1). Here's the full blog tying it together: www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 18/05/2026
🔬 New preprint: PRDX5, an atypical peroxiredoxin, is upregulated in epithelioid malignant pleural mesothelioma. Using ML to identify cryptic allosteric pockets + a 3.6M-compound virtual screen: 36 non-covalent inhibitors, 8% hit rate, sub-µM potency. www.biorxiv.org/content/10.6...
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Owkin @owkin.bsky.social · 13/05/2026
📢 Announcing our new deal to build AI agents as part of a multi-year K Pro license agreement with @astra-zeneca.bsky.social Read the full press release here - www.owkin.com/newsfeed/owk...
Owkin to build AI agents as part of K Pro license agreement with AstraZeneca
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Owkin @owkin.bsky.social · 30/04/2026
Peer-reviewed in BMC Med Research Methodology: our benchmark of 9 subgroup analysis methods for time-to-event RCTs finds interaction tests best for detecting heterogeneity, ML-based CATE estimators best for identifying good responders. link.springer.com/article/10.1...
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Owkin @owkin.bsky.social · 29/04/2026
AACR 2026 confirmed AI's central role in cancer research. From foundation models like Apollo to agentic systems, the field is moving from passive tools to active collaborators. Our recap on the three waves of AI in oncology — and where the real bottleneck now lies: www.owkin.com/blogs-case-s...
owkin.com
From foundation models to AI scientists: Inside oncology's AI shift at AACR 2026
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Owkin @owkin.bsky.social · 19/04/2026
🎤 We're at AACR 2026 — stop by booth 4616 to meet the team and try K Pro demos. On Monday April 20, join Dr. Caroline Hoffmann and Jonas Béal for our spotlight: "AI Agent for Pharma R&D: Powering nextgen drug discovery & development". See you there!
Owkin at AACR 2026
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Owkin @owkin.bsky.social · 07/04/2026
90% of ADC trials fail because we've been asking the wrong question. Not "is the target there?" but "WHERE is it, WHAT is it interacting with, and HOW will the TME respond?" Owkin's spatial biology-first approach uses MOSAIC data + K Pro to design next gen ADCs www.owkin.com/blogs-case-s...
owkin.com
Beyond the Magic Bullet: Why the Future of ADCs is Written in Spatial Biology
Discover our blog to see beyond the magic bullet and why the future of ADCs is written in spatial biology.
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Owkin @owkin.bsky.social · 02/04/2026
New preprint: AI agents that learn from experimental feedback for iterative perturbation discovery. Agents receiving results after each round found 166% more gene-phenotype hits than random (29.3 vs 11, p=0.003). 📄 arxiv.org/abs/2603.26177 📄 www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 31/03/2026
Preprint: CytoSyn, a foundation diffusion model for histopathology. Generates diverse and highly realistic synthetic tissue images using H0-mini’s embeddings as conditioning. Benchmark shows our models reach state-of-the-art FID. Paper: arxiv.org/abs/2603.18089 Model: huggingface.co/Owkin-Biopti...
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Owkin @owkin.bsky.social · 19/03/2026
Preprint on bioRxiv: Multi-modal benchmarking of Ultima UG100 vs Illumina across snRNA-seq, WTS, WES, WGS on FFPE samples. UG100 shows high concordance with Illumina for oncogenic/immune signals, with characteristic indel profile but enhanced precision Preprint: www.biorxiv.org/content/10.6...
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Owkin @owkin.bsky.social · 20/01/2026
Published in Nat Commun: MISO uses local attention transformers to predict spatial gene expression from H&E at near single-cell res. Trained on MOSAIC samples. Outperforms existing methods. In collaboration with FFCD. Paper: www.nature.com/articles/s41... Code: github.com/owkin/miso_c...
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Owkin @owkin.bsky.social · 23/12/2025
We're donating PyDESeq2 to @scverse.bsky.social for long-term maintenance & development. Python reimplementation of DESeq2, ecosystem member since 2023, now in the hands of one of the best open source communities in omics. Good science requires good open source. github.com/scverse/PyDE...
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Owkin @owkin.bsky.social · 22/12/2025
Our new blog explores OwkinZero, a language model fine-tuned on 300,000+ biological Q&A pairs using RLVR. Compact models that outperform larger commercial models on biological inference. Teaching AI to understand mechanisms: www.linkedin.com/posts/owkin_...
linkedin.com
Teaching AI to Reason About Biology: Beyond Facts to Mechanisms | OWKIN
How do you teach AI to reason about biology, not just retrieve facts? In 2025, we built the model to do exactly that: 🧠 OwkinZero: a language model fine-tuned specifically for biological reasoning 🔬...
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Owkin @owkin.bsky.social · 18/12/2025
Spatial omics generates rich multimodal data, but extracting biological insights requires infrastructure at scale. Our new blog covers the 2025 data engine. All building toward BASI. Read more: www.linkedin.com/pulse/buildi...
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Owkin @owkin.bsky.social · 17/12/2025
We introduce IMILIA: interpretable Multiple Instance Learning for IBD inflammation prediction from H&E WSIs. Combines H0-mini, HistoPLUS, and EpiSeg to automatically derive quantitative inflammatory markers. Preprint on arXiv: arxiv.org/abs/2512.13440
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Owkin @owkin.bsky.social · 07/11/2025
Published in Scientific Reports: SarcNet uses federated AI to forecast metastatic relapse in STS, achieving 0.797 AUC. Dive deeper: www.nature.com/articles/s41...
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Owkin @owkin.bsky.social · 05/11/2025
We’re releasing CytoSyn, our new diffusion model for synthetic histopathology image generation. REPA-E architecture. H0-mini conditioning. Model: huggingface.co/Owkin-Biopti... Supporting article: www.owkin.com/blogs-case-s...
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Owkin @owkin.bsky.social · 04/11/2025
Discover OKN4395 at #SITC2025—Poster #1169. A triple inhibitor overcoming tumor immunosuppression by targeting EP2, EP4, DP1. Learn more about OKN4395 at epkin.ai
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Owkin @owkin.bsky.social · 30/10/2025
Our new multimodal ML models achieve high accuracy in predicting iCCA outcomes (c-index 0.70). This collaborative study with @mskcancercenter.bsky.social enhances understanding of the disease and may guide treatment selection. Check out the paper: www.sciencedirect.com/science/arti...
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Owkin @owkin.bsky.social · 28/10/2025
We dived into cancer cell interactions with COMPOTES. Using MOSAIC data, we uncovered 45 programs across major cancers, shedding light on immune dynamics and therapeutic paths. Pre-print at: doi.org/10.1101/2025...
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Owkin @owkin.bsky.social · 23/10/2025
We used ML & multimodal data to find glioblastoma biomarkers linked to long survival. Our model (AUC 0.85), trained on @ap-hp.bsky.social data, reveals tissue regions predicting survival. Model interpretation & biological insights from MOSAIC’s GBM cohort. Pre-print: www.biorxiv.org/content/10.1...
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Owkin @owkin.bsky.social · 22/10/2025
📢 New on bioRxiv: We developed SpaMIL, a novel Multiple Instance Learning (MIL) framework for predicting patient-level outcomes from spatial transcriptomics data. Read the preprint: www.biorxiv.org/content/10.1...
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Owkin @owkin.bsky.social · 02/04/2025
K Navigator launches on May 6th - introducing the scientific literature tool, K-literature, tailored to scientific research, featuring: 📑 26.5+ million papers 🧠 Natural language input 👥 Hallucination limitation K Navigator is free to use for academic researchers. www.owkin.com/k-os/owkin-k...
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Owkin @owkin.bsky.social · 13/03/2025
🕹️ How fast can you reach K? Play the game as we get ready to launch K Navigator, a free agentic AI co-pilot boosting the productivity of biology research and breakthroughs across the world. Try it now: Google Play → play.google.com/store/apps/d... App Store → apps.apple.com/fr/app/first...
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Owkin @owkin.bsky.social · 13/03/2025
Excited to share our latest research on a novel approach for controlling the sensitivity of whole-slide image classification models in digital pathology, using the TSM (Tile Score Matching) method. Read the full pre-print: arxiv.org/abs/2502.20144
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Owkin @owkin.bsky.social · 06/03/2025
💥 Owkin K Navigator launches on the 6th of May. Our free-to-use agentic AI co-pilot for researchers across the world, to enhance the productivity of biological research and drive breakthrough discoveries. Kountdown to K begins now. Sign up here → www.owkin.com/k-os/owkin-k
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Owkin @owkin.bsky.social · 27/02/2025
We're launching a comprehensive multimodal patient data discovery program with 20 leading healthcare institutions across France, Spain, Germany, Italy, the US, the UK, and Israel to accelerate medical research by breaking down data silos. Read more at → www.owkin.com/newsfeed/owk...
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Reposted by Owkin
10x Genomics @10xgenomics.bsky.social · 18/02/2025
Join us for a webinar, co-hosted with @owkin.bsky.social, on "Harnessing spatial biology & AI to develop targeted therapeutic strategies." Learn how Owkin is using spatial & AI to optimize development of antibody-drug conjugate strategies & generate novel hypotheses: bit.ly/4jVbQZr
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Owkin @owkin.bsky.social · 14/02/2025
After an eventful #AIActionSummit, our SVP, Head of Public Affairs & Impact Yedidia Levy-Zauberman unpacks Owkin’s key moments in our latest blog - from a high-impact glioblastoma hackathon to recognition by President Emmanuel Macron. 📕 Read the blog → www.owkin.com/blogs-case-s...
owkin.com
Driving innovation in AI for healthcare: Owkin at the AI Action Summit
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Reposted by Owkin
Xosé M Fernández @xosegb.bsky.social · 08/02/2025
A comprehensive evaluation of histopathology foundation models for ovarian cancer subtype classification www.nature.com/articles/s41... @owkin.bsky.social
nature.com
A comprehensive evaluation of histopathology foundation models for ovarian cancer subtype classification - npj Precision Oncology
npj Precision Oncology - A comprehensive evaluation of histopathology foundation models for ovarian cancer subtype classification
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Owkin @owkin.bsky.social · 11/02/2025
Can AI help Pharma speed up drug development? World Street Journal features our CEO Thomas Clozel alongside Aviv Regev from Genentech, AstraZeneca's Chief Data Scientist Jim Weatherall, and GSK's Senior Director of ML and AI Patrick Schwab. 📰 Read the WSJ article → www.wsj.com/tech/ai/phar...
wsj.com
Pharma Companies Turn to AI to Speed Up Drug Development, But Hit Hurdles
Access to data and to skills specific to AI are among the key challenges pharma companies face to unlock the technology’s potential.
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