Telomeres are essential for genome integrity, but the accurate, high-resolution mapping of their three-dimensional (3D) chromatin interactions, a process thought to mediate gene regulation and telomer...

Tang et al. apply spatiotemporal multi-omics to define four proteomic subtypes of IDH-mutant astrocytoma. They highlight an immune/mesenchymal-enriched (IME) subtype marked by gemistocytic differentiation, immune infiltration, and poor prognosis. Their AI-powered toolbox, GUIDE, enables multi-omics-based classification and supports precision diagnostics in glioma care.

Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

The Verhaak lab in the Department of Neurosurgery at the Yale School of Medicine is looking to recruit a postdoctoral associate who will help us develop new therapeutic approaches to treat patients wi...

Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...