Peter Koo @pkoo562.bsky.social · 23/05/2025Excited to share an update to D3 (DNA Discrete Diffusion) — an application of score-entropy discrete diffusion model for regulatory genomics! 🧬 Paper: biorxiv.org/content/10.110… (See thread below 👇) (1/n) 2195
Peter Koo @pkoo562.bsky.social · 23/05/2025Regulatory DNA is characterized by a severe class imbalance: most positions are uninformative, while important signals are sparse and short (e.g., TF motifs). As a result, standard language modeling struggles—its loss is dominated by reconstructing the uninformative positions 2/n 100
