🧬 What do deep-learning models for proteins actually learn?
Our new review looks at how model predictions relate to fitness, folding stability and function.
With @cwjpugh.bsky.social, Mafalda Dias & @jonnyfrazer.bsky.social
🔗 chemrxiv.org/doi/full/10....
chemrxiv.org
From sequences and structures to fitness, folding and function: challenges in the age of AI | ChemRxiv
Deep-learning models have transformed our ability to predict the phenotypic effects
of sequence perturbations. Protein language models (pLMs) score the evolutionary propensity
of any amino-acid substi...
