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carlafolgado.bsky.social

@carlafolgado.bsky.social

Reposted by @carlafolgado.bsky.social

Instituto de Biomedicina de Valencia (IBV), CSIC @ibv-csic.bsky.social · 13/08/2026

🔬 Cada quinasa tiene sus propios “interruptores” Un preprint co-liderado por Antoni Beltran (IBV-CSIC) y Ben Lehner analiza +160.000 mutaciones en 5 quinasas y revela una arquitectura alostérica propia. 📄 Trabajo de Carla Folgado, A. Beltran y B. Lehner 🔗 www.biorxiv.org/content/10.6... #IBVCSIC

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Reposted by @carlafolgado.bsky.social

Ben Lehner @benlehner.bsky.social · 09/08/2026

Conservation and divergence in the allosteric architectures of five human protein kinases. Excited to share our new preprint by @carlafolgado.bsky.social @tonibeltran.bsky.social @sangerinstitute.bsky.social @crg.eu @ibv-csic.bsky.social www.biorxiv.org/content/10.6...

biorxiv.org

Conservation and divergence in the allosteric architectures of five human protein kinases

Protein kinases are central to biological regulation, dysregulated in many diseases, and the targets of a hundred clinically-approved drugs. Structural conservation of kinase active sites makes the de...

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