Viral vectors delivered through the brain glymphatics achieve widespread targeting of glial cells.

IGF-I plays an important role in oligodendrocyte survival and myelination. We used human recombinant IGF-I to

mori is a new R package for sharing R objects across processes via OS-level shared memory. Parallel workers get zero-copy, lazy ALTREP access to the same physical pages — share once, read anywhere.

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.

In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without compromising explanatory power.

Specialized σ factors interact with nuclease-dead, CRISPR–Cas12f proteins to form potent, RNA-guided gene activation systems that function independently of fixed promoter motifs.

Preclinical modeling of human IgG–based drugs is enhanced through humanized Fcγ receptor and FcRn expression in a murine knockin model.

Glass, Matoba, et al. demonstrate that human cortical organoid cell-type proportions, cross-sectional area growth, and cell cycle genes in early neural progenitors are associated with inter-individual variability in infant cortical surface area measurements, supporting the fidelity of organoids as a model system.

Human Genomics - Transcriptome analysis is essential to dissect the molecular mechanisms underlying phenotypic differences and disease mechanisms. Traditionally, microarrays were used, but RNA...

Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the expression of these genes.

H3K79me and H3K36me3 synergistically dampen gene expression to facilitate cellular differentiation.

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...

Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie exercise’s protective ef...

Columbia scientists have found that boosting the performance of a self-cleansing system in the brain flushed amyloid and tau toxins from the brains of mice and improved cognition.

Accelerate model deployment with Databricks and Orbital for R and Python Scikit-learn/Tidymodels projects.

We’re happy to announce that we’re supporting Typst by funding one of their full-time engineers.