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Jon Marles-Wright

@jmarlesw.bsky.social
547 followers 371 following 32 posts

Scientist, husband to @lislowe, father. Views my own. He/him.

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Jon Marles-Wright @jmarlesw.bsky.social · 21/09/2026
Starting off my 29th Fresher’s week with a proud supervisor moment. Congratulations to Imogen for successfully defending her PhD thesis. Thanks to Wyatt Yue and Paul James for examining and a special thanks to Dennis the support dog!
A photograph of a PhD candidate, their examiners, and supervisor.
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Jon Marles-Wright @jmarlesw.bsky.social · 15/09/2026
Congratulations.
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Jon Marles-Wright @jmarlesw.bsky.social · 03/09/2026
I cannot emphasise enough the value of sharing your raw data. The high-res cargo analysis was only possible because we published our previous data on the H. ochraceum encapsulin and the team @cryosparc.bsky.social picked it up and developed a tutorial for non-point group averaging. Cheers to them!
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Jon Marles-Wright @jmarlesw.bsky.social · 03/09/2026
This structure came from Zak McIver's PhD, with assistance from Jenn Ross and Marta Cozzaglio and expert data collection assistance from @allostericstate.bsky.social.
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Jon Marles-Wright @jmarlesw.bsky.social · 03/09/2026
We accidentally stumbled on the Rhodospirillum rubrum encapsulin when we hosted a summer student in the lab in Edinburgh. Didi, a PhD student with Dave Clarke, picked them up and ran with the encapsulated ferritin, but it took us a while to get the full structure of the encapsulin.
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Jon Marles-Wright @jmarlesw.bsky.social · 03/09/2026
Starting off the new academic year with publication a long time in the making: doi.org/10.1016/j.js... The high-resolution analysis of the cargo couldn't have been achieved without us publishing previous raw data and a great tutorial from the team @cryosparc.bsky.social.
Graphical abstract depicting the single particle reconstruction of the R. rubrum encapsulin and its ferritin cargo.
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Augustinas Silale @augustsilale.bsky.social · 02/05/2026
Our study on Bacteroides iron piracy is now out in @pnas.org. We show how surface-exposed lipoproteins bind xenosiderophores with different iron-chelating chemistries and propose a mechanism for xenosiderophore import across the outer membrane. Lots of structures (mostly X-ray this time)!
doi.org
Structural basis of iron piracy by human gut Bacteroides | PNAS
Iron is an essential element that can be growth-limiting in microbial communities, particularly those present within host organisms. To acquire iro...
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Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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Charles Winterhalter @winterhalterlab.bsky.social · 29/04/2026
What are the genetic and molecular determinants underpinning the repair of bidirectional replication fork collapse in bacteria? PhD position open in my lab in collaboration with the brilliant @heathmurraylab.bsky.social. Please share and contact me if interested: www.findaphd.com/phds/project...
findaphd.com
Identifying bacterial DNA repair requirements enabling stable genetic inheritance during bidirectional replication fork collapse at Newcastle University on FindAPhD.com
PhD Project - Identifying bacterial DNA repair requirements enabling stable genetic inheritance during bidirectional replication fork collapse at Newcastle University, listed on FindAPhD.com
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Jon Marles-Wright @jmarlesw.bsky.social · 25/04/2026
Happy April 25th all who celebrate. Light jacket season is upon us.
media.tenor.com
a woman is holding a microphone and wearing a sash that says ' rhol ' on it
ALT: a woman is holding a microphone and wearing a sash that says ' rhol ' on it
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Lis Lowe @lislowe.bsky.social · 27/03/2026
We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem
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Tracy Palmer @proftracypalmer.bsky.social · 23/01/2026
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
findaphd.com
Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com
PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com
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Kate Beckham @kshbeckham.bsky.social · 23/01/2026
BBSSRC (NEEDL) funded PhD studentship in my lab co-supervised by @thecopperdoctor.bsky.social and @mycobacterium-ncl.bsky.social If you're interested in structural biology and membrane transport processes, check out www.findaphd.com/phds/project... deadline 27th of Feb! Get in touch for more info
findaphd.com
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Jon Marles-Wright @jmarlesw.bsky.social · 23/01/2026
Exciting CASE funded PhD opportunity available in the NEEDL PhD programme with me and Thomas Howard: eur03.safelinks.protection.outlook.com?url=https%3A...
eur03.safelinks.protection.outlook.com
Synthetic Biology for Light-Activated Smart Materials. at Newcastle University on FindAPhD.com
PhD Project - Synthetic Biology for Light-Activated Smart Materials. at Newcastle University, listed on FindAPhD.com
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Eugene Valkov @eugenevalkov.bsky.social · 18/01/2026
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
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Chris H. Hill @chillzaa.bsky.social · 06/01/2026
🚨Last chance to apply for two PhD projects in my lab, applying structural biology and single molecule biophysics to investigate gene expression in RNA viruses: www.findaphd.com/phds/?Keywor...
findaphd.com
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Kate Beckham @kshbeckham.bsky.social · 14/12/2025
www.nature.com/articles/s41...
nature.com
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
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Harry Low’s Lab @lowlab.bsky.social · 05/12/2025
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
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Ariane Briegel @arianebriegel.bsky.social · 18/11/2025
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
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Pei Cing Ng @notplastocyanin.bsky.social · 14/11/2025
Proud and excited to see my first, first-author paper out on @pnas.org! Huge thank you to Jon @jmarlesw.bsky.social, Luning and my colleagues for their amazing guidance throughout. www.pnas.org/doi/10.1073/...
pnas.org
Structure and encapsulation of carbonic anhydrase within the α-carboxysome | PNAS
Carboxysomes in cyanobacteria and certain proteobacteria enable efficient CO2 fixation by encapsulating ribulose-1,5-bisphosphate carboxylase/oxyge...
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Jon Marles-Wright @jmarlesw.bsky.social · 14/11/2025
Amazing. Congratulations.
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Tanmay Bharat @tbharat-lab.bsky.social · 13/11/2025
Assembly, architecture and functional roles of microbial surface layers Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social. S-layers are everywhere! www.nature.com/articles/s41...
nature.com
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
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Jon Marles-Wright @jmarlesw.bsky.social · 13/11/2025
Thanks Paula.
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Jon Marles-Wright @jmarlesw.bsky.social · 13/11/2025
Thanks John. Also for the working link!
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Jon Marles-Wright @jmarlesw.bsky.social · 13/11/2025
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
An illustration of a carbonic anhydrase complex in a synthetic mini-carboxysome
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TJ McCorvie @allostericstate.bsky.social · 11/11/2025
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
biorxiv.org
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
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Prof Paula Salgado @pssalgado.bsky.social · 06/11/2025
Afternoon starts with former #Salgadolab student @adamcrawshaw.bsky.social getting the audience engaged on #microcrystals and @diamondlightsource.bsky.social VMXm beamline.
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Newcastle University Structural Biology Facility @nusbf.bsky.social · 06/11/2025
Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!
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Prof Paula Salgado @pssalgado.bsky.social · 05/11/2025
A great overview of #cryoEM in Newcastle from @jmarlesw.bsky.social at #NorthernEye opening @nusbf.bsky.social
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Newcastle University Structural Biology Facility @nusbf.bsky.social · 05/11/2025
Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium
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Jon Marles-Wright @jmarlesw.bsky.social · 04/11/2025
Looking forward to catching up tomorrow.
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TJ McCorvie @allostericstate.bsky.social · 21/10/2025
Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye: nusbf.ncl.ac.uk/ccpem-tfs-ne... The symposium has been kindly sponsored by @thermofishersci.bsky.social & @ccpem.bsky.social
nusbf.ncl.ac.uk
Grand Opening of the Northern eye, a cryo-TEM in Newcastle
Grand Opening of the Northern Eye in Newcastle, a100 kV Tundra cryo-TEM in Newcastle University on Wednesday 5th November 2025
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Jon Marles-Wright @jmarlesw.bsky.social · 29/09/2025
Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...
sciencedirect.com
Characterisation and engineering of thermostable PLP-dependent alpha-oxoamine synthases (AOSs); versatile C-C bond forming biocatalysts
The toolbox of C-C bond forming biocatalysts is forever expanding as demand increases for new and sustainable routes to organic molecules. One class o…
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system. 👉 @nclfungalgroup.bsky.social www.ncl.ac.uk/medical-scie...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports. Follow @proftracypalmer.bsky.social for more insights. www.ncl.ac.uk/medical-scie...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
Next up, @nickj-dent-res.bsky.social His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix. blogs.ncl.ac.uk/nickjakubovi...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
Next introducing Dr Alessandra Dantas. The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors. @alesdantas.bsky.social www.ncl.ac.uk/dental/about...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
Last introduction for the today.. Dr Kesha Josts @kjosts.bsky.social The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa. www.ncl.ac.uk/cbcb/staff/p...
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Microbes in Health and Disease @mhd-newcastle.bsky.social · 22/09/2025
@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running. www.marles-wright-lab.org
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Jon Marles-Wright @jmarlesw.bsky.social · 15/09/2025
Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.
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Kevin Waldron @waldronlab.bsky.social · 12/05/2025
Finally, we're recruiting! If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...
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Jon Marles-Wright @jmarlesw.bsky.social · 12/05/2025
York Uni campus looking splendid today. Visiting Biology for a viva.
A photograph of the lake at York University looking from Biology
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Jon Marles-Wright @jmarlesw.bsky.social · 25/04/2025
Happy April 25th to all who observe the perfect date.
media.tenor.com
a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it
ALT: a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it
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Jon Marles-Wright @jmarlesw.bsky.social · 08/04/2025
Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open: www.efbiotechnology.org/designerbiol...
Flier for the designer biology meeting.
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Jon Marles-Wright @jmarlesw.bsky.social · 14/02/2025
Congratulations!
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Kate Beckham @kshbeckham.bsky.social · 06/01/2025
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
findaphd.com
PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com
PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com
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Jon Marles-Wright @jmarlesw.bsky.social · 12/12/2024
Day trip to Sheffield for a very enjoyable encapsulin viva with @perbullough.bsky.social
A picture of the Christmas lights on the Sheffield children’s hospital viewed from Firth Court.
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Prof. Ruth Ley FRS @microbiome.bsky.social · 10/12/2024
Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...
biorxiv.org
Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5
The bacterial protein flagellin is the sole ligand of the innate immune receptor Toll-like receptor 5 (TLR5). Flagellins with strong agonism bind TLR5 at their D1 and D0 domains, while poor agonist si...
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Jon Marles-Wright @jmarlesw.bsky.social · 03/12/2024
He was saying how much he is enjoying working with you. Just need to get those pesky MTA’s sorted!
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Jon Marles-Wright @jmarlesw.bsky.social · 03/12/2024
A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.
A graduation photograph. Smiling graduated and me pictured with purple lighting.
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