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Jianxun Ren

@jianxunren.bsky.social
151 followers 161 following 27 posts

PI @ Changping Lab. Personalized functional mapping, Personalized neuromodulation, Neuroimage processing techs Find me: scholar.google.com/citations?user=i… www.pbfslab.com/team

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Reposted by Jianxun Ren
Jiayi Zhu @jiayizhu.bsky.social · 05/08/2026
Congratulations to my teacher Jianxun Ren, runner-up of the Science & PINS Neuromodulation Prize with his new Science article! 🏆 His research pioneers shifting brain stimulation from deep nuclei to the brain surface for Parkinson’s treatment. 🎉
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Wei Zhang @weizhangvvv.bsky.social · 05/08/2026
Huge congratulations! 🎉 This is a remarkable and visionary contribution to the field of neuromodulation. It is a great honor and privilege to have been part of this exciting journey.
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Jianxun Ren @jianxunren.bsky.social · 05/08/2026
Honored to be named the runner-up for the Science & PINS Prize for Neuromodulation, with my essay now published by @science.org science.org/doi/10.1126/... The essay lays out how mapping the brain's functional circuits lets us move neuromodulation from deep toward the brain surface.
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Jianxun Ren @jianxunren.bsky.social · 05/08/2026
Honored to be named the runner-up for the Science & PINS Prize for Neuromodulation, with my essay now published by @science.org science.org/doi/10.1126/... The essay lays out how mapping the brain's functional circuits lets us move neuromodulation from deep toward the brain surface.
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Mary Elizabeth Sutherland @meharpist.bsky.social · 19/06/2026
How does the brain build sentences? A recent @nature.com paper combined wide-scale recordings of single neurons with natural language processing models and found that there are specific neurons that only care if a word is a noun, or if a phrase is ending 🧪 www.nature.com/articles/s41...
nature.com
Mapping the neuronal building blocks of human language with language models - Nature
Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the...
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Dr. Nico Dosenbach & co. @dosenbachlab.bsky.social · 19/06/2026
$$$ is more strongly associated with the brain than IQ: science.org/doi/10.1126/... @smarek0502 @smerconish
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Nico Dosenbach @ndosenbach.bsky.social · 16/06/2026
Someone asked for stats comparing the two panels, which made me realize they hadn't paid attention to the axis labels. So I replotted the data with a tweaked logic. If the model predicts the variable it was trained on better left upper triangle, if it predicts the other better right lower. 💥💥💥 Boom!
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Nico Dosenbach @ndosenbach.bsky.social · 14/06/2026
We've known that socioeconomics (SES) matters for the 🧠. New & 🤯 is that SES drowns out all other brain associations, incl. IQ. If you train an algorithm to predict IQ from brain data, it's still way better at predicting SES. Science Mag: www.science.org/doi/10.1126/... @smarek0502.bsky.social 👀🧵👇
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Thomas Yeo @bttyeo.bsky.social · 13/06/2026
Openly shared implementation of TMS targeting is still rare, so we are pleased to make ours freely available for research use: github.com/ThomasYeoLab... Let us know if you have any issue running it!
github.com
GitHub - ThomasYeoLab/Kong2026_TMSTree: Tree-based MS-HBM TMS targeting algorithm
Tree-based MS-HBM TMS targeting algorithm. Contribute to ThomasYeoLab/Kong2026_TMSTree development by creating an account on GitHub.
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Michael Okun @michaelokun.bsky.social · 13/06/2026
Childhood brain development may be shaped more by neighborhood opportunity than IQ. Marek, Dosenbach and colleagues describe in a new paper in Science how socioeconomic factors may be the strongest predictors of brain organization in childhood, even exceeding measures such as IQ and psychopathology.
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Scott Marek @smarek0502.bsky.social · 12/06/2026
Thanks @ariellekeller.bsky.social ! And yes, please check out the amazing perspective by @lucindasisk.bsky.social and @ted-satterthwaite.bsky.social!
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Claire Cameron @clairehcameron.bsky.social · 11/06/2026
Is zip code everything? A new study involving U.S. children found it influences brain function and structure—specifically, kids in lower socioeconomic opportunity areas had sleep deprived and stressed brains. New on @sciam.bsky.social www.scientificamerican.com/article/chil...
scientificamerican.com
Children's zip codes change their brains
Children living in areas with low socioeconomic opportunities have more tired and stressed brains, a new study finds
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The Transmitter @thetransmitter.bsky.social · 11/06/2026
Brain scans can predict a child's socioeconomic status better than they can predict the child’s IQ. #neuroskyence By @natmesanash.bsky.social www.thetransmitter.org/brain-imagin...
thetransmitter.org
IQ’s link to brain structure, function in children may be a mirage
A child’s socioeconomic status, screen time and amount of sleep all show stronger associations with measures of brain structure and function, according to an imaging study of nearly 12,000…
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Science Magazine @science.org · 11/06/2026
A new Science study suggests variables linked to socioeconomic status—increased stress and reduced sleep—have strong relationships to brain structure and function in children. Brain differences observed are unrelated to genetic ancestry and may not be permanent. scim.ag/4opL5PF
Brain-wide associations in the Adolescent Brain Cognitive Development (ABCD) Study revealed that socioeconomic status exhibited the strongest associations with brain organization. Socioeconomic status dominated population-level variation through arousal-related patterns linked to sleep and stress, specifically norepinephrine and stimulant effect maps. Socioeconomic status models demonstrated robust generalizability across different groups, highlighting its importance as the primary variable in childhood BWAS. [Figure created by Lucy Reading-Ikkanda]
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Deanna Greene @deannajgreene.bsky.social · 12/06/2026
Remarkable stability in functional brain networks over time!
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NPR @npr.org · 11/06/2026
A study of more than 2,300 9- to 10-year-olds found that socioeconomic factors explained most differences in the preteens' brain development. n.pr/4xoA70O
n.pr
Socioeconomic factors are becoming 'biologically embedded' in children's brains
A study of more than 2,300 9- to 10-year-olds found that socioeconomic factors explained most differences in the preteens' brain development.
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Scott Marek @smarek0502.bsky.social · 11/06/2026
What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...
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Jianxun Ren @jianxunren.bsky.social · 28/05/2026
🧠 I'm so happy to share our personalized circuit-guided neuromodulation targeting platform UNITE, led by @weizhangvvv.bsky.social, is out in Nature Protocols @natureportfolio.nature.com ! 📄 Protocol: nature.com/articles/s41... 🔬 Nature: nature.com/articles/s41...
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Nature Protocols @natprot.nature.com · 28/05/2026
New Article! A generic, rapid and robust platform for personalized functional circuit-guided neuromodulation targeting
dlvr.it
A generic, rapid and robust platform for personalized functional circuit-guided neuromodulation targeting
Nature Protocols, Published online: 27 May 2026; doi:10.1038/s41596-026-01371-9This Protocol is for the identification of functional neural networks measured using resting state functional magnetic resonance imaging using an automated algorithm that can localize personalized targets for neuromodulation.
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Jianxun Ren @jianxunren.bsky.social · 28/05/2026
🧠 I'm so happy to share our personalized circuit-guided neuromodulation targeting platform UNITE, led by @weizhangvvv.bsky.social, is out in Nature Protocols @natureportfolio.nature.com ! 📄 Protocol: nature.com/articles/s41... 🔬 Nature: nature.com/articles/s41...
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Nico Dosenbach @ndosenbach.bsky.social · 26/05/2026
Shohei Ohtani is the Dave Holtzman of baseball. So it’s the greatest possible honor to be the inaugural David M. & Tracy S. Holtzman Professor of Neurology. Only Dave himself deserves that honor … but that would’ve been weird.
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WashU Medicine Neurology @washuneurology.bsky.social · 26/05/2026
Nico Dosenbach, MD, PhD, was installed as the inaugural David M. and Tracy S. Holtzman Professor of Neurology at WashU Medicine. He is widely recognized as a pioneer in precision neuroimaging. bit.ly/4tqBglq
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weigangcui.bsky.social @weigangcui.bsky.social · 22/05/2026
Lesion network mapping (LNM) links symptoms to brain circuits, but isolating symptom-specific effects remains challenging. We introduce robust LNM, a unified framework to reveal reliable, symptom-specific networks. biorxiv.org/content/10.64898/2026.05.18.725812v2
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Roselyne Chauvin @roselynechauvin.bsky.social · 23/04/2026
This is going to be my conversation starter at #ohbm2026 @ohbmofficial.bsky.social
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Nico Dosenbach @ndosenbach.bsky.social · 23/04/2026
Function & cytoarchitecture don't overlap ... they're orthogonal. Prefrontal cortex is plastered with chains of functional patches previously mostly known from face processing. Why multi-modal parcellations are wrong ... and other insights hidden by group-averaging of fMRI data. great explainer👇🏻
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Evan Gordon @gordonneuro.bsky.social · 22/04/2026
I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...
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Nature @nature.com · 16/03/2026
The brain–computer interface is the first in the world to be available for wider use outside of clinical trials go.nature.com/472hzbd
go.nature.com
China approves brain chip to treat paralysis — a world first
Chip allows people with paralysis to control a soft robotic hand.
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Jianxun Ren @jianxunren.bsky.social · 14/03/2026
Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social
Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper.
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Roselyne Chauvin @roselynechauvin.bsky.social · 13/03/2026
The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi. To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6... youtube.com/shorts/MryMq...
youtube.com
how does his brain do it ? #neuroscience #memory #sport Nelson Dellis 6x US memory champion
YouTube video by Roselyne Chauvin
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Nico Dosenbach @ndosenbach.bsky.social · 13/03/2026
Most of what's known about human memory stems from H.M., who had his hippocampus removed bilaterally. So we studied memory champion Nelson Dellis with precision brain mapping. Everyone's memory for numbers is crap ... 10 digits. He's memorized 10,000, by turning it into a skill, more like juggling
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Jianxun Ren @jianxunren.bsky.social · 14/03/2026
Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social
Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper.
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Waggoner Lab @labwaggoner.bsky.social · 26/02/2026
Parkinson’s disease as a somato-cognitive action network disorder @nature.com www.nature.com/articles/d41... www.nature.com/articles/s41...
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Jianxun Ren @jianxunren.bsky.social · 05/02/2026
It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social
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Jingnan Du @jingnandu.bsky.social · 12/02/2026
I am thrilled to share that I’ll be joining the University of Notre Dame (@notredame.bsky.social) as an Assistant Professor of Psychology this July!☘️🧠 Please reach out if you're interested in joining my lab! More details to follow soon.
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cjl2007.bsky.social @cjl2007.bsky.social · 12/02/2026
🚨 New preprint: Objective Quality Assessment for Precision fMRI Precision functional mapping (PFM) enables individual-level brain network studies — but demands more, and better, data. We introduce an objective framework to determine when a dataset truly supports interpretable, replicable PFM.
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Jianxun Ren @jianxunren.bsky.social · 05/02/2026
Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)
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Charlotte Reese Marshall @tomrhysmarshall.bsky.social · 05/02/2026
Really cool attempt to link together multiple neuromodulation methods (DBS, TMS, TUS) to understand the neural basis of Parkinson's disease.
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Nature @nature.com · 06/02/2026
Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide go.nature.com/4r0xZsk
go.nature.com
Immune cells from the gut drive development of Parkinson’s disease in the brain
In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.
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Jon Douglas @atranscendedman.bsky.social · 06/02/2026
Washington University researchers scanned 863 patients and found that Parkinson’s is not just a motor disorder. It stems from hyperactivity in the brain’s somato-cognitive action network, and treatments work best when they calm this network. www.nature.com/articles/s41...
nature.com
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
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Nasia Metoki @nasiametoki.bsky.social · 06/02/2026
Fantastic work showint how SCAN is related to Parkinson’s disease. Much promise for the future of battling the disease! www.nature.com/articles/s41...
nature.com
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
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Roselyne Chauvin @roselynechauvin.bsky.social · 06/02/2026
Such a fascinating paper! Less than 3 years after the discovery of the new motor network (SCAN) interleaved between effector motor regions, SCAN is proving highly relevant for Parkinson’s! It offers potential to improve treatment and reduce symptoms non-invasively.
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Skatingfool @michaelbruceschaub.bsky.social · 06/02/2026
Good news for Parkinson's sufferers. These researchers should review recent papers on Essential Tremor. ET researchers have identified the back of the brain as the ET problem area, the same area identified as part of the Parkinson's problem. Potential for beneficial cooperation. (I have ET.)
nature.com
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
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Mary Elizabeth Sutherland @meharpist.bsky.social · 30/01/2026
Happy Friday! For those of you who didn't see the excellent @nature.com paper showing that scientists who use AI tools produce more research but on a narrower range of topics, consider listening to the podcast: www.nature.com/articles/d41...
nature.com
AI can turbocharge scientists’ careers — but limit their scope
Hear the biggest stories from the world of science | 14 January 2026
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Donna Dierker @donnadierker.bsky.social · 06/02/2026
This is a nice animation illustrating the key points in the Parkinson's SCAN paper about which I posted previously.
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Max Korbmacher @maxkorbmacher.bsky.social · 09/02/2026
Ren, J., Zhang, W., Dahmani, L. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature (2026). doi.org/10.1038/s415...
doi.org
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
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WashU Medicine Neurology @washuneurology.bsky.social · 09/02/2026
A social club — started by Nico Dosenbach, MD, PhD and a colleague — dubbed the "Midnight Scan Club," leveraged low-cost nighttime fMRI scans to provide unique insights into individual brain function. Read all about the history of precision self-scanning: bit.ly/4qeuLjR
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The Science of Parkinson's @scienceofpd.bsky.social · 05/02/2026
Researchers propose that the somato-cognitive action network (SCAN) "hyperconnectivity is central to PD pathophysiology & its alleviation is a hallmark of successful neuromodulation"; #Parkinsons as a somato-cognitive action network disorder www.nature.com/articles/s41...
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Nasia Metoki @nasiametoki.bsky.social · 10/02/2026
Don’t miss out reading about this amazing work linking the SCAN to Parkinson’s disease. What are the best ways we could use this new knowledge?!
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NPR @npr.org · 10/02/2026
Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory. n.pr/4kpKWtv
n.pr
This complex brain network may explain many of Parkinson's stranger symptoms
Parkinson's disease appears to disrupt a brain network involved in everything from movement to memory.
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Jianxun Ren @jianxunren.bsky.social · 10/02/2026
In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date. See threads (1/4) 👇 nature.com/articles/s41...
nature.com
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
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