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Reposted by Jiayi Zhu

Jianxun Ren @jianxunren.bsky.social · 05/08/2026

Honored to be named the runner-up for the Science & PINS Prize for Neuromodulation, with my essay now published by @science.org science.org/doi/10.1126/... The essay lays out how mapping the brain's functional circuits lets us move neuromodulation from deep toward the brain surface.

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Jiayi Zhu @jiayizhu.bsky.social · 05/08/2026

Congratulations to my teacher Jianxun Ren, runner-up of the Science & PINS Neuromodulation Prize with his new Science article! 🏆 His research pioneers shifting brain stimulation from deep nuclei to the brain surface for Parkinson’s treatment. 🎉

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Jianxun Ren @jianxunren.bsky.social · 14/03/2026

Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social

Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper.

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Lead-DBS @lead-dbs.org · 06/03/2026

Please support Lead-DBS by buying our Lego Kit. Its also fun!

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Michael Fox @foxmdphd.bsky.social · 26/02/2026

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

biorxiv.org

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Andreas Horn @andreashorn.org · 27/02/2026

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

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Nature Portfolio @natureportfolio.nature.com · 10/02/2026

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

This is figure 5, which shows TMS targeting the SCAN versus effector-specific motor regions.

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Benjamin Kay @benjaminkay.bsky.social · 10/02/2026

More excellent reporting by NPR's Jon Hamilton about a new brain network that explains symptoms of Parkinson's that have befuddled brain researchers for decades. Kudos to @jianxunren.bsky.social and Hesheng Liu for this groundbreaking research in the journal Nature! doi.org/10.1038/s415...

doi.org

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Jianxun Ren @jianxunren.bsky.social · 10/02/2026

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date. See threads (1/4) 👇 nature.com/articles/s41...

nature.com

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Skatingfool @michaelbruceschaub.bsky.social · 06/02/2026

Good news for Parkinson's sufferers. These researchers should review recent papers on Essential Tremor. ET researchers have identified the back of the brain as the ET problem area, the same area identified as part of the Parkinson's problem. Potential for beneficial cooperation. (I have ET.)

nature.com

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Francesca Cesari @francesari.bsky.social · 07/02/2026

Targeting the somato-cognitive action network (SCAN) rather than motor regions doubles efficacy of TMS treatments for Parkinson’s disease. Seems that various DBS targets for Parkinson’s are selectively connected to the SCAN rather than effector-specific motor regions.🧪 www.nature.com/articles/s41...

nature.com

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Mary Elizabeth Sutherland @meharpist.bsky.social · 07/02/2026

The highlight of my week was the publication of "Parkinson’s disease as a somato-cognitive action network disorder" in @nature.com. It's a great paper that shows how conceptual changes in fundamental neuroscience - the discovery of SCAN - can improve treatment 🧪 www.nature.com/articles/s41...

nature.com

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Nico Dosenbach @ndosenbach.bsky.social · 08/02/2026

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

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Jiayi Zhu @jiayizhu.bsky.social · 06/02/2026

Game-changer for PD therapy! Our @Nature study shows targeting the SCAN network with non-invasive brain stimulation doubles efficacy—no surgery needed. #Therapy #BrainScience #HealthTech nature.com/articles/s41...

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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026

Check out our new work on the relationship between glioma and system-level functional networks! We identify that nearly all gliomas localize within a common brain functional network, Action-Mode Network (AMN) . biorxiv.org/content/10.64898/2026.01.05.697608v1

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Evan Gordon @gordonneuro.bsky.social · 05/02/2026

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

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Jianxun Ren @jianxunren.bsky.social · 05/02/2026

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

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Jianxun Ren @jianxunren.bsky.social · 05/02/2026

Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)

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Springer Nature @springernature.com · 04/02/2026

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

spklr.io

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

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Jianxun Ren @jianxunren.bsky.social · 06/01/2026

Very interesting findings! Gliomas selectively locate within in the Action-mode Network, using glioma network mapping derived from lesion network mapping @foxmdphd.bsky.social

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Nico Dosenbach @ndosenbach.bsky.social · 11/01/2026

Why are gliomas overwhelmingly found in the action-mode network (AMN)? Could its function be contributing or is it that its function lines up with gene expression & receptor patterns? Either way, it raises the possibility of using inhibitory neuromod of the AMN to treat gliomas. #cancerneuroscience

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Jianxun Ren @jianxunren.bsky.social · 05/02/2026

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social

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Nature Portfolio @natureportfolio.nature.com · 04/02/2026

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