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Jamie Hackett

@jamiehackett.bsky.social
2.5K followers 604 following 60 posts

Developmental (epi)genomics group at EMBL Rome Non-genetic inheritance. Epigenetic editing. ERC investigator 🇮🇹🇬🇧🇮🇪

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Jamie Hackett @jamiehackett.bsky.social · 13/01/2026
A fabulous project led by Alessandro Barenghi & @embl.org Rome facilities (GEVF) @neilhumph.bsky.social+ Jim Sawitzke 👏👏 together with our lab.
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Jamie Hackett @jamiehackett.bsky.social · 13/01/2026
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀 Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA) www.biorxiv.org/content/10.6...
biorxiv.org
Iterative engineering of a compact Cas9 ortholog for in vivo gene editing via single AAV delivery
The development of compact and efficient CRISPR-Cas systems is crucial for biomedical and therapeutic genome editing, particularly in vivo applications based on viral delivery. Here, we performed a co...
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Jamie Hackett @jamiehackett.bsky.social · 05/01/2026
This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...
biorxiv.org
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
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Jamie Hackett @jamiehackett.bsky.social · 04/10/2025
Important to raise this. Agree with Ewan, we essentially mean (a) But (a) *may* actually also involve aspects of (b) and (c), whilst there is absolutely an influence of (d) as a context. In this scenario of incomplete understanding I actually think ‘epigenetic’ is a useful terminology.
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EMBL @embl.org · 30/09/2025
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development. These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention. www.embl.org/news/science...
Fathers shape embryonic development through molecular ‘signatures’. Credits: Daniela Velasco/EMBL
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David Suter @davidsuter.bsky.social · 26/09/2025
📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways www.biorxiv.org/content/10.1...
biorxiv.org
Endogenous variability in transcription factor concentrations shapes their genome-wide occupancy
The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...
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Jamie Hackett @jamiehackett.bsky.social · 27/09/2025
Huge shoutout fantastic co-first leads @mdura.bsky.social @bbbranjan.bsky.social and all authors. Great collaboration with the fabulous Ana Boskovic Project enabled by @embl.org Human Ecosystems transversal theme! 🙏
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Jamie Hackett @jamiehackett.bsky.social · 27/09/2025
❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....
embopress.org
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...
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Jan Żylicz @jzylicz.bsky.social · 18/09/2025
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
biorxiv.org
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
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Jamie Hackett @jamiehackett.bsky.social · 21/05/2025
🤩🤩 it’s been a while
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Jamie Hackett @jamiehackett.bsky.social · 20/05/2025
New haircut 😁
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Jamie Hackett @jamiehackett.bsky.social · 19/05/2025
Awhh, my lab are absolute legends!
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Jamie Hackett @jamiehackett.bsky.social · 15/05/2025
... and it comes with a stipend!
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Jamie Hackett @jamiehackett.bsky.social · 15/05/2025
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training. The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social. #job #internship; see info below...
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Wolfgang Huber @wkhuber.bsky.social · 19/03/2025
Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome? Funding call with deadline 15 June, decisions in July. www.embl.org/about/info/s...
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Jamie Hackett @jamiehackett.bsky.social · 12/02/2025
This is great work Jake! the specificity of H3K4 editing in plants is very cool
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Jamie Hackett @jamiehackett.bsky.social · 12/02/2025
Personally, I am partial to a microbe or two. But yes, focus would be on mammalian physiology
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Jamie Hackett @jamiehackett.bsky.social · 11/02/2025
Absolutely
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Jamie Hackett @jamiehackett.bsky.social · 11/02/2025
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
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Jamie Hackett @jamiehackett.bsky.social · 30/12/2024
Last day to apply for a postdoc in systems epigenomics in sunny Rome! www.embl.org/jobs/positio...
embl.org
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
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Bork Group at EMBL Heidelberg @borklab.bsky.social · 19/12/2024
As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring www.nature.com/artic...
nature.com
Paternal microbiome perturbations impact offspring fitness
Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.
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Maxim Greenberg @maxvcg.bsky.social · 09/12/2024
Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins
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Rob Schneider @robertife.bsky.social · 08/12/2024
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now www.grc.org/histone-and-...
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Ewan Birney @ewanbirney.bsky.social · 06/12/2024
Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:
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Marzia Munafò @munafomarzia.bsky.social · 07/12/2024
One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥
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Jamie Hackett @jamiehackett.bsky.social · 03/12/2024
Hi Kitty, just pointing out this independent position. Lots of other opportunities coming up at EMBL in Rome too. www.embl.org/jobs/positio...
embl.org
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
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Duncan Sproul @sproullab.bsky.social · 03/12/2024
Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city: institute-genetics-cancer.ed.ac.uk/igc-graduate... Please share 🙏 (1/2)
institute-genetics-cancer.ed.ac.uk
MRC four-year International PhD programme: Human Genetics, Genomics and Disease
Applications now open.
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Jamie Hackett @jamiehackett.bsky.social · 03/12/2024
What a 1-2 last few days! Huge congrats Christa 👏
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Fyodor Urnov @urnov.bsky.social · 02/12/2024
The good news: you only click on the "join" button once and then you following all the pack persists in the absence of the initiating stimulus. 😀 In all seriousness, a stellar group of folks to follow.
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Peter Sarkies @psarkies.bsky.social · 02/12/2024
Protein-based inheritance could be the new frontier in understanding transgenerational epigenetic inheritance. Great preview from @odedrechavi.bsky.social and @ethanewe.bsky.social on a very interesting new paper from @wbderry.bsky.social lab.
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Jamie Hackett @jamiehackett.bsky.social · 02/12/2024
We are beginning to understand how the full repertoire of inheritable units can affect phenotypic variability Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…
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Christa Buecker @chribue.bsky.social · 02/12/2024
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
doi.org
Redirecting
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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 02/12/2024
Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025 Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts) www.grc.org/developmenta...
grc.org
2025 Developmental Biology Conference GRC
The 2025 Gordon Research Conference on Developmental Biology will be held in Pomona, California. Apply today to reserve your spot.
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Yaser Atlasi @yatlasi.bsky.social · 01/12/2024
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
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Jamie Hackett @jamiehackett.bsky.social · 02/12/2024
Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS
Advert detailing a postdoctoral scientist position at EMBL Rome. Contact: jamie.hackett@embl.it
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Jamie Hackett @jamiehackett.bsky.social · 29/11/2024
Many other super lab members not (yet) on Bluesky! So finally, two postdocs that just moved on... @denbobalab.bsky.social has established his group at MPI on #microbiome-germline axis. @mdura.bsky.social has just preprinted on #intergenerational-inheritance and is on the market! Check them out!
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Maxim Greenberg @maxvcg.bsky.social · 28/11/2024
Looks like a really interesting preprint from James Turner’s lab (who needs to migrate over here!) www.biorxiv.org/content/10.1...
biorxiv.org
Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo
Sex chromosomes are emerging as key regulators of adult health and disease in males (XY) and females (XX), but their impact on embryo development is poorly understood. Using single-cell RNA sequencing...
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
Don’t miss @steliostsagkris.bsky.social for infinite technical knowledge of CRISPR perturbation screening! Stelios is also the lab gastruloid guru 🧫 Always has interesting and constructive takes on papers so keep an eye on this one!
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
Fearless grad student @catrinteleri.bsky.social leads a major computational analysis project. Want to discuss polycomb function, ask Catrin! More of a silent scroller than prolific poster, if we all follow Catrin - apart from being quite funny - we’ll hear more of her insights!
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
We are blessed to have @bbbranjan.bsky.social. Follow Bobby for hot takes on preprints, microbiome and ML. Original computational biologist now wetlab guru! He also just co-first published a cracking preprint Oh, and he’s looking for ML/AI positions later next year👌
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Deborah Bourc’his @deborahbourchis.bsky.social · 28/11/2024
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
Next up, newest lab postdoc @gemnov.bsky.social. If you want the latest takes on quantitative biology, modelling or degrons this is your account! Also Gemma developed CasTuner with Edda Schulz - an amazing work
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇
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Jamie Hackett @jamiehackett.bsky.social · 28/11/2024
This is heroic educating!
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Jamie Hackett @jamiehackett.bsky.social · 27/11/2024
Placental-specific deletion of Slc25a1 - but not cardiac deletion - leads to heart defects. As Miguel indicates… placenta is the source of much unappreciated phenotypic variation and dev functions
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Jamie Hackett @jamiehackett.bsky.social · 27/11/2024
Absolutely! Dynamics are fundamental. As is often the case tho we need many ways of viewing/capturing the same process to understand it.
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Jamie Hackett @jamiehackett.bsky.social · 27/11/2024
CV is our favourite focus going forward!
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Jamie Hackett @jamiehackett.bsky.social · 27/11/2024
Thanks Serge!
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Jamie Hackett @jamiehackett.bsky.social · 27/11/2024
Yup we previously found placental defects induced by dysbiotic fathers. Here much earlier in dev we do find TE changes… BUT the PrE/EPI balance effect is more striking. What this means for placenta is open question. Appropriate PrE is important for implantation but also trophectoderm for example
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Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 27/11/2024
Our lab members are off to cool new jobs (including faculty 🎉) so we are looking for new team members. Experimental postdoc prioritized, but do get in touch if you think you are a good fit. Also, our PhD program is currently accepting applications: www.molgen.mpg.de/IMPRS/applic...
molgen.mpg.de
Application
The graduate program IMPRS for Biology And Computation (IMPRS-BAC) provides an education for students at the interface of molecular life sciences and computational sciences. This is based on perspective and supervision from both ends - experimental and computational - and suits students with degrees in molecular biology, biochemistry, mathematics, bioinformatics or any related areas. If you have a passion for epigenetics, bioinformatics, developmental biology, mathematics, sequence analysis, gene regulation, RNA biology, mechanobiology, protein biochemistry, stem cells and differentiation, statistics, molecular evolution or biophysics and want to work at the Max Planck Institute for Molecular Genetics or the Freie Universität Berlin - this is the program for you!
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