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Jose A Escudero

@jaescudero.bsky.social
1.2K followers 486 following 119 posts

Scientist interested in #integrons, antimicrobial resistance and the molecular basis of adaptation. Working at at CNB-CSIC.

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Jose A Escudero @jaescudero.bsky.social · 30/09/2026
Great opportunity!
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Craig MacLean @craigmaclean.bsky.social · 30/09/2026
Postdoc position available in my group to work on ERC funded project on evolutionary biology of antibiotic resistance. Looking for someone with expertise in bacterial genetics, AMR, and evolutionary biology. www.jobs.ac.uk/job/DSZ416/p...
jobs.ac.uk
Postdoctoral Research Associate at University of Oxford
Explore an exciting academic career as a Postdoctoral Research Associate. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
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Blake Ushijima, Ph.D. @vibriosoup.bsky.social · 17/09/2026
I'm always happy to see our collaborators from the van Kessel and Salomon labs at Vibrio 2028! Looking forward to more years of working on Vibrio coralliilyticus!
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Filipa Trigo da Roza @filipatr.bsky.social · 03/09/2026
It’s out! 🥹🎉 We’re so incredibly happy and proud to see this work out in the world. And once again, a huge thank you to the great mastermind @jaescudero.bsky.social and all the co-authors; this wouldn’t have been possible without you! doi.org/10.1038/s415... @natmicrobiol.nature.com
doi.org
High-throughput recovery of integron cassettes for gene discovery screens - Nature Microbiology
Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.
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Jose A Escudero @jaescudero.bsky.social · 03/09/2026
Thanks Dor! Hope to see you in a couple of weeks!
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Melanie Blokesch @mblokesch.bsky.social · 03/09/2026
Big congrats to Filipa @filipatr.bsky.social & @jaescudero.bsky.social & all co-authors 🎉🎊!! Beautiful study, which was nice to see evolving over time. Was a privilege to contribute natural competence/Vibrio expertise while hosting Filipa during her @embo.org short-term fellowship in my lab 🤩.
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 03/09/2026
🤔¿Cómo explorar la función de genes bacterianos que desconocemos? Un estudio liderado por el CNB @csic.es y la @ucm.es describe 2 herramientas que permiten generar bibliotecas de miles de estos genes para buscar funciones de interés DOI: f.mtr.cool/79e8krehgr ℹ️ f.mtr.cool/fw0jw34nzx
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Jose A Escudero @jaescudero.bsky.social · 03/09/2026
You are very modest (no pun intended)! You were a very important part of it, Modesto! Hopefully one of many collaborations!
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Jose A Escudero @jaescudero.bsky.social · 03/09/2026
Filipa, you did an amazing job in the delivery. We went through a lot together to make it work, indeed. But you did great! And our collaborators took it to the next level. Thanks to @mblokesch.bsky.social @mredrejo.bsky.social and @lopezigual.bsky.social!! But Filipa, you are the star!🌟 Tiramisu!!!
static.klipy.com
Tiramisu Bread Dessert with Fork
ALT: Tiramisu Bread Dessert with Fork
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Jose A Escudero @jaescudero.bsky.social · 03/09/2026
Great experience publishing. Our editor was great and our reviewers super constructive. Thank you all!
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Nature Microbiology @natmicrobiol.nature.com · 03/09/2026
Out Now! High-throughput recovery of integron cassettes for gene discovery screens #MicroSky
go.nature.com
High-throughput recovery of integron cassettes for gene discovery screens
Nature Microbiology, Published online: 03 September 2026; doi:10.1038/s41564-026-02474-5Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.
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Jose A Escudero @jaescudero.bsky.social · 23/06/2026
Beautiful work, Carmen! Congratulations! Enjoy!
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Beuzón & Ruiz-Albert Lab @type3lab.bsky.social · 23/06/2026
Many thanks to the Molecular Microbiology group of the Spanish Society of Microbiology (SEM) for awarding us with one of the two Josep Casadesús Prizes for best paper! rdcu.be/egczU Congrats also to @jaescudero.bsky.social for his!
rdcu.be
Pseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection
Nature Microbiology - Single-cell gene expression analysis reveals phenotypic heterogeneity to enable bacterial specialization over the course of plant colonization.
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Jose A Escudero @jaescudero.bsky.social · 04/05/2026
Interesting, and sequencing-based. "These findings definitively point to the ancestral origin of the Columbus lineage within the noble houses of Northern Spain, specifically the Zúñiga (Navarre) and Sotomayor (Galicia) families" Do you reckon this will settle things? www.biorxiv.org/content/10.6...
biorxiv.org
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Michael Clemens @mclem.org · 27/04/2026
The United States now has the most government restrictions on academic freedom of any high-income country. www.chemistryworld.com/news/academi... Raw data from @vdeminstitute.bsky.social —> academic-freedom-index.net/research/Aca...
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Mizrahi Lab @mizrahilab.bsky.social · 26/04/2026
"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...
nature.com
Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology
Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.
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Sara Mitri @saramitri.bsky.social · 22/04/2026
Check out Snorre's latest preprint: www.biorxiv.org/content/10.6... I love this story: our 4-species synthetic bacterial community coexists across many simple environments and conditions. We show why (spoiler in the title)
biorxiv.org
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 13/04/2026
En #AGolpeDeBit #RTVE, @sanmillan.bsky.social investigador del #CNB @csic.es habla de este estudio liderado junto a Alfonso Santos López @uam.es y en colaboración con Ayari Fuentes #UNAM_MX centrado en el plásmido pOXA-48 de gran interés clínico 📻 ¡No te lo pierdas! www.rtve.es/play/audios/...
rtve.es
Resistencia a antibióticos: hallada nueva clave en plásmidos
Ponemos el foco en un estudio que identifica un nuevo mecanismo por el que los plásmidos pueden acelerar la aparición de resistencia a los antibióticos
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Jose A Escudero @jaescudero.bsky.social · 06/04/2026
Check out our latest work. Huge effort from @filipatr.bsky.social and the MBA team in collaboration with @mblokesch.bsky.social @mredrejo.bsky.social and @lopezigual.bsky.social Thanks to all!!
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Filipa Trigo da Roza @filipatr.bsky.social · 20/03/2026
New preprint alert!!! 🚀🤓 We are very happy to finally share this with the world — the result of seven years of work and a new tool to study integrons and discover new functions encoded in these bacterial platforms. If you want to know more, here is a thread 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Nature @nature.com · 02/04/2026
Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies. go.nature.com/4dqQnXI
go.nature.com
‘Treasure trove’ of antiviral proteins could inspire powerful molecular tools
Two research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.
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Jose A Escudero @jaescudero.bsky.social · 03/04/2026
Great work! Congrats!
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Jose A Escudero @jaescudero.bsky.social · 03/04/2026
Beautiful work! Bravo!!
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Aude Bernheim @audeber.bsky.social · 02/04/2026
How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
science.org
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Sorek Lab @soreklab.bsky.social · 02/04/2026
A big advance in the field of bacterial immunity, from the Bernheim and Laub labs
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 02/04/2026
Cool tool to capture genes using a hunter gatherer 🦠 Large-scale recovery of integron cassettes for gene discovery screens www.biorxiv.org/content/10.6... by @jaescudero.bsky.social @afpcarvalho.bsky.social @filipatr.bsky.social
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Jose A Escudero @jaescudero.bsky.social · 27/03/2026
Great work! Congrats, team!
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Teresa M. Coque @tmcoque.bsky.social · 26/03/2026
1. Despite limited Ab exposure, the Wayampi gut microbiome harbors a robust "background" resistome of ACQUIRED resistance genes (antibiotic, metal, biocide) shared with Westerns=AMR is an ancient and conserved feature rather than solely a by-product of human activities.
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Filipa Trigo da Roza @filipatr.bsky.social · 20/03/2026
1/11 First, I want to thank the mastermind behind this project @jaescudero.bsky.social , who dreamed and battled alongside me to get here. And it wasn't a walk in the park 😅
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Elisabeth Bik @elisabethbik.bsky.social · 13/03/2026
New blog post: The Camel's Camel. Today, I found a beautiful example of synonymized plagiarism involving the microbiome of a camel’s udder. #TorturedPhrases #ScienceIntegrity #ResearchIntegrity scienceintegritydigest.com/2026/03/12/t...
A cartoon drawing of a light brown camel with one hump. At the position where one might find an udder, we see a baby camel hanging. It is to illustrate the absurdity of the sentence "The definition and definition of microbes on the camel’s camel is very important ", found in the abstract of a paper about the camel udder microbiome.
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Jose A Escudero @jaescudero.bsky.social · 11/03/2026
I am not very active lately in social media, but if you want to see one of our latest works check Alberto’s post on the fitness cost of AMR genes. Great delivery from him and all collaborators. Thanks, guys! bsky.app/profile/albe...
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Alberto HCA @albertohca.bsky.social · 10/03/2026
Great work led by MBAlab @jaescudero.bsky.social with the invaluable collaboration of @sanmillan.bsky.social @baerboletta.bsky.social @penamiller.bsky.social and @ayari.bsky.social
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Alberto HCA @albertohca.bsky.social · 10/03/2026
Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 20/11/2025
👏 Dos proyectos del #CNB seleccionados en la convocatoria de Investigación en Salud 2025 de la @caixaresearch.bsky.social Ambos abordan un gran reto global: la resistencia a los antimicrobianos. #HealthResearch #FundaciónlaCaixa @sanmillan.bsky.social @jaescudero.bsky.social f.mtr.cool/jejatlbssz
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Jose A Escudero @jaescudero.bsky.social · 05/11/2025
Can I be included? Pleaaaaaaseeeeee!
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Pablo Laborda @pablolaborda.bsky.social · 25/10/2025
New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 06/09/2025
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
science.org
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
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Melanie Blokesch @mblokesch.bsky.social · 06/09/2025
Excited to share my latest review, now published in the Royal Society theme issue on ‘The ecology and evolution of bacterial immune systems' (available OA): Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org
Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae | Philosophical Transactions of the Royal Society B: Biological Sciences
Vibrio cholerae, the causative agent of cholera, has triggered seven pandemics, with the seventh pandemic emerging in 1961. The success of seventh pandemic El Tor (7PET) V. cholerae as a human pathogen is linked to its acquisition of mobile genetic ...
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Jose A Escudero @jaescudero.bsky.social · 30/08/2025
A pleasure to read, as all Andreas Wagner’s books. They always shake some of the pillars that support my view of things. I highly recommend reading all of them, especially to young scientists. In Sleeping beauties I particularly enjoyed the mix with neuropsychology.
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 26/08/2025
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis. f.mtr.cool/rnstpoiucs
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 18/08/2025
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis. f.mtr.cool/czgfpzevqu
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 05/08/2025
Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects? 🦠 =>processes evolutionarily tuned to be sensitive to translation speed eg: motility, iron homeostasis, leader peptide attenuation (ex: trp). #rnasky #microsky www.sciencedirect.com/science/arti...
sciencedirect.com
Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects?
By integrating a literature review with transcriptomic, proteomic, and phenotypic data from two model bacteria, Escherichia coli and Vibrio cholerae, …
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Alvaro San Millan @sanmillan.bsky.social · 04/08/2025
Oxygen levels can affect how resistance genes work, impacting antibiotic efficacy. This can be relevant for the most used ones: for example, resistance to fosfomycin varies with oxygen. Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social #AntibioticResistance
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 24/07/2025
A 2 yr postdoc position at the Bacterial Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
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Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · 25/07/2025
🚨🚨 New paper in @narjournal.bsky.social! 🍾 Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons). We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín. 👇
academic.oup.com
ExcludonFinder: mapping transcriptional overlaps between neighboring genes
Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc
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Jose A Escudero @jaescudero.bsky.social · 23/07/2025
Congrats Carlos!! Very nice!!!
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Alexander Harms @aharms485.bsky.social · 22/07/2025
When the MSc student of Enea @phagemuffin.bsky.social is working in a brewery... 🍺🧬
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Oded Rechavi @odedrechavi.bsky.social · 22/07/2025
A gym that you go to but instead of working out you write papers
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Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · 22/07/2025
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
biorxiv.org
Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate
Plasmids are autonomously replicating DNA molecules that stably coexist with chromosomes in bacterial cells. These genetic elements drive horizontal gene transfer and play a fundamental role in bacter...
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