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Mizrahi Lab

@mizrahilab.bsky.social
298 followers 244 following 140 posts

We are involved in understanding the ecological and evolutionary forces that shape microbial communities in nature. Visit our website - lifewp.bgu.ac.il/wp/imizrahi/

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Mizrahi Lab @mizrahilab.bsky.social · 06/09/2026
When we look at microbial communities, we realize just how crucial they are. The same goes for science! We’re excited to share our latest discovery about the essential parts of a microbial ecosystem if the Rumen at #ISM26.
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Thomas Clavel @tclavel.bsky.social · 26/08/2026
Drawing on the team’s knowledge acquired over the years, we share our thoughts here on how to enhance microbiome research with FAIR collections of microbial strains: 🔥 www.nature.com/articles/s41... @nfdi4microbiota.bsky.social, @spp2474.bsky.social, @dsmz.bsky.social, @natmicrobiol.nature.com.
nature.com
A roadmap to create FAIR collections of microbial strains - Nature Microbiology
Here the authors propose guidance on the process of establishing a state-of-the-art collection of microorganisms, including project planning, strain deposition and the naming of new taxa.
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Alvaro Sanchez @asanchezlab.bsky.social · 21/08/2026
New preprint from the lab: The Latent Simplicity of Microbial Ecological Interactions www.biorxiv.org/content/10.6... We're excited about this one. We find that high-order microbial interactions often obey simple linear laws making microbial communities far more predictable than one might expect
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Amiyaal Ilany @amiyaal.bsky.social · 23/08/2026
Looking for a postdoc fellowship to study sociality and the microbiome? Talk to me about applying to this excellent fellowship: azrielifoundation.org/fellows/inte...
azrielifoundation.org
International Postdoctoral Fellowship - The Azrieli Foundation
The Azrieli Fellows Program is an elite group of academics who cultivate a network of leading professionals in Israel and around the world.
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Manas Guria, PhD @mkguria24.bsky.social · 29/07/2026
How do bacteria communicate with neighboring cells?🦠🦠 Excited to share my postdoc work is out! Preprint: www.biorxiv.org/content/10.6... We captured a remarkable event of nanotube-mediated cel-cell communication in live bacterial cells and discovered a novel bacterial organelle: the "Tubeosome".
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Mizrahi Lab @mizrahilab.bsky.social · 23/08/2026
Great pleasure speaking at ISME this year on the ecological principles behind the rumen microbiome and its relationship with the host. Also a wonderful chance to visit Auckland! Thanks to the organizers, Nathan Atwood for the invite, and @katielawther.bsky.social for the photo 📸
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Mizrahi Lab @mizrahilab.bsky.social · 14/08/2026
We excited to share "Seeing the Unseen", our lab's half-year collaboration with artists Tamara Anna Efrat & Shaul Cohen and curator Maya Dvash, translating microbial ecology into art. Join The Grand Opening : 📍 Trumpeldor Gallery, Beer Sheva 📅 29.10.26 🔗 lifewp.bgu.ac.il/wp/stu/?page_id=22
lifewp.bgu.ac.il
Register Here – Seeing The Unseen
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Alvaro Sanchez @asanchezlab.bsky.social · 01/07/2026
New preprint from our lab Statistical learning of bacterial growth in combinatorially constructed environments, led by brilliant PhD student Andrea Arrabal. www.biorxiv.org/content/10.6... We systematically study nutrient-nutrient interactions in bacterial growth under carbon-limiting conditions.
biorxiv.org
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Mizrahi Lab @mizrahilab.bsky.social · 30/07/2026
Designing microbial communities is hard, and making them perform specific functions is even harder. @oventurelli2.bsky.social lab show that ML + Bayesian optimization can identify the right fiber–microbe combinations. A proof of concept for rational microbiome-diet design. doi.org/10.1038/s415...
doi.org
Designing fiber–gut microbiome interactions with active learning - Nature Chemical Biology
Dietary fibers are a primary energy source for gut bacteria and shape the composition and function of the microbiome. Now, an active learning approach integrating explainable machine learning, Bayesia...
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Martina Dal Bello @martinadalbello.bsky.social · 17/07/2026
Excited that this is finally out, led by @jhuisman.bsky.social with Jeff Gore, combining experiments, theory and natural microbiome data! As salinity rises, diversity and individual species growth rates fall, yet community's overall growth stays robust: faster growers take over and keep it going.
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Mizrahi Lab @mizrahilab.bsky.social · 24/07/2026
Can giving a microbial community MORE food options make it LESS diverse? New study says yes. Classic theory: more resources = more niches = more species co-exist. But in half their communities, diversity dropped instead, some strains just eat more when given options! www.nature.com/articles/s41...
nature.com
Increased nutrient diversity can induce loss of microbial diversity through enhanced resource uptake - Nature Ecology & Evolution
Increasing nutrient diversity is expected to promote microbial diversity. This study shows that more complex environments can enhance resource uptake, intensify competition and lead to microbial biodi...
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Manuel Kleiner @manuelkleiner.bsky.social · 10/07/2026
The type and amount of bacterial DNA carried by virus-like particles in the gut microbiome is simply mind-boggling. Amazing work by PhD candidate Jessie Maier in my group and collaborators @duerkoplab.bsky.social and Ben Callahan www.biorxiv.org/content/10.6...
biorxiv.org
Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome
Horizontal gene transfer (HGT) is a driving force in microbial evolution that allows community members to rapidly evolve to cope with environmental stressors and competition. Despite the importance of...
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Mizrahi Lab @mizrahilab.bsky.social · 09/07/2026
Understanding how complex ecosystems assemble is hard. Predicting their behavior from individual components alone? Much harder. @dsegre.bsky.social show that monoculture metabolic profiles are enough to predict coexistence and design stable multi-species consortia. doi.org/10.64898/202...
doi.org
Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia
Synthetic microbial ecology aims at designing communities with desired properties based on mathematical models of individual organisms. It is unclear whether simplified models harbor enough detail to ...
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Mizrahi Lab @mizrahilab.bsky.social · 25/06/2026
How to give a bad talk? Short and precise points by @itaiyanai.bsky.social on how to give a talk and present your ideas. Highly recommend saving this and reading it before your next presentation. www.nature.com/articles/s41...
nature.com
How to give a bad talk - Nature Reviews Cancer
Effective presentations require clarity and audience awareness. In this Comment, Itai Yanai outlines common misconceptions about presentations and how to address them to deliver more impactful and ins...
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Reinier Egas @raegas.bsky.social · 14/04/2026
Grab a coffee and enjoy reading up on CO metabolism in methanotrophs! Freshwater ANME (own work): www.nature.com/articles/s41... Marine ANME (@Orphan lab): www.nature.com/articles/s41... Big thanks to our collaborators at QUT! @sjmcilroy.bsky.social (Heyu/Andy/Gene!) @cuwelte.bsky.social
nature.com
Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea - Nature Communications
Anaerobic methane-oxidizing archaea mitigate methane emissions in anoxic environments. Here, Egas et al. show that these microbes can also oxidize carbon monoxide, prompting re-evaluation of their cla...
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Mizrahi Lab @mizrahilab.bsky.social · 18/06/2026
One mutation. 23 species. Total community reshuffle. A 4-yr synthetic bacterial community experiment shows a single species evolving antibiotic resistance was enough to flip the entire community's state. Great work all!! @teppo-h.bsky.social www.pnas.org/doi/10.1073/...
pnas.org
Evolution induced state shifts in a long-term microbial community experiment | PNAS
Biological communities are complex, dynamic systems that underpin ecosystem functionality, yet their long-term dynamics and predictability remain p...
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Segata Lab @cibiocm.bsky.social · 16/06/2026
🥁 NEW study @vheidrich.bsky.social et al. on oral and gut microbiome and #straintransmission is now published in @cellpressblue.bsky.social www.cell.com/cell-press-b... 👏 Kudos to all the authors and collaborators! [illustration by Betina Servaes] 1/n
Betina S. illustration
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Ran Blekhman @blekhman.bsky.social · 16/06/2026
Nine (not so simple) steps: a practical guide to using machine learning in microbial ecology Step 1: Determine whether machine learning is necessary or even worth doing journals.asm.org/doi/10.1128/...
journals.asm.org
Nine (not so simple) steps: a practical guide to using machine learning in microbial ecology | mBio
Microbial ecologists are increasingly turning to machine learning (ML) models to better identify and predict meaningful biological patterns and relationships in molecular microbial community data (inc...
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Pawel Burkhardt @pawelburkhardt.bsky.social · 16/06/2026
How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...
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Mizrahi Lab @mizrahilab.bsky.social · 09/06/2026
Fascinating new science in @pnas.org! Turns out "aerobic" soil bacteria have a survival trick. When oxygen drops, they adapt by hybridizing fermentation with carbon storage to stay alive! Nature's resilience is unmatched. @greening.bsky.social www.pnas.org/doi/abs/10.1...
pnas.org
Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage | PNAS
In soil ecosystems, aerobic bacteria survive oxygen deprivation (hypoxia) by entering nonreplicative persistent states. In contrast to the well-stu...
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BejaLabTechnion @bejalab.bsky.social · 02/06/2026
Physiological trade-offs drive the archaeal dominance and carbon turnover in deep subsurface www.biorxiv.org/content/10.6...
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Sara Mitri @saramitri.bsky.social · 22/05/2026
Check out our pre-print led by the fantastic Massimo Amicone, collaborating with the Bollenbach lab! tinyurl.com/4h9p8mfb We build a simple intuition on how ecological interactions affect resistance evolution by expanding evolutionary rescue theory and testing it with two large sets of experiments
tinyurl.com
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BejaLabTechnion @bejalab.bsky.social · 20/05/2026
we got the cover!!! Novel light-driven schizorhodopsins from Antarctic Minisyncoccota (Patescibacteria) and cyanobacteria www.sciencedirect.com/science/arti...
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Mizrahi Lab @mizrahilab.bsky.social · 20/05/2026
Building all combinations of microbial strains used to require tedious work or pricey robotics. A new, rapid, low-cost method makes full factorial assembly accessible to any lab. Great work - Great impact! @asanchezlab.bsky.social elifesciences.org/articles/101...
elifesciences.org
Full factorial construction of synthetic microbial communities
A rapid, inexpensive, and easy to implement experimental protocol enables the construction of combinatorially complete sets of microbial consortia.
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Mizrahi Lab @mizrahilab.bsky.social · 08/05/2026
We often use dimensional reduction to simplify data, but what if geography is the point? In our @cp-trendsmicrobiol.bsky.social paper, we explore 3D spatial organization, covering latest methods, findings, and the big questions this frontier opens up. (1/3) www.sciencedirect.com/science/arti...
sciencedirect.com
Micro-scale spatial metagenomics opens a new era in microbiome ecology
Understanding microbial communities requires moving beyond 2D representations toward a holistic view that couples 3D spatial organization with ecologi…
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Ákos T Kovács @evolvedbiofilm.bsky.social · 04/05/2026
Managing microbial interactions in environmental biotechnology: can we scale interaction principles? @cp-trendsmicrobiol.bsky.social Review by @wenyugu.bsky.social (EPFL), Xiang-Yi Li Richter, and Dave Johnson at @eawag.bsky.social www.cell.com/trends/micro...
cell.com
Managing microbial interactions in environmental biotechnology: can we scale interaction principles?
Microbial interactions hold vast potential for improving sustainability, including waste upcycling, greenhouse gas mitigation, contaminant bioremediation, and host performance. However, attempts to ma...
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Prof. Ruth Ley FRS @microbiome.bsky.social · 03/05/2026
Come and work with us in a beautiful corner of Germany: 5 years of funding for your microbiology research and lots of great colleagues 🦠🧫
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Nature Microbiology @natmicrobiol.nature.com · 24/04/2026
Out Now! Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires #MicroSky
go.nature.com
Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires
Nature Microbiology, Published online: 24 April 2026; doi:10.1038/s41564-026-02318-2Cayman enables computational analysis of carbohydrate-active enzymes (CAZymes) in microbial community data. It revealed novel mucus-foraging gut microorganisms and differences in gut microbial CAZyme repertoires associated with lifestyle and disease.
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Typas Lab @typaslab.bsky.social · 29/04/2026
Check our new preprint by Knopp M. et al.! Human gut microbiomes can impose strong +/- selection for resistant versions of resident opportunistic pathogens. In the case we follow up, selection is driven by altered carbohydrate utilisation that the resistant mutant evolves. doi.org/10.64898/202...
doi.org
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Seth Shipman @seth-shipman.bsky.social · 23/04/2026
Out now in Nature Biotechnology! Alejandro González-Delgado and a fantastic team of collaborators worked across nine labs to get retron recombineering up-and-running in fifteen bacterial species. Molecular parts on addgene: www.addgene.org/browse/artic... Happy editing!
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Mizrahi Lab @mizrahilab.bsky.social · 26/04/2026
"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...
nature.com
Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology
Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.
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Plasmid Society @plasmidsociety.bsky.social · 02/04/2026
Please remember that the International Symposium on Plasmid Biology (ISPB 2026) will take place 7–11 September 2026 in Berlin, Germany! A great opportunity to meet, reconnect, and engage with the global plasmid biology community. 🤝 plasmid-biology-2026.de
plasmid-biology-2026.de
International Symposium on Plasmid Biology 2026
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Mizrahi Lab @mizrahilab.bsky.social · 23/04/2026
New benchmark by @tclavel.bsky.social & @treichelnicole.bsky.social reveals that while 0.5 Gb works for profiling, de novo MAG assembly requires >10 Gb. Crucially, they found that only 55-82% of high-quality MAGs accurately represented original strains. Full Article: doi.org/10.1038/s415...
doi.org
Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis - Nature Microbiology
A comparison of sequencing of complex mock communities performed at multiple depths and analysed using different methods establishes minimum standards that can ensure the accuracy of metagenomic analy...
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Hall Lab @halllab.bsky.social · 22/04/2026
New paper out in Nature Comms 🎉 Congrats to first author @sekid.bsky.social & thanks team & collaborators We show that B. bifidum & E. coli can cooperate in the breastfed infant gut through nutrient cross-feeding, helping shape early-life microbiome development 🦠👶 www.nature.com/articles/s41...
nature.com
Human milk oligosaccharide mediates mutualism between Escherichia coli and Bifidobacterium bifidum - Nature Communications
Escherichia coli is widespread in healthy breastfed infants, yet its ecological role is unclear. Here, the authors provide insights into the mechanisms supporting its persistence and co-existence with...
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Sorek Lab @soreklab.bsky.social · 23/04/2026
We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...
biorxiv.org
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Tami Lieberman @contaminatedsci.bsky.social · 22/04/2026
Interested in a *staff computational scientist* position? We are looking for an experienced computational biologist (ideally with microbiology experience) to support published packages while also driving new research. Pay range $73k-$111k w excellent benefits. careers.peopleclick.com/careerscp/cl...
careers.peopleclick.com
Computational Biology Program Scientist
MIT - Computational Biology Program Scientist - Cambridge MA 02139
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Quanta Magazine @quantamagazine.org · 20/04/2026
A powerful electrical motor propels bacteria in virtually every gut and puddle on Earth. After 50 years, it has finally been understood. @nattyover.bsky.social reports: www.quantamagazine.org/what-physica...
quantamagazine.org
What Physical ‘Life Force’ Turns Biology’s Wheels? | Quanta Magazine
The bacterial flagellar motor is finally understood after 50 years. In its workings, columnist Natalie Wolchover finds the essence of life.
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Harry Low’s Lab @lowlab.bsky.social · 20/04/2026
Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens.. doi.org/10.1093/isme...
doi.org
An enhanced domestication method for uncultured bacteria
Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m
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Mizrahi Lab @mizrahilab.bsky.social · 20/04/2026
New Review in Animal Microbiome explores the "plastic" window of assembly as a potential intervention window for more sustainable ruminants. Great Overview by Limei Lin, Milka Popova, lIma Tapio, Le Luo Guan & Jana Seifert! link.springer.com/article/10.1...
link.springer.com
Harnessing the early-life gut microbiome for sustainable ruminant production - Animal Microbiome
Animal Microbiome - The gut microbiome is a dynamic and complex ecosystem that plays an important role in determining ruminant health, productivity, and environmental footprint. Its plasticity...
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Alex Gao @algao.bsky.social · 16/04/2026
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Christian Kost @kostchristian.bsky.social · 17/04/2026
New paper of the group with Andreas Messer as the leading author - a very talented master student that is now on the market for a PhD: Cognition without brains? Learning and memory in microorganisms @cp-trendsmicrobiol.bsky.social @ileonardo Check it out 👇 www.sciencedirect.com/science/arti...
sciencedirect.com
Cognition without brains? Learning and memory in microorganisms
Memory and learning are cognitive abilities typically associated with animals that possess a complex nervous system. Interestingly, recent studies sug…
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Mizrahi Lab @mizrahilab.bsky.social · 10/04/2026
Endemic within Endemic🦎 We are happy to share our latest publication in @isme-microbes.bsky.social! This time, we explored the Galápagos marine iguana with a simple question: If these iconic animals are endemic, are their microbes endemic too? The answer is yes! (1/8) doi.org/10.1093/isme...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 03/04/2026
Micro-scale spatial metagenomics opens a new era in microbiome ecology @cp-trendsmicrobiol.bsky.social Opinion from @mizrahilab.bsky.social www.cell.com/trends/micro...
cell.com
Micro-scale spatial metagenomics opens a new era in microbiome ecology
Understanding microbial communities requires moving beyond 2D representations toward a holistic view that couples 3D spatial organization with ecological function, integrating microbial inventories, g...
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Jack A Gilbert @gilbertjacka.bsky.social · 30/03/2026
New paper out today in @microbiomej.bsky.social: “Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study.” We show that a simple soil-on-rug intervention can shift bacterial microbiota in house dust in urban homes. link.springer.com/article/10.1...
link.springer.com
Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study - Microbiome
Background Urban lifestyles are characterized by reduced encounters of environmental microbe stimuli that activate immunoregulatory pathways. This has been linked to an increased risk of inflammatory ...
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Mizrahi Lab @mizrahilab.bsky.social · 30/03/2026
New study on honeybee gut microbiota! It shows how priority effects allow first-arriving strains to dominate their niche, creating unique microbial profiles even in identical environments. Cool Study! @aiswarya.bsky.social, @pengellab.bsky.social, @dmf-unil.bsky.social doi.org/10.1093/isme...
doi.org
Priority effects drive strain-level community composition of honeybee gut microbiota
Abstract. Gut microbial communities often differ at the strain level among individual hosts, but the mechanisms driving this variation remain poorly unders
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Mizrahi Lab @mizrahilab.bsky.social · 25/03/2026
Really enjoyed reading this thoughtful and well-crafted review on cellulosome engineering and lignocellulose degradation. Kudos to the authors for a clear and impactful synthesis of the field. A valuable contribution to biotechnology and sustainable energy. www.sciencedirect.com/science/arti...
sciencedirect.com
Constructing cellulosomes to enhance lignocellulose degradation and biotechnological applications: A review
The increasing demand for sustainable and renewable energy sources has intensified research efforts on the development of efficient lignocellulose bio…
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Mizrahi Lab @mizrahilab.bsky.social · 09/03/2026
Understanding our limitations is a great way to say that we are cautiously optimistic about the future of community design. Moreover, it opens the door to new tools for understanding interactions! Great work Alvaro and team!
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Alvaro Sanchez @asanchezlab.bsky.social · 09/03/2026
New preprint on the limits of detecting higher-order interactions in microbial communities. www.biorxiv.org/content/10.6... We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.
biorxiv.org
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Charles Mullon @charlesmullon.bsky.social · 09/03/2026
With @saramitri.bsky.social, @sonjalehtinen.bsky.social and L. Lehmann we’ve launched the UNIL Center for Theory in Ecology and Evolution @unil.bsky.social🇨🇭 To kick things off, we’re offering short visiting fellowships for theorists in ecology & evolution. Apply & pls RP 😀 tinyurl.com/2wem36zz
unil.ch
Unil center for theory in ecology and evolution (UCTEE) - FBM Unil
Page Unil Center for Theory in Ecology and Evolution of site Faculty of Biology and Medicine hosted by the University of Lausanne
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ASM @asm.org · 07/03/2026
125+ years of microbial science history, all in 1 place 🧫✨ Explore ASM’s new virtual exhibit featuring archives, stories and milestones that shaped our global community. Start exploring: asm.social/2Qk
ASM figures are pictured across images, representing timeline of ASM's history.
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