Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying mos...

Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids, combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells on neuronal activity and surv...

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...

Highlighted Article: A previously unreported non-genomic androgen signaling pathway in embryonic development is revealed by a chemical-genetic screen in zebrafish.

Salmonids have a resident bacterial community in the brain.