dlvr.it
Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions
The genes that encode our antibodies display extensive variation between individuals. Corcoran et al. developed a high-throughput sequence-based method for identifying variations in antibody genes (ImmuneDiscover). This enabled the sequencing of 2,486 individuals with 25 different population ancestries, identifying variations that are population specific and may underlie differences in disease susceptibility and vaccine response at both an individual and population level.