iiinova — where your digital self keeps evolving

Melanie McReynolds @drohsopretty.bsky.social · 16/04/2026

The gentle reminder I needed to continue to show up authentically in science! Grateful and overjoyed.

Reposted by Melanie McReynolds

Hypothesis Fund @hypothesisfund.bsky.social · 16/04/2026

📣 Bold science alert! We're thrilled to announce our latest awardees who are pushing the boundaries of research in aging, regeneration, and bacterial resilience. bit.ly/HFAwardees Hear from the #HFScouts who championed these talented scientists👇 in our 🧵: 1/

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Reposted by Melanie McReynolds

Hypothesis Fund @hypothesisfund.bsky.social · 16/04/2026

2/ Awardee @drohsopretty.bsky.social hypothesizes that aging is caused by a breakdown in metabolic communication 💬 between cells. Her work introduces a new conceptual layer to aging biology, and may be key to restoring metabolic aging. 🥳 Congrats Dr. McReynolds! 🙏 #HFScout @harmitmalik.bsky.social

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Melanie McReynolds @drohsopretty.bsky.social · 16/02/2026

Excited to share our lab’s latest contribution where we highlight a new development for a bifunctional enzyme that mitigates redox imbalance and lipotoxicity for the potential use as a treatment for metabolic disorders. www.nature.com/articles/s42...

nature.com

A metabolic safety valve for reductive stress - Nature Metabolism

The glycerol-3-phosphate shuttle links redox balance to lipid synthesis, making the relief of reductive stress costly. Pan et al. rewire this circuit with a bifunctional enzyme that uncouples NAD⁺ reg...

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Melanie McReynolds @drohsopretty.bsky.social · 10/02/2026

Huge congratulations to Dr. Abrar Alsaadi on successfully defending her dissertation! My first PhD graduate—an incredible milestone for her, for me, and for the McReynolds Lab. So proud of the scientist and leader she has become. Onwards and upwards.!

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Reposted by Melanie McReynolds

HHMI @hhmi-science.bsky.social · 18/01/2026

Driven by an experience familiar to many — watching parents age — HHMI Hanna Gray Fellow Melanie McReynolds wants to answer a fundamental question: How can we age healthier? The key may lie in better understanding NAD+ & how its levels decline as we grow older. Via @asbmb.bsky.social: bit.ly/45tDuHB

Melanie McReynolds and her former Ph.D. mentor, Wendy Hanna–Rose, examine a specimen using a light microscope in McReynolds’s lab at Penn State in 2025.

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Melanie McReynolds @drohsopretty.bsky.social · 25/11/2025

Huge congratulations to our ABRCMS 2025 award winners! 🏆✨ • Isaiah Diggs – Outstanding Poster Presentation • Lily Williams – Outstanding Poster Presentation So proud of the excellence, dedication, and growth these two have shown since joining my lab as freshmen. They shined on the national stage!

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Melanie McReynolds @drohsopretty.bsky.social · 01/11/2025

So proud — like the soccer mom type of proud— of my senior undergrad Isaiah Diggs for winning a poster award at SACNAS!

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Reposted by Melanie McReynolds

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 09/10/2025

Today's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future. asbmb.org/membership

Eleven members of the ASBMB Membership Committee smile and pose for a group photo at ASBMB's offices. They are standing in front of a bookcase lined with issues of the Journal of Biological Chemistry.

Members of the ASBMB Membership Committee gather around a member who is holding a copy of the first issue of the Journal of Biological Chemistry, which was published in Oct. 1905. They issue of the journal is opened and two members are taking photos on their phones.

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Reposted by Melanie McReynolds

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 09/10/2025

Thank you to everyone who joined our recent committee meeting! #ASBMBJournals #JbiolChem 📸 Committee members here on #Bluesky: @chifungleephd.bsky.social, @marinaholz.bsky.social & @drohsopretty.bsky.social.

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Reposted by Melanie McReynolds

Harmit Singh Malik @harmitmalik.bsky.social · 15/10/2025

Excellent first day at @pennstateuniv.bsky.social for the Marker lectures hanging out with science celebrities @nicoleacrowley.bsky.social @drohsopretty.bsky.social @symbionticism.bsky.social plus several more folks I was too shy to ask for selfies

Dr. Melanie McReynolds, queen of all things NAD+ in biochem dept at Penn State

Selfie with Dr. Seth Birdenstein, direction of microbiome institute at Penn state

Selfie with Dr. Seth Bordenatwin showing off some nice swag (socks) that advertise the microbiome center at Penn State

Selfie with Dr. Nikki Crowley, director of neuroscience institute at Penn state

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Reposted by Melanie McReynolds

Eliseo Castillo @ecastillounmhsclab.bsky.social · 19/09/2025

A great collaboration with the @drohsopretty.bsky.social lab examining the gut-liver axis: the enteroendocrine cells, enterohormones, metabolites, and lipid changes in MASLD and MASH models.

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Melanie McReynolds @drohsopretty.bsky.social · 30/07/2025

In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator. Forever grateful to past and present members of my lab for helping me accomplish this dream.

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