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Aman Husbands

@husbandslab.bsky.social
666 followers 369 following 262 posts

Assistant Professor, Univ of Pennsylvania. Plant developmental biology, robustness, evolution, transcription factors, Bajan rum, LFC

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Aman Husbands @husbandslab.bsky.social · 02/07/2026
Been away from BlueSky for a bit but just received tenure! Big thank you to my many many mentors and colleagues. And, of course, my family. Truly a team effort. Also, this video took like six tries to get right 🫠
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Kai A. James @kaijamesyyz.bsky.social · 26/05/2026
How was the wheel invented? I discussed this in my first ever article for @us.theconversation.com Check it out. theconversation.com/how-was-the-...
theconversation.com
How was the wheel invented? Computer simulations reveal the unlikely birth of a world-changing technology nearly 6,000 years ago
People have long assumed that wheels evolved from simple wooden rollers. But how? And why? A new model focused on mechanical advantage and structural strength suggests some answers.
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Aman Husbands @husbandslab.bsky.social · 10/04/2026
I have a thousand positive memories of Greg. At the bar, playing music, talking science. RIP and thank you for everything
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Adrienne Roeder Lab @roederlab.bsky.social · 23/02/2026
How moss makes a spiral of leaves through a rotating asymmetric division of the apical cell meristem--our paper is out @currentbiology.bsky.social today! @soestrauss.bsky.social Richard Smith, Joe Cammarata www.cell.com/current-biol...
cell.com
Spiral phyllotaxis in the moss Physcomitrium patens emerges from simple division rules of the apical cell
Cammarata et al. explore how cell division orientation generates phyllotaxis in moss with a unicellular meristem. They show that successive rotational divisions in the apical cell are precisely placed...
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Adrienne Roeder Lab @roederlab.bsky.social · 09/02/2026
This was a fun project for which Mattie @mschwall95.bsky.social visited our lab to try root live imaging. Of course the roots wouldn't grow during the week she was here until the last day, but she got it to work when she got back. Cool results.
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Aman Husbands @husbandslab.bsky.social · 09/02/2026
Thanks for the invitation, Sunil! Very nice to be back. Also, it was 79 degrees in Riverside and Philly was like 0 degrees, so….yeah😂
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Aman Husbands @husbandslab.bsky.social · 07/02/2026
Thanks Carolyn! Very nice to be back in my old stomping grounds 😄
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José Dinneny @josedinneny.bsky.social · 04/02/2026
Excited to share our latest review on hydrosignaling: moisture-dependent molecular pathways that help plants grow towards water. Insightful review of the literature and discussion of moisture sensing mechanisms by Will Dwyer and @hhtormar.bsky.social. Enjoy! link.springer.com/article/10.1...
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Jenna Norton @jenna-m-norton.bsky.social · 03/02/2026
Please stop saying the bill allows "no more multi-year funding" - or at least be clear the 'more' is in reference to disastrous FY25 levels. The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research. The bill has some wins. MYF is not one of them.
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Peter Etchells @peteretchells.bsky.social · 02/02/2026
Given the described activators of cambium growth, we reasoned repressors were needed to balance the system. Here they are! www.biorxiv.org/content/10.6... Discovery: Xing, Jingyi, Emma, Riikka, Anne-Maarit, Julia, Qing, Hanan, Raluca, Joanna, Yuqi, Wiki #plantscience #plantdev
biorxiv.org
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Jill Harrison @jillharrison.bsky.social · 02/02/2026
It was good to catch up on my reading for this dispatch in Current Biology. Sjoerd Woudenberg in the Weijers lab, Wallner et al. In the Dolan lab and Flores Sandoval et al. In the Bowman lab have done a great job! Evolution and development: What makes a merry stem?: www.cell.com/current-biol...
cell.com
Evolution and development: What makes a merry stem?
From tiny mosses to giant redwoods, around 450,000 species of land plants show a huge variety of forms, yet all land plants develop from stem cells in proliferative meristems. What makes a meristem? T...
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Xuebing Wu @xuebingwu.bsky.social · 31/01/2026
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
biorxiv.org
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Ben Williams @benpwilliams.bsky.social · 29/01/2026
Absolutely delighted that our paper on epigenetic dynamics during plant aging is out today in Science! www.science.org/doi/10.1126/...
science.org
Aging drives a program of DNA methylation decay in plant organs
Plants display a wide range of life spans and aging rates. Although dynamic changes to DNA methylation are a hallmark of aging in mammals, it is unclear whether similar molecular signatures reflect ra...
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New Phytologist @newphyt.bsky.social · 28/01/2026
XTH genes impact growth habit determination of twining common bean vine revealed by brassinosteroid treatment Hunt et al. nph.onlinelibrary.wiley.com/share/FVDTFB...
Effects of exogenous brassinosteroid manipulation on bean stem morphology and anatomy.
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Penelope Lindsay @penlindsay.bsky.social · 26/01/2026
nph.onlinelibrary.wiley.com/share/JAIVZX... Excited to share my latest work in @newphyt.bsky.social. Here, we used TurboID proximity labeling with CLAVATA receptors FEA3 and BAM1D in maize meristems to better understand the signaling pathways important for meristem regulation. #PlantScience
image of a maize inflorescence meristem that is labeled by the plasma membrane marker PIP2-CFP and BAM1D-YFP.
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Adrienne Roeder Lab @roederlab.bsky.social · 24/01/2026
Thanks Vincent E. Cerbantez-Bueno for a great conversation. @naascarabidopsis.bsky.social www.arabidopsiscommunity.org/news-events/...
arabidopsiscommunity.org
Adrienne Roeder and her love of visualizing plant development — Arabidopsis Community as supported by NAASC
Vincent Cerbantez-Bueno, elected as a NAASC Early Career Scholar in 2024, interviews former NAASC faculty member Adrienne Roeder about her career: her background and personal journey to becoming a pla...
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Aman Husbands @husbandslab.bsky.social · 24/01/2026
Congrats to my colleague Doris Wagner and her excellent team! Special shout to Tian Huang for his outstanding work
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Maddy Seale @maddyseale.bsky.social · 23/01/2026
Out First Release in @science.org this week: A feedback loop allows two shoot stem cell populations to respond differently to environmental conditions: www.science.org/doi/10.1126/... #plantscience
science.org
A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy
Inflorescences of flowering plants adopt diverse genetically programmed and environmentally tuned architectures. By contrast, continued maintenance of the stem-cell pool within the apical meristem is ...
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bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 24/01/2026
A developmental timer coordinates organism-wide microRNA transcription www.biorxiv.org/content/10.64898/20…
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Facundo Romani @fromani.bsky.social · 23/01/2026
This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience
journals.plos.org
Chromatin state architecture governs transcription factor accessibility across plant genomes
Author summary In eukaryotes, DNA is tightly associated with histone proteins. Histone covalent modifications and histones isoforms, also called histone variants provide most of the complexity of chro...
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New Phytologist @newphyt.bsky.social · 22/01/2026
Functional and developmental differences between adaxial and abaxial #stomata in amphistomatous #leaves A #ResearchReview by @hanna-horak.bsky.social 👇 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... #LatestIssue
Fig. 1 Different light responses of adaxial and abaxial stomata in a dicot leaf.
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Jenna Norton @jenna-m-norton.bsky.social · 21/01/2026
If we continue to compromise with people whose stated goal is to destroy NIH, then we will not be successful in saving it.
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David Ho @davidho.bsky.social · 20/01/2026
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.
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Craig Kaplan @triggerloop.bsky.social · 20/01/2026
Paper is here and preview is below. This is case where the long back and forth between authors and reviewers is illuminating and touches on the historical literature elifesciences.org/articles/105...
elifesciences.org
Short activation domains control chromatin association of transcription factors
Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
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Chenxin Li, PhD @chenxinli2.bsky.social · 19/01/2026
Someone got Cas9-Turbo to work. It's like basically Y1H but with proteomics. It however requires transgenic plant expressing Cas9-Turbo and gRNAs, which is still cumbersome for many plants that are not Arabidopsis. #PlantSciences
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Facundo Romani @fromani.bsky.social · 17/01/2026
Happy to share the pre-print on GEMMIFER, a novel ERF required for the initiation of gemma in Marchantia. One of the coolest phenotypes that I have ever seen. Congratulations to Yuki and Go, who led this research. #PlantScience @biorxiv-plants.bsky.social www.biorxiv.org/content/10.6...
A Marchantia gemmaling producing ectopic vegetative propagules
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Pam Ronald @pcronald.bsky.social · 17/01/2026
NSF needs to hear from you. Among other points, I suggested: keep politics out of science; stop using the threat of cancelling scientific grants to try to control universities; increase NSF funding for fundamental research. Pls send around. Deadline is January 27. Thanks www.nsf.gov/od/updates/n...
nsf.gov
NSF seeks public input on its Fiscal Year (FY) 2026–2030 NSF Strategic Plan
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Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 15/01/2026
We should only fund research that will have huge impact and not fund research that won't. Fortunately, these are easy to distinguish. - Populists anytime they look at government research funding
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Aman Husbands @husbandslab.bsky.social · 14/01/2026
💀😂
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Liz Haswell @ehaswell.bsky.social · 10/01/2026
In the latest on Unprofessoring, I argue that I--and we--need ways to talk about the sensations of thinking and learning! unprofessoring.substack.com/p/towards-a-...
Grey background with light grey stars sprinkled on. It reads "Towards a langauge of the mind: How and why to describe the visceral pleasures of thinking"
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Alice Ting @aliceyting.bsky.social · 08/01/2026
Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
science.org
Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
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edgardemesa.bsky.social @edgardemesa.bsky.social · 08/01/2026
It's finally out!... Using single-cell and spatial transcriptome data, and data imputation, we created BARVISTA, a website able to perform almost genome-wide information on gene expression profiles at single-cell resolution in barley spikes! www.nature.com/articles/s41...
nature.com
Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development - Nature Plants
Spatially resolved gene expression during barley development was done by integrating an scRNA-seq dataset from cells with unknown position with spatial transcriptomics. This dataset is publicly availa...
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Hajk-Georg Drost @hajkdrost.bsky.social · 07/01/2026
🧵 Just out in Cell after more than 10 years in the making! 🎓 www.cell.com/cell/fulltex... Plants and animals evolve radically different body plans. Do they also operate under fundamentally different molecular evolutionary constraints during organ formation? @cellpress.bsky.social
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MadScientist @mads100tist.bsky.social · 29/12/2025
This is why we always have to push back. This is why we don't take breadcrumbs: either we all make it, or no deal. No complacency, only sense of duty and community 🧪
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Science Magazine @science.org · 29/12/2025
The U.S. NSF has announced changes to its highly regarded system of reviewing the some 50,000 grant proposals received each year. The move has created uncertainty and anxiety across the U.S. scientific community. Here are five things to know about the changes. ⬇️ scim.ag/4aCoSZQ
scim.ag
Five things to know about NSF’s new rules on merit review
Fewer outsiders, less feedback, and an uncertain fate for a new science board report
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Arif Ashraf @aribidopsis.bsky.social · 27/12/2025
New episode of #No_Time_To_Read_podcast! 🎙️ I had a wonderful discussion with @ajeetchaudhary.bsky.social Ajeet about his recent Molecular Plant paper. His work made it to the cover as well. Podcast: tinyurl.com/3ppeys36 Article: www.cell.com/molecular-pl...
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Aman Husbands @husbandslab.bsky.social · 27/12/2025
Dr. No: how to tell your PI to chill out cuz you just passed candidacy and you totally got this
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Aman Husbands @husbandslab.bsky.social · 26/12/2025
Post tenure, my research will be exclusively on zany shit like this ☺️
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Chenxin Li, PhD @chenxinli2.bsky.social · 24/12/2025
“In this study, we identified independent loss-of-function mutations in a WUSCHEL-LIKE HOMEOBOX transcription factor, WOX1, as the genetic basis of the prickleless S locus in both blackberry and red raspberry”
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Arif Ashraf @aribidopsis.bsky.social · 23/12/2025
(1/3) Any problem we see around us, somewhere some organism is smart enough to solve this problem already Here is a great example from liquid-stabilizing mechanisms of pitcher plants; Science Advances www.science.org/doi/10.1126/...
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Development @dev-journal.bsky.social · 23/12/2025
TMO5 orchestrates organ patterning in plant shoots This Research Highlight showcases work by Abdul Kareem, Carolyn Ohno and Marcus Heisler (@heisler-lab.bsky.social): journals.biologists.com/dev/article/...
TMO5 promotes PIN1 polarity convergence and organogenesis independent of MP. (A-C) Activation of PIN1-CFP expression (intensity-based colouring; the look-up table displays the signal intensity range), convergence formation and organ outgrowth in mp mutant shoot meristems after clonal activation of TMO5-2YPET (green). Panels A and B show the same meristem over time, whereas panel C presents a representative meristem (n=27). (D,E) Flower formation on mp pin-like inflorescence meristem following clonal activation of TMO5-2YPET (n=10). (F-J) No effect on PIN1 localization or organ outgrowth in mp mutant meristems with local activation of DOF5.8-YPET (F-H; n=12) or TMO6-YPET (I,J; n=15). Inset in G shows the meristem with the PIN1-CFP channel alone for clearer visualization. (K-M) Time-lapse images of the same mp mutant meristem region from 1 to 6 days after TMO5 clone formation, showing PIN1-GFP polarization in neighbouring cells towards the clones. The dashed box in K marks the area shown in L and M. Arrows indicate polarity (n=13). (N) PIN1-GFP polarization towards a TMO5 clone lacking organ outgrowth (n=9). (O,P) PIN1-CFP convergence in epidermal TMO5-expressing clones and polarized PIN1 in neighbouring cells in the mp mutant meristem at two time points of the same clones. Lower panels show longitudinal sections. Arrows indicate polarity; arrowhead in P marks sub-epidermal PIN1 expression (n=24). (Q) Two distinct organ outgrowths with epidermal PIN1 convergence induced by epidermal (left) or sub-epidermal (right) TMO5 clones. Lower panels show longitudinal sections. White arrowhead marks PIN1 activation in sub-epidermal cells; orange arrowhead marks sub-epidermal TMO5 clones. Dashed line marks the outgrowth boundary (n=5). Scale bars: 20 µm (A-C,F,G,I-Q); 1 mm (D,E,H).
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 19/12/2025
Hey all, I reached out to the PO of my NIGMS MIRA to ask if the gov't shut down, and rescheduling of study sections, might allow for some accommodation to the standard rule that PIs cannot resubmit a MIRA while their MIRA (or other RPG) is under review (waiting in scores or summary statements) 🧪
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Dave Baltrus 🦦 @surtlab.bsky.social · 18/12/2025
Live thread of the NSF biology virtual office hour: 🧵
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New Phytologist @newphyt.bsky.social · 16/12/2025
Fusion genes as emerging regulators of plant development and adaptation Hamid et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Research scope on fusion genes in plants.
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Chenxin Li, PhD @chenxinli2.bsky.social · 16/12/2025
"cis-regulatory evolution involves turnover of thousands of individual binding site instances while largely preserving transcription factors’ binding preferences." From: academic.oup.com/mbe/advance-...
academic.oup.com
Widespread turnover of a conserved cis-regulatory code across 589 grass species
Abstract. The growing availability of genomes from non-model organisms offers new opportunities to identify functional loci underlying trait variation thro
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Sean Montgomery @seanamontgomery.bsky.social · 15/12/2025
Bryophyte-friendly tenure-track position in the UBC Botany department! Deadline on the 19th botany.ubc.ca/job-postings...
botany.ubc.ca
UBC
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Thomas Greb @thomasgreb.bsky.social · 15/12/2025
A very nice and skillful work by Agata Burian and colleagues characterizing the development of vascular strands around the Arabidopsis shoot apex: www.sciencedirect.com/science/arti...
sciencedirect.com
Self-organization of vascular strands drives their patterning in the Arabidopsis shoot apex
In plants, the development of the shoot vascular system is closely coordinated with lateral organ formation at the shoot apical meristem. Despite exte…
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Rémi Fronzes @fronzeslab.bsky.social · 14/12/2025
So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think. Same applies to LLMs for scientific writing.
nature.com
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
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Harmit Singh Malik @harmitmalik.bsky.social · 13/12/2025
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
biorxiv.org
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
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