The populations with the largest treatment gaps are not necessarily those that could achieve the greatest absolute reduction in cardiovascular risk through treating individuals who are currently untre...

Large networks are particularly beneficial to researchers in under-represented groups.

Artificial intelligence is poised to reshape clinical trials, addressing challenges in design, recruitment, monitoring and conduct. This Review outlines a framework built on deeply phenotyped cohorts,...

More than 15 years ago, the original Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) provided one of the first prospective, multinational descriptions of acute heart failure in sub-Saharan Afri...

Sustained cerebral arteriole dilation requires ORAI1-mediated Ca2+ influx in capillary endothelial cells.

Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...

BACKGROUND: Cardiovascular disease is a leading cause of global mortality. Carotid-femoral pulse wave velocity (cfPWV) is the gold-standard noninvasive measure of arterial stiffness and is commonly us...

AbstractBackground. Left ventricular diastolic dysfunction (LVDD) is an early precursor to heart failure with preserved ejection fraction (HFpEF) and it is

The authors show that cerebral venous blood flow and meningeal lymphatics co-regulate intracranial pressure and brain clearance in mice and humans. This finding supports idiopathic intracranial hypert...

Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.

AbstractAims. Mutations in the LMNA gene, which encodes lamin A/C, cause a variety of diseases known as laminopathies. Some mutations are particularly asso

Nature Reviews Cardiology, Published online: 03 July 2026; doi:10.1038/s41569-026-01321-8The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.

In this Primer, Vaidya and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with primary aldosteronism, an important cause of hypertension res...

Pediatric Research - Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy

Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.

Amid chaos in US science and geopolitical turmoil, Europe wants to position itself as a research haven — but questions about funding and innovation remain.

Nature Reviews Cardiology, Published online: 19 June 2026; doi:10.1038/s41569-026-01313-8In this Review, Santovito and colleagues provide an overview of epigenetic regulation in atherosclerosis, focusing on how epigenetic modifications guide cell-specific transcriptional programmes in vascular endothelial cells, vascular smooth muscle cells, and immune cells to regulate cell plasticity and intercellular communication. They also discuss translational opportunities and the challenges of using epigenetic drugs to treat atherosclerotic cardiovascular disease.

Nature Reviews Cardiology, Published online: 15 June 2026; doi:10.1038/s41569-026-01316-5Researchers have developed a deep learning system that uses short videos of the face passively recorded during everyday use of smartphones to monitor heart rate and resting heart rate. The system was validated under laboratory and free-living conditions and across a range of skin tones.

Key PointsUBA1-mutated monocytes are susceptible to RIPK1-dependent cell death and display impaired NF-κB–mediated cytokine responses to TLR agonists.UBA1-

Background Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. Objective...

Nature Reviews Cardiology, Published online: 09 June 2026; doi:10.1038/s41569-026-01315-6In patients with advanced, symptomatic heart failure with reduced ejection fraction refractory to guideline-directed therapy, transplantation of a tissue allograft produced from induced pluripotent stem cells promotes heart remuscularization and leads to increases in heart wall thickness, left ventricular ejection fraction and quality of life at 3 months, according to an interim analysis of the ongoing, phase I–II BioVAT-HF clinical trial.

Nature Reviews Cardiology, Published online: 04 June 2026; doi:10.1038/s41569-026-01311-wA new study shows that the microtube network directs cardiomyocyte growth through two mechanisms: by redirecting the localization of mRNA and protein synthesis and by modifying the intercalated disc, the site of cell–cell adhesion at the ends of the cardiomyocyte.

A machine-learning model that uses smartphone cameras to measure heart rate in the background during normal daily phone use and subsequently estimate resting heart rate could make it easier for people to monitor heart health.

Women’s participation in science has risen sharply, but a Nature Index analysis finds that gender gaps in first and last authorship — markers of key scientific achievements — have barely shifted over the past decade.

Detecting secondary forms of hypertension is key to targeted management and prevention of cardiovascular complications. Primary aldosteronism (PA) is the most common form of secondary arterial hyperte...

Treatments aim to bulk up failing hearts to restore their vigour – but can the field move on from past controversy?

Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing and mortality and uncovers the modular architecture of ageing and mortality hallmarks.

Massive analyses of RNA transcripts from rodents, monkeys and humans reveal hallmarks of ageing that could expedite the development of anti-ageing interventions.

Nature Reviews Cardiology, Published online: 20 May 2026; doi:10.1038/s41569-026-01303-wIn this Obituary, Peter Libby reflects on the life and achievements of Eugene Braunwald, celebrated as the father of modern cardiology.

Sudden death remains a major global cause of mortality, yet recent European trends are poorly characterized. We analyzed sudden death mortality across…

Science sleuth Lonni Besançon realizes that he has sometimes misunderstood what the media want from him and his researcher colleagues.

Systems can generate hypotheses, interpret data and suggest ways to develop medicines.

Nature Reviews Cardiology, Published online: 18 May 2026; doi:10.1038/s41569-026-01300-zDilated cardiomyopathy is a major contributor to cardiovascular morbidity and mortality worldwide, with non-ischaemic aetiology reported in 30–40% of patients with heart failure. In this Review, Ramos-López and colleagues explore the complex epidemiology and genetic architecture of non-ischaemic dilated cardiomyopathy, reflect on the challenges of accurately assessing its prevalence and discuss environmental factors that modify disease penetrance and phenotype.

The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...

Nature - Health outcomes were better in people who slept between about six and eight hours a day.

Health outcomes were better in people who slept between about six and eight hours a day.