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Dr. Hannah E. Jones, PhD

@hejcell.bsky.social
575 followers 828 following 11 posts

PhD Cell Biology, Stem Cells & Development, fibroblasts n' brains n' vasculature, #embryo22, she/her

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Reposted by Dr. Hannah E. Jones, PhD
Simon Hammann @simonhammann.bsky.social · 20/04/2026
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.
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Siegenthaler Lab @siegenthalerlab.bsky.social · 07/04/2026
Congrats to the newest PhD from the @siegenthalerlab.bsky.social, Dr. Sophia Kim! Beautiful thesis document & presentation! 🧠🦠🔬🎉 Sophia's thesis work on arachnoid barrier breakdown in meningitis is on bioRxiv - check it out! www.biorxiv.org/content/10.6...
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Siegenthaler Lab @siegenthalerlab.bsky.social · 06/03/2026
🚨 New preprint from our lab led by Sophia Kim w/ @kellydoran.bsky.social group @cuanschutz.bsky.social -- using neonatal 🐭 model of bacterial meningitis ➡️ arachnoid barrier is leaky, Cldn11 junctions are disrupted & cytokines are part of the problem. Lots of 🤩🧠🦠🔬 & compelling data, check it out! 1/5
graphical schematic of the meninges on top depicting the three layers [dura, arachnoid and pia] and other immune and vascular cell types. Inset shows Claudin-11 junction proteins connecting two sides of arachnoid barrier cells

bottom schematic is the same but in inflammation with bacteria, junctions breakdown, depiction of cytokine release by vascular, meningeal and immune cells - at side of graphic is summary of defects we observe in infection: 'increased barrier permeability' 'mislocalization of Cldn11+ tight junction' 'BAM activation' and "increased inflammatory response'
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bioRxivpreprint @biorxivpreprint.bsky.social · 16/02/2026
Conserved cellular architecture and developmental mechanisms of the zebrafish www.biorxiv.org/content/10.64898/20…
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Reposted by Dr. Hannah E. Jones, PhD
Leon Smyth @leonsmyth.bsky.social · 02/12/2025
Excited to share my final postdoc project published. We looked into the striking amyloidosis of important brain waste clearance sites (bridging veins) in mouse and human. A great collaborative project with Rupal Mehta at Rush who did all the human studies. Thanks to everyone who contributed!
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Reposted by Dr. Hannah E. Jones, PhD
Hao Yin @haoyin.bsky.social · 21/11/2025
Postnatal Cerebral Perivascular Fibroblast #SciArt Fibroblast PDGFRα KO🐭(P0) 👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10) 👉↔️SMC/Astrocyte coverage @hejcell.bsky.social @siegenthalerlab.bsky.social @devbiol.bsky.social 2025 www.sciencedirect.com/science/arti...
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Dr. Hannah E. Jones, PhD @hejcell.bsky.social · 20/11/2025
& a great time to share a life update! (better late than never) I’ve recently started as a Postdoc in the Wills lab at University of Washington where I’ll be studying the role of fibroblasts during regeneration in Xenopus 🐸🧠 On my way to becoming a frog wrangler @frogwranglers.bsky.social
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Dr. Hannah E. Jones, PhD @hejcell.bsky.social · 20/11/2025
Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
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Siegenthaler Lab @siegenthalerlab.bsky.social · 20/11/2025
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Micrscopy images of cleared cerebral brain tissue showing penetrating blood vessels (white) in mice - magenta cells are perivascular fibroblasts and cyan cells are perivascular macrophages - in control mice, both cell types are near the vessel termini by postnatal day 10 but in 'cKO' mice that lack expression of a tyrosine kinase receptor PDGFRa in fibroblasts, both the fibroblasts and macrophages are only partially covering the vessels. From Figure 4 of our paper - https://authors.elsevier.com/a/1m7fa2mzTkyfS
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John Wallingford @jbwallingford.bsky.social · 19/11/2025
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
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Dr. Lucky Tran @luckytran.com · 01/10/2025
"If we lose hope, we're doomed." We must continue Dr. Jane Goodall's mission and all fight for the future of the planet.
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Randall Munroe @xkcd.com · 25/04/2025
PhD Timeline xkcd.com/3081
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Siegenthaler Lab @siegenthalerlab.bsky.social · 12/04/2025
@cshlmeetings.bsky.social Brain Barriers 2025 is a wrap! It was an honor to co-organize this meeting in 2023 & 2025, a highlight of my scientific career. I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!
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Sidar Aydın @sidaraydin.bsky.social · 12/04/2025
🚨 A new Daneman Lab preprint!! 🚨 Reid Larsen, one of the brightest scientists I know, studied the BBB glycocalyx, identified its structure, composition, and function and uncovered what makes the CNS glycocalyx unique. It was a true pleasure to be a part of this seminal study! shorturl.at/Wkhxr
biorxiv.org
Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx
The blood-brain barrier (BBB) glycocalyx is the dense layer of glycans and glycoconjugates that coats the luminal surface of the central nervous system (CNS) vasculature. Despite being the first point...
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Reposted by Dr. Hannah E. Jones, PhD
Siegenthaler Lab @siegenthalerlab.bsky.social · 17/03/2025
I was imaging this weekend, took this image because it was beautiful to me, the blood vessels, fibroblasts, astrocytes, & macrophages as steadfast guardians at the brain's edges. Cheers to the 'guardians' of all that is important. ❤️
microscope image of a postnatal mouse brain showing the entry point of blood vessel into the brain - fibroblasts (yellow: S100a6) form a layer at the brain's edge (meninges) and surround the blood vessel. Astrocyte endfeet (magenta, GFAP) form a layer at the brain's edge, apposed to the fibroblasts. Image also shows macrophages (cyan; CD206) and cell nuclei (DAPI, blue)
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beetle moses @beetlemoses.bsky.social · 13/03/2025
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Missy Hubbard @missy-ubermom.bsky.social · 08/03/2025
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Christophe 🔬 Leterrier @christlet.bsky.social · 07/03/2025
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
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Dr. Hannah E. Jones, PhD @hejcell.bsky.social · 07/03/2025
we’re standing up for science tomorrow! Made some signs tonight with Denver @standupforscience.bsky.social organizers ❤️🧬🔬🥼
 sign that says in block letters “this machine kills fascists” with a cartoon of a micropipette in the center “protect diversity & equity in STEM” written in block letters, below a cartoon of a gloved hand holding a micropipette overlaid with the female gender symbol sign with hand written bold letters saying “vaccines cause adults” sign with hand written bold letters saying “mRNA is literally already inside of you”
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Julia Willett @jlewillett.bsky.social · 01/03/2025
"downsizes" is a weak way of saying "forced to cancel dozens of programs, which jeopardizes future STEM careers of talented undergrads" @science.org www.science.org/content/arti...
science.org
NSF downsizes summer research program for undergraduates
Many participants are from groups underrepresented in science
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 27/02/2025
"Memoli had no choice, he insisted: He was following the direction of three HHS officials—Dorothy Fink, then the acting secretary; Heather Flick Melanson, chief of staff; and Hannah Anderson, deputy chief of staff of policy—who told him, in no uncertain terms, that the pause was to continue..." /1
theatlantic.com
Inside the Collapse at the NIH
Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Kyle Clark @kylec.bsky.social · 21/02/2025
A small museum says all but one sponsor of a Girls in STEM event backed out, fearing retaliation from the Trump administration over "DEI." Evan Kruegel reports for @nexton9news.bsky.social. www.youtube.com/watch?v=Zg1n...
youtube.com
Sponsors pull out of 'Girls in Science' event at Colorado children’s museum following DEI cuts
YouTube video by Next 9NEWS
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CantlonLab @cantlonlab.bsky.social · 18/02/2025
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
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Ben Collins @bencollins.bsky.social · 17/02/2025
Maybe I wasn’t clear about this. I wanted more egg and no plane crash, not many plane crash and no egg.
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University of Colorado Anschutz @cuanschutz.bsky.social · 17/02/2025
“It’s really an elaborate infrastructure that’s required to do this research. One of the things that concerns me is the magnitude and rapidity of these changes.” VC for Research Tom Flaig, MD, recently spoke to @cbsnews.com about the potential impact the proposed NIH cuts could have on our campus.
cbsnews.com
Colorado's large medical research community deals with attempts to cut federal funding
Colorado's medical research community is looking at how to handle the potential of cuts to research grant money that it receives from the National Institutes of Health.
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Reposted by Dr. Hannah E. Jones, PhD
Dr Zoë Ayres @zjayres.bsky.social · 11/02/2025
On International Day of Women and Girls in Science, a reminder to not close your eyes and turn away from what is happening in the US right now. Fascism is an assault on scientific integrity, knowledge, and innovation. www.chron.com/news/space/a...
chron.com
NASA to wipe mentions of women, Indigenous people from websites
NASA employees told to remove mentions of women, indigenous people, and environmental justice from websites.
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Maureen Barr @barrlab.bsky.social · 08/02/2025
March for science? AAUP & other unions are working on action plans and messaging around NIH, DEI, and other slashes Feb 13: National call in 8PM (below) Feb 19: National day of action on campuses (details soon) Feb 25: National Action & Press Conference in DC (details soon) @aaup.bsky.social
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Daniel Colón-Ramos @dacolon.bsky.social · 08/02/2025
I have not seen a crisis of this magnitude since yesterday
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Beth Popp Berman @epopppp.bsky.social · 04/02/2025
The number of people surprised by the long list of words NSF is targeting makes me think many of you all have not seen this: www.commerce.senate.gov/services/fil...
maybe 250 words describing status250-ish social justice wordssmaller text -- 400 words on social justice and gender?And another 150 or so on race
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Bill Cresko @wcresko.bsky.social · 04/02/2025
Are you interested in seahorses, sea dragons and pipefish? And single cell transcriptomics? And evolutionary genomics? Check out the version of record from our latest paper at eLife led by the awesome Dr. Hope Healey elifesciences.org/articles/97764
elifesciences.org
Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes
The production of a single-cell atlas for developing syngnathid fish permits study of their unique traits.
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Society for Developmental Biology @socdevbio.bsky.social · 29/01/2025
The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.
Scientific research is a driving force behind human progress. It fuels medical breakthroughs, spurs technological innovations and drives economic growth. Federal funding of research by the National Institutes of Health (NIH) and the National Science Foundation (NSF) is absolutely critical for ensuring that the U.S. maintains its global leadership in science and technology.
The unprecedented freeze on the review and issuance of federal research grants is already negatively impacting research and could have significant ripple effects. Ongoing studies may lose momentum if grant renewals or supplement requests are delayed, slowing scientific progress on research the NIH has already invested in. Researchers affiliated with the Society for Developmental Biology carry out critical research on birth defects, which kill twice as many children as cancer does. Slowed progress will delay the development of new therapies and diagnostics, and thus have real public health implications. In 2019, the total estimated cost of birth defect–associated hospitalizations was $22.2 billion.
Scientific research is also critical to the U.S. economy more broadly. In 2023 alone NIH funded research not only directly supported 412 thousand jobs, but its overall economic impact rippled out to all sectors of the economy driving more than $92.89 billion in economic activity across all 50 U.S. states and the District of Columbia. It is estimated that every dollar of NIH funding generates $2.46 dollars of economic activity.
Finally, federal research funding not only drives impactful research discoveries but also supports the training of the scientists, engineers, and innovators of the future. University laboratories, funded by federal grants, serve as essential training grounds for the next generation of researchers even as they push the boundaries of knowledge. This training prepares young scientists for leadership roles in both academia and industry, helping to ensure that the scientific workforce r…
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Science Magazine @science.org · 15/01/2025
The blood-brain barrier can prevent therapeutic drugs from reaching the brain. Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6
scim.ag
A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro
A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.
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Matt Sikora @mjsikora.bsky.social · 14/01/2025
New podcast alert! Project Bridge at @cuanschutz.bsky.social - our trainee-led public outreach group - is launching 'The Science Bridge' tomorrow (1/15)! Current trainees host shows that demystify science, the research process, & research careers. #AcademicSky 🧪 open.spotify.com/show/0Q0bn3G...
open.spotify.com
The Science Bridge
Podcast · Project Bridge at CU Anschutz · Join us as we explore groundbreaking research at the Anschutz Medical Campus in Aurora, Colorado. Hosted by current research trainees, this biweekly podcast d...
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Dr. Hannah E. Jones, PhD @hejcell.bsky.social · 09/01/2025
This course WILL change your life in the best ways! 🐭🐟🐸🪱🐙🪰 apply apply apply
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nora "the tea kobold" rude (they/them ze/hir) @nora.zone · 23/12/2024
when cats curl up so much their faces go upside down rt if you agree
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John Lukens @lukensjohnr.bsky.social · 23/12/2024
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages www.science.org/doi/full/10....
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Di Jiang @dijiang319.bsky.social · 21/12/2024
A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates www.science.org/doi/full/10....
science.org
Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.
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Michael Fischbach @mfgrp.bsky.social · 11/12/2024
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/12/2024
Lots of interest in this course and many at the CSHL conference asking for an extension of the deadline. So we are adding one more week until December 17!!
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Marine Biological Laboratory @mblscience.bsky.social · 18/10/2024
Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉 See you in Woods Hole! mbl.edu/courses 🧪🐙🦑🧠🐟
A flyer of all the 2025 Advanced Research Training Courses available at the Marine Biological Laboratory in Woods Hole, MA with course titles, dates, and application deadlines listed. Visit mbl.edu/courses for more information.
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Siegenthaler Lab @siegenthalerlab.bsky.social · 05/12/2024
@ondinecleaver.bsky.social gave the BEST talk yesterday @cuanschutz.bsky.social sharing this great work with the faculty & student in our CSD grad program - Ondine is an exceptional scientist & meeting with her was an 🤩 birthday gift! 🎁 Thanks to 🦋-less Dr. Hannah Jones for inviting & hosting!
Model – Lats1/2 suppression of Yap is critical for endothelial adaptation to flow. (A) Hemodynamic flow along the long axis of blood vessels causes shear stress along the ECs of the vessels, altering their cytoskeleton, junctions, and polarity. (B) In the presence of sustained blood flow, ECs in control conditions that have normal Hippo regulation and will facilitate: 1. normal elongation of endothelial cells, 2. Golgi polarization upstream of flow, and 3. remodeling of junctions occurs. (C) However, in Lats1/2 depleted conditions, the cytoskeleton is defective, and both Golgi polarization and junctional maturation are defective. Additionally, nuclear YAP/TAZ causes aberrant gene expression of cytoskeletal genes, cell adhesion genes, and Hippo target genes including CLDN5/11, NCAM1, MYL9, TGFB2, and integrins.
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Dr. Hannah E. Jones, PhD @hejcell.bsky.social · 05/12/2024
I am 🦋-less no longer! Had an awesome time hosting & talkin' tubes with @ondinecleaver.bsky.social yesterday!
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