A key requirement to address fundamental questions in developmental biology is the ability to visualise and manipulate endogenous signalling proteins in vivo. Here we generate such an enabling experim...

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...

The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...

Brown and prematurely falling leaves are currently a common sight in many forests. Depending on the tree species, this may be either a defensive reaction to water shortage or an indication that damage...

Plants strategically respond to gravity and actively set defined growth angles. These gravitropic set-point angles (GSAs) shape the width and depth...

Caroline Steel explores how synthetic biology is helping us to engineer life.

The tumor suppressor KDM6A/UTX, a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosp...

Creating accurate graphs and performing statistical analyses can be challenging for those who lack coding experience. This Community Page introduces grafify online, a free, browser-based app for generating publication-quality graphs and performing statistical tests and post-hoc comparisons.

We describe here an efficient method for gene editing in mouse T cells, based on well-established, high-efficiency retroviral transduction protocols. Our platform allows analysis of mutant phenotypes ...

VERNALIZATION2 (VRN2) is a flowering plant-specific subunit of the polycomb-repressive complex 2 (PRC2), a conserved eukaryotic holoenzyme that repres…

Oxygen availability underpins energy production in multicellular organisms, yet internal oxygen gradients arise in both plants and animals. Plants sense these variations via the plant cysteine oxidase...

A free browser extension that marks antibodies cited in a paper with their knockout-controlled validation status, for the application they were used in.

Plasmid Integrity by Complete Assembly and Rapid Determination sequencing (PICARD-seq) using ONT MinION. . Read full protocol, steps, and materials on protoc...

Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

Abstract. Recent discoveries have fundamentally transformed the paradigm of plant oxygen sensing. Hypoxia is no longer viewed solely because of environment

Closing date: Monday 21 September 2026, 23:59