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Gwen Knight

@gmknght.bsky.social
1K followers 128 following 55 posts

Prof of AMR research at London School of Hygiene and Tropical Medicine

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Reposted by Gwen Knight
London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 23/06/2026
Antimicrobial resistance is one of today's biggest global health challenges 🦠 Join our online short course (28 September–2 October 2026) to learn from global experts & gain practical knowledge to help tackle #AMR across policy, research & practice. Apply now 👉 www.lshtm.ac.uk/study/course...
Dark blue graphic with white text reading: Online short course, Antimicrobial Resistance (AMR): A Multidisciplinary Approach. Inset image shows researcher in white lab coat and blue cap and gloves in a lab transferring samples using a pipette.
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Reposted by Gwen Knight
LSHTM AMR Centre @lshtmamrcentre.bsky.social · 18/05/2026
A new study led by Harry Veillard, MSc student @lshtm.bsky.social, found that nurse and pharmacist prescribing could improve access to care, reduce treatment delays, and ease pressure on primary care. The study also highlights the need for training and support. Read more 👉 bit.ly/4tERrvi
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Gwen Knight @gmknght.bsky.social · 27/04/2026
Congratulations @rebeccaglover.bsky.social! really looking forward to working with you once back from Heidelberg.
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Reposted by Gwen Knight
LSHTM AMR Centre @lshtmamrcentre.bsky.social · 24/03/2026
Typhoid isn’t just a health issue, it’s an economic crisis. A new study led by researchers at @lshtm.bsky.social finds India loses ~$1.5 billion a year to typhoid, with millions of cases and rising antibiotic resistance. Read more 👉 www.lshtm.ac.uk/research/cen...
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Reposted by Gwen Knight
Microbiology Society @microbiologysociety.org · 16/03/2026
Vaccines don’t just prevent disease, they also help fight antimicrobial resistance (AMR) 💉 By reducing infections, vaccines reduce the need for antibiotics. Watch our short video on this: microb.io/4bp7IO5 #KOAMR #NationalVaccineDay #AMR
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Reposted by Gwen Knight
LSHTM AMR Centre @lshtmamrcentre.bsky.social · 11/02/2026
It’s International Day of Women & Girls in Science 🤗 Today, we celebrate Regina Ami Banu, who is advancing awareness, mentorship, and community engagement on #AMR in Ghana 🇬🇭 Read more 👉 www.lshtm.ac.uk/research/cen...
lshtm.ac.uk
Leading the fight against Antimicrobial Resistance in Ghana | LSHTM
Leading the fight against Antimicrobial Resistance in Ghana | LSHTM
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Reposted by Gwen Knight
Craig MacLean @craigmaclean.bsky.social · 20/02/2026
New pre-print with @wtmatlock.bsky.social!!! www.biorxiv.org/content/10.6... What shapes the distribution of plasmids across bacteria? Our paper shows that conjugative plasmids actually have a very narrow distribution compared to mobilizable plasmids. Conjugative systems restrict plasmid transfer!
biorxiv.org
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Christos C. Ioannou @ccioannou.bsky.social · 18/02/2026
📢📢📢Lectureships at Bristol!📢📢📢 We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline. Great department, great colleagues, great building, great city Details here: www.bristol.ac.uk/jobs/find/de...
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Reposted by Gwen Knight
Alvaro Schwalb @aschwalbc.bsky.social · 13/02/2026
1/📢 In our new publication, we estimate that in 2022, 134 million people worldwide had a recent Mycobacterium tuberculosis (Mtb) infection and were at high risk of progressing to TB disease. Read the full paper in PLOS Medicine (tinyurl.com/mtbinfection). #TBSky
tinyurl.com
Estimating the global burden of viable Mycobacterium tuberculosis infection: A mathematical modelling study
Alvaro Schwalb and colleagues conducted a mathematical modelling study to estimate the global burden of viable Mycobacterium tuberculosis--that which can cause disease and be transmitted--to help guid...
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Reposted by Gwen Knight
The Lancet Microbe @lancetmicrobe.bsky.social · 13/01/2026
New research article Sex-based differences in #Plasmodium infection in the control groups of controlled human malaria infection trials in #malaria naive populations in the USA and the Netherlands: a pooled analysis www.thelancet.com/journals/lan... #IDSky #ClinMicro #CHIM #OpenAccess #OA
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Gwen Knight @gmknght.bsky.social · 28/11/2025
Agree! super and so well organised thanks @microbiologysociety.org. Great to reconnect with @whelanfj.bsky.social and have a lovely dinner with new colleagues @padpadpadpad.bsky.social @paulhoskisson.bsky.social @magdalenakurteu.bsky.social
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Gwen Knight @gmknght.bsky.social · 26/11/2025
Excited to be in cold sunny Liverpool for #microevo25. Looking forward to an interesting day of microbial evolution talks! @microbiologysociety.org
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Reposted by Gwen Knight
Finn McQuaid @cfmcquaid.bsky.social · 18/11/2025
@lshtm-tbmod.bsky.social is offering multiple PhD opportunities through MRC LID, deadline 14 Jan. More details: mrc-lid.lshtm.ac.uk/applicants/ Projects include #1 TB & screening #2 TB & climate change #3 TB & vaccines #4 TB & influenza #5 TB & prevention @cmmid-lshtm.bsky.social @lshtm.bsky.social
mrc-lid.lshtm.ac.uk
Information for applicants - MRC London Intercollegiate Doctoral Training Partnership Studentships
MRC LID studentship information for applicants How to Apply Projects Studentship funding Studentship options Studentship...
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 24/11/2025
Join us for LSHTM’s Equity in AMR Action seminar, which explores how equity influences responses to AMR. Speakers will share their work from the WHO, LSE, and the Global Strategy Lab. 📅 12 Dec ⏲️ 13:00 GMT Check the event details 👇 www.lshtm.ac.uk/newsevents/e...
lshtm.ac.uk
Equity in AMR Action | LSHTM
In 2025, the Network’s seminar series invites 2-3 speakers for each event to present their work on a particular theme around prioritisation. This fourth seminar of the series presents ‘Equity in AMR
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Reposted by Gwen Knight
London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/11/2025
#Klebsiella infections are a serious & growing #PublicHealth threat For #AntimicrobialAwarenessWeek, @josebengoechea.bsky.social discusses the dangers of bacterial infections, antimicrobial resistance & the global efforts to tackle it. @lshtmamrcentre.bsky.social www.lshtm.ac.uk/newsevents/e...
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Katherine Horton @kchorton.bsky.social · 20/11/2025
All are welcome to join the Gender Equity in TB Working Group today at 12:30 in Room B4B @theunion.org! We'll share updates on working group activities and host a panel discussion on progress to date and ways forward to ensure an equitable and inclusive #TB response.
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Reposted by Gwen Knight
Kat Holt @katholt.bsky.social · 19/11/2025
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year. Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW doi.org/10.1101/2025...
figure showing estimated proportion of cases in clusters, for each site. range from 0.04 to 0.93, mean estimate in random effects model is 0.57 [0.46,0.68]
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Gwen Knight @gmknght.bsky.social · 19/11/2025
Why is the only statistical difference in resistant BSI by sex in the 15 to 44 age group where resistance was higher in females (21.4% vs 18.9%, 8.5 vs 5.5 per 100,000 population).....? 👩‍💻🤔 latest #ESPAUR report on AMR just out!
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 17/11/2025
Ahead of #WAAW2025, learn how our researchers are tackling AMR across 30 countries globally, spanning biology, clinical science, policy, modelling, and social sciences. Stay updated on our research, insights, & AMR action. Sign up for our newsletter: bit.ly/3X0SvvO
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Zoe Anne Dyson @msmicrobiocode.bsky.social · 13/11/2025
London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.
mrc-lid.lshtm.ac.uk
2026-27 Project (Dyson & Mostowy & Knight) - MRC London Intercollegiate Doctoral Training Partnership Studentships
PHACTS: Unravelling PHAge-baCTeria-host immune dynamicS to inform phage therapy SUPERVISORY TEAM Supervisor Dr Zoe Dyson...
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Gwen Knight @gmknght.bsky.social · 10/11/2025
Excited to say that we have a PhD project out on our age-sex research - looking at combinations of #AMR. With the fabulous @jodi-lindsay.bsky.social and Lanre Edun! Do get in touch for more information! mrc-lid.lshtm.ac.uk/2026-27-proj...
mrc-lid.lshtm.ac.uk
Projects - MRC London Intercollegiate Doctoral Training Partnership Studentships
2026-27 MRC LID POTENTIAL RESEARCH PROJECTS MRC LID is offering 40 distinct potential projects for...
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Reposted by Gwen Knight
London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 05/11/2025
Drug-resistant infections in Europe set to rise as populations age, study suggests @gmknght.bsky.social & Catrin Moore explain understanding demographics & infection trends will help design more effective ways of controlling & preventing drug-resistant infections. www.lshtm.ac.uk/newsevents/n...
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Gwen Knight @gmknght.bsky.social · 05/11/2025
How will population shifts affect the future burden of #AMR? 👶👩‍🦳 🧫 We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics. doi.org/10.1371/jour...
doi.org
Combining demographic shifts with age-based resistance prevalence to estimate future antimicrobial resistance burden in Europe and implications for targets: A modelling study
Author summary Why was this study done? Infections caused by bacteria that are resistant to antibiotics are a major and growing threat to public health. Older adults and men are at higher risk of...
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Rebecca Glover @rebeccaglover.bsky.social · 24/10/2025
Agata Pacho and I published an article on self care and UTIs/AMR this week! In Sociology of Health and Illness: onlinelibrary.wiley.com/doi/10.1111/.... @lshtmamrcentre.bsky.social
onlinelibrary.wiley.com
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Freya Harrison @friendlymicrobe.bsky.social · 15/10/2025
PhD opportunity in my lab: exploring how commensals and pathogens build biofilm communities on endotracheal (ventilator) tubes. Microbial ecology, medical microbiology and fancy imaging! Co-supervised with the fabulous Saskia Bakker and Jeremy Webb warwick.ac.uk/fac/cross_fa... #MicroSky
warwick.ac.uk
Dr Freya Harrison
Dr Freya Harrison
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 14/10/2025
🚀 Exciting news! Our Centre Director @katholt.bsky.social will be speaking at #AMR2026 on “AMRrules: Interpretive Standards for AMR Genotypes.” Don’t miss her insights🧬✨ 📅 23–25 March 2026 🔗 bit.ly/3SWzJUm #MicroSky #AMR #Genomics
bit.ly
Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies — 20260323
Highlighting the importance of genomic data in the fight against AMR
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Katherine Horton @kchorton.bsky.social · 12/10/2025
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries. bit.ly/4nbV492
medrxiv.org
A global analysis of patterns of tuberculosis exposure and transmission
Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...
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Reposted by Gwen Knight
Onisillos @onisillos.bsky.social · 14/10/2025
I don't want to seem too cynical, but I wrote this 4 years ago: "...it will come as little surprise if a similar report in a year's time will be almost indistinguishable from the current version." www.thelancet.com/journals/lan...
thelancet.com
Antimicrobial resistance: plus ça change
This issue marks the first anniversary of The Lancet Microbe. This has been a year of profound change during which the world has experienced the most consequential infectious disease outbreak of the p...
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Gwen Knight @gmknght.bsky.social · 13/10/2025
Great to see accounting for age and sex in the #AMR estimates from the latest WHO #AMR global burden report out today! www.who.int/publications...
who.int
Global antibiotic resistance surveillance report 2025
This new WHO report presents a global analysis of antibiotic resistance prevalence and trends, drawing on more than 23 million bacteriologically confirmed cases of bloodstream infections, urinary trac...
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Reposted by Gwen Knight
Rein Houben @reinhouben.bsky.social · 07/10/2025
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
medrxiv.org
Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening
Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...
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Reposted by Gwen Knight
LSHTM AMR Centre @lshtmamrcentre.bsky.social · 12/09/2025
Sepsis claims a life every 3 seconds. Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩‍⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍 👉 bit.ly/3Vh4NiG
bit.ly
World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial
World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial resistance | LSHTM
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 28/07/2025
Congratulations to Jody Phelan for receiving the prestigious @esmyco.bsky.social Gertrud Meissner Award for his groundbreaking work on drug resistant tuberculosis 👏🌍 Read more 👉 bit.ly/4mfGDjW
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Jody Phelan receives Gertrud Meissner Award | LSHTM
Jody Phelan receives Gertrud Meissner Award | LSHTM
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Gwen Knight @gmknght.bsky.social · 11/07/2025
Been thinking about bedaquiline resistance in TB a lot lately... and today I was wondering about other mathematical models... so I went back to this figure that I still love from a few years ago showing how in #AMR #TB modelling showing most is just RR-TB - lots to be done!
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Gwen Knight @gmknght.bsky.social · 09/07/2025
Unfortunately, we're going to have to reschedule this talk - if you have a free hour then do go back and check our some of our past seminars across the #AMR disciplines! www.lshtm.ac.uk/research/cen...
lshtm.ac.uk
Events | LSHTM
Events | LSHTM
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Gwen Knight @gmknght.bsky.social · 08/07/2025
Really looking forward to hear this high level overview of #AMR policy from a great female scientist! Tomorrow - UK - lunch time 👩‍💻
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Gwen Knight @gmknght.bsky.social · 04/07/2025
A Friday reminder of this talk next Wednesday. I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!
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Katherine Horton @kchorton.bsky.social · 04/07/2025
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials. doi.org/10.1016/S221... @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 20/06/2025
LSHTM's Director writes to UK Government about #Gaza public health catastrophe Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster: 👉 www.lshtm.ac.uk/newsevents/n...
Palestinians fleeing northern Gaza on 9 November 2023 amid Israel's bombardment and siege of the enclave, and intense fighting between the Israeli military and Hamas fighters in the north. Credit: Mohammed Zaanoun/TNH
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Kat Holt @katholt.bsky.social · 01/07/2025
I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’ doi.org/10.1101/2025...
doi.org
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...
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Michael Brockhurst @brockhurstlab.bsky.social · 30/06/2025
One week left to submit your abstract to @microbiologysociety.org meeting on “Understanding and Predicting Microbial Evolutionary Dynamics” at Liverpool 26-27 November Lots of spaces for ECR talks and posters! microbiologysociety.org/event/societ...
microbiologysociety.org
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Gwen Knight @gmknght.bsky.social · 30/06/2025
The complexity of #AMR is rarely understated but few studies tackle the selection vs. transmission challenge. That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....
doi.org
Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards
Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 26/06/2025
In this blog, our Student Liaison Officer @lshtm.bsky.social, Brandon Hill, explores the often-overlooked intersection between #AMR and #LGBTQ+ health, highlighting the need for more inclusive data and policies to address health inequities. Read more 👇 bit.ly/3HYkp7e
bit.ly
Exploring the social determinants of AMR | LSHTM
Exploring the social determinants of AMR | LSHTM
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Gwen Knight @gmknght.bsky.social · 24/06/2025
Great to see this review of modelling for IPC & healthcare epi. - we had great discussions at the Think Tank! Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩‍💻🏥 pubmed.ncbi.nlm.nih.gov/39228083/
pubmed.ncbi.nlm.nih.gov
Expanding the use of mathematical modeling in healthcare epidemiology and infection prevention and control - PubMed
During the coronavirus disease 2019 pandemic, mathematical modeling has been widely used to understand epidemiological burden, trends, and transmission dynamics, to facilitate policy decisions, and, t...
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Gwen Knight @gmknght.bsky.social · 20/06/2025
So great to see this 🦣 effort finally published! Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team! Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR. gh.bmj.com/content/10/6...
gh.bmj.com
The global economic burden of antibiotic-resistant infections and the potential impact of bacterial vaccines: a modelling study
Introduction Antibiotic resistance (ABR) may increase hospital costs, utility loss and mortality risk per patient. Understanding these losses at national, regional and global scales is necessary for e...
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Gwen Knight @gmknght.bsky.social · 19/06/2025
Great combination of modelling and experimental data to better understand dynamic antibiotic exposure and #AMR And "fitness seascapes" 🌊 doi.org/10.1126/scia...
doi.org
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Kat Holt @katholt.bsky.social · 10/06/2025
Get your travel vaccines! 🌏💉 Typhoid vax is very effective BUT only lasts a few years so think about it EVERY time you travel. Most cases are antibiotic resistant, so don’t think you can just take a pill 💊 if you get sick. More and more, resistant cases need hospitalisation & intravenous antibiotics
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Gwen Knight @gmknght.bsky.social · 10/06/2025
Very excited for this event on the 9th July! It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 09/06/2025
🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR. In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy. 📅 9 July 2025 🕰️ 13:00 BST 📍 Online 🔗 bit.ly/4kVSVgP
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Kat Holt @katholt.bsky.social · 22/05/2025
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight) interpretamr.github.io/AMRrules
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LSHTM AMR Centre @lshtmamrcentre.bsky.social · 05/06/2025
Researchers at @lshtm.bsky.social, led by @josebengoechea.bsky.social, will conduct a £2.2M study funded by UK MRC to investigate how Klebsiella pneumoniae silently colonises the gut before causing deadly infections. 🔬🦠 Read more 👉 bit.ly/4mNSreh
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