Kondo, Notbohm, et al. show that the BRAF N-terminal acidic motif engages the dimeric interface to drive an asymmetric arrangement in which only one protomer adopts a canonical active kinase conformation. Captured MEK1 Ser222 phosphorylation and mutational analysis corroborate that this motif is required for full BRAF kinase activity.

Just over a year ago, I wrote about the “chainsaw massacre” being perpetrated by Elon Musk and his acolytes at DOGE. At the time, these were the most visible elements – the most visible outrages – …

The University of Zurich is the largest university in Switzerland and one of the most prominent in Europe. For research purposes the Biovision Center and Flow Cytometry Facility offer services to supp...

Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter enzymes (kinases) and phosphoeraser enzymes (phosphata...

Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track)

Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track)

Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organis...

David Morens, 78, was stripped and handcuffed for email violations

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?