Head direction (HD) cells are required for spatial orientation. Protocols that combine functional identification with anatomical recovery of single HD neurons remain technically demanding. We present ...

This conference will bring together leading experts to discuss how neuromodulatory systems shape neuronal circuit dynamics, behavior, and computation. The program will focus on how neuromodulators suc...

Aversive experiences and antidepressant treatment stimulate neuron production in the adult septum.

Previous work has demonstrated that repeated presentations of a conditional stimulus (CS) with a weak shock following training with a strong shock can reduce later conditional responding to that CS. W...

The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and a...

Nature Neuroscience - Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories...

Modern high-density neural recordings demand spike sorting algorithms that can handle diverse probe geometries and complex, neuron-specific drift, yet existing methods often rely on rigid geometric as...

Learning systems must constantly decide whether to create new representations or update existing ones. For example, a child learning that a bat is a mammal and not a bird would be best served by creat...

Tosoni and colleagues identify immature neurons in the aged human hippocampus with signatures of younger biological age and cellular fitness. Their molecular programs and intercellular interactions ar...

Tosoni and colleagues identify immature neurons in the aged human hippocampus with signatures of younger biological age and cellular fitness. Their molecular programs and intercellular interactions ar...

Post-doctoral positions are available in the Sensory and Behavioural Neuroscience Unit (https://www.oist.jp/research/research-units/sbn) at Okinawa Institute of Science and Technology Graduate Univers...

Hainmueller, Heynold, et al. studied the activity and synaptic interactions of different excitatory and inhibitory neuron types in the dentate gyrus of freely behaving mice. Bidirectional optogenetic manipulations revealed roles for interneurons in selecting cell assemblies through winner-take-all dynamics that go beyond simple circuit suppression.

Zipple et al. show that transferring laboratory mice to naturalistic outdoor enclosures prevents and even reverses a canonical anxiety phenotype in rodents. The findings underscore the value of studyi...

Light: Science & Applications - ULTRA, an ultra-large-FOV two-photon microscope enabling cellular-resolution imaging across 50 mm² and 900 μm depth, facilitating comprehensive,...

Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Spatial learning depends on the rapid formation of hippocampal CA1 place cell representations through behavioral timescale synaptic plasticity (BTSP)[1][1]–[7][2]. BTSP is driven by dendritic Ca²⁺ pla...

Cell assemblies have been proposed as key units of brain activity, underlying diverse functions, but their basic features are not well understood. This study shows that interactions between cell assem...

To identify fundamental neuroscientific principles that generalize across species, neuroscientists must frame their research through an evolutionary lens.

Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...