Tosoni and colleagues identify immature neurons in the aged human hippocampus with signatures of younger biological age and cellular fitness. Their molecular programs and intercellular interactions ar...

Kempermann and colleagues discuss new directions in neuroscience stemming from an understanding that adult neurogenesis contributes to brain function in health and disease. They discuss the role and function of adult stem cells; the impact of environmental regulation; the interplay between development, plasticity, and aging; and other fundamental questions.

Huntington’s disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. W…

Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...

The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have high...

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...

Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...

Tosoni et al. probe the challenges related to the design, analysis, and interpretation of single-cell transcriptomic studies in the adult human hippocampal neurogenic niche and propose a series of cri...