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GenomeTDCC

@genometdcc.org

504 followers 482 following 134 posts

Technology Development Coordinating Center at NHGRI. Advancing innovation in genomic technology development through collaboration, promoting standards, and outreach in conjunction with The Jackson Laboratory 🧬💻🧪

Posts Replies Media

Reposted by GenomeTDCC

Luca Pinello @lucapinello.bsky.social · 14/08/2026

Last call! Tomorrow, Aug 14, is the deadline for NECB 2026 abstracts. Want to present a poster or selected talk this October at Microsoft Research New England? Submit now at newenglandcompbio.org. I hope you can join us! #NECB2026 #ComputationalBiology #Bioinformatics

newenglandcompbio.org

NECB 2026 — New England Computational Biology Symposium

New England Computational Biology Symposium 2026 — Oct 1–2, Cambridge, MA

Reposted by GenomeTDCC

Sudarshan Pinglay @sudpinglay.bsky.social · 04/06/2026

How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.6... nature.com/articles/d41...

Why a synthetic human genome is still worth building

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

GenomeTDCC @genometdcc.org · 22/05/2026

🧪 Pre-print alert! NanoCortex: A Unified Agentic System for Nanopore Sequencing Analysis A new end-to-end framework to bridge the gap between nanopore seq data and biological discovery. @srouhanifard.bsky.social, @wanunupore.bsky.social Read the full pre-print 👇 www.biorxiv.org/content/10.6... 🧬💻👩‍🔬

Overview of NanoCortex Agentic System.
https://www.biorxiv.org/content/10.64898/2026.05.19.726254v1/

GenomeTDCC @genometdcc.org · 15/05/2026

🧪🧬💻 #STS

GenomeTDCC @genometdcc.org · 12/05/2026

What if RNA sequencing didn’t need cDNA, references, or assumptions? 🧪🧬💻 DirectSeq Biosciences is redefining the field with mass spec–based, direct RNA sequencing and a bold goal: mapping the entire Human RNome. 170+ RNA modifications. One new approach. 🎥 Watch how it works: youtu.be/xtYW8YjfvwY

Revolutionizing RNA Sequencing: Inside DirectSeq Biosciences’ Breakthrough Technology

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 08/05/2026

RNA does more than transmit information. It shapes the nucleus itself. 🧪🧬💻 @mitchguttman.bsky.social shows how non-coding RNAs form spatial compartments that organize proteins, regulate gene expression, and influence RNA processing. youtu.be/WBw7Rdb1HUU

RNA Promotes the Formation of Spatial Compartments Throughout the Nucleus

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 08/05/2026

Introducing LaSS and GLaSS - Wenyi Feng reveals how loss of FMRP in Fragile X Syndrome leads to widespread R-loop accumulation and DNA damage, and introduces new tools to map these structures with precision. A new perspective on how genome regulation connects to disease. youtu.be/ryrOhKkLA50 🧪💻🧬👩‍🔬

Linking Cytosolic Single-Stranded DNA Formation to Fragile X Syndrome Pathology

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 08/05/2026

Martha Bulyk presents new insights into transcription factor binding and gene regulation. 🧪💻🧬👩‍🔬 youtu.be/Oc6Nt8x_snk Innovative methods PADIT-seq and PIONEAR-seq reveal how overlapping binding sites and chromatin context shape transcription factor activity beyond traditional DNA motifs

PADIT-seq and PIONEAR-seq: New Insights into Transcription Factor Binding

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 06/05/2026

Spatial genomics is entering the era of scale. Roy Wollman introduces ATLAS, a scalable approach to spatial transcriptomics that turns massive tissue datasets into actionable insight. 🧪💻🧬 youtu.be/0o9XCh1pOII #SpatialTranscriptomics #SystemsBiology #Genomics

Why Counting Molecules is Failing Spatial Biology (And How to Fix It)

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 06/05/2026

Fei Chen showcases Slide-tags, a powerful approach that maps gene expression while preserving where cells live and interact in real tissue. From brain architecture to tumor ecosystems, spatial biology is revealing how cellular neighborhoods shape function and disease. 🧪🧬💻🔬 youtu.be/-lU4ODTLGZU

Space the Final Frontier: Genomics in the Tissue Context

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 06/05/2026

Recording cell lineage at scale is transforming developmental biology. @jshendure.bsky.social highlights how DNA "Typewriter" enables genome-encoded lineage tracking, and how monoclonal gastruloids reveal how early cell states influence fate decisions. youtu.be/TlDZtjFL3F8 🧪💻🧬

Lineage Recording and Barcoding of Monoclonal Models of Early Development

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 06/05/2026

Epigenetic memory shapes how cells respond to the future. jbuenrostro.bsky.social highlights how single-cell ATAC-seq and computational models reveal lasting effects of environmental signals on gene regulation. youtu.be/w3l2jhlTaYA 🧪🧬💻

Epigenomics: Recording the Past and Predicting the Future

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 02/04/2026

Final session of the Genome Technology Development Webinar Series APRIL 7 @ 1PM ET register: www.jax.org/genometechdev26 This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms. 🧪💻🧬👩‍🔬 Supported by NHGRI and @jax.org

Upcoming Webinar: Exploring How Genome Organization Shapes Biological Function
Free registration: www.jax.org/genometechdev26
Join us for an exciting webinar bringing together leading researchers who are uncovering new layers of genome regulation and nuclear organization.

Featured Speakers & Talks:
Martha Bulyk – Revealing additional layers of cis‑regulatory codes governing transcription factor interactions
Wenyi Feng – Linking cytoplasmic single‑stranded DNA detection to Fragile X Syndrome pathology
Mitchell Guttman – RNA promotes the formation of spatial compartments throughout the nucleus

This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms.

GenomeTDCC @genometdcc.org · 31/03/2026

There's still time to register for today's webinar at 2PM EDT. 👉www.jax.org/genometechdev26👈 Charting Cellular Futures: Lineage Recording and Regulatory Network Insights. 🧪💻🧬 Speakers: @jshendure.bsky.social and @jbuenrostro.bsky.social

2026 Genome Technologies Development Series - The Jackson Laboratory

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Reposted by GenomeTDCC

The Jackson Laboratory @jax.org · 26/03/2026

Huge congratulations to Mark Adams, professor and interim scientific director at The Jackson Laboratory for Genomic Medicine, who has been elected a 2025 Fellow of @aaas.org — one of the most distinguished lifetime honors for scientists. 🎉 🧪

Mark Adams honored as 2025 AAAS Fellow for his contributions to genomics

At The Jackson Laboratory, Adams’ leadership in genomics builds on a career of pioneering work in DNA sequencing and genome mapping that has helped lay the foundation for modern precision medicine

GenomeTDCC @genometdcc.org · 25/03/2026

Wonder how to directly connect live-cell behavior with the molecular states driving it? Magali Soumillon, Co-Founder & CEO of Flexomics, introduces a single-cell platform that merges live-cell imaging with sequencing from the same cells. 🧪💻🧬👩‍🔬 youtu.be/RH8WBbZMXIQ

Flexomics: Advancing Single-Cell Biology with Integrated Imaging and Sequencing

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 24/03/2026

Congratulations Xin Jin! 🧪👩‍🔬🧬💻

GenomeTDCC @genometdcc.org · 24/03/2026

The Genome Technology Development Webinar Series. 👉 www.jax.org/GenomeTechDev26 👈 Three webinars featuring leading scientists discussing current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Roundtable discussion following the presentations 🧪🧬💻👩‍🔬 #edusky

GenomeTDCC @genometdcc.org · 19/03/2026

Have you registered for the Genome Technologies Development Webinar Series?? 🧪🧬💻👩‍🔬 www.jax.org/GenomeTechDev26 Each session includes scientific presentations and a roundtable discussion examining current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

The TDCC in conjunction with NHGRI and The Jackson Laboratory invite you to the free Genome Technologies Development Webinar Series. Registration: www.jax.org/GenomeTechDev26
Rapid advances in genomic analysis have increased the efficiency, accuracy, and depth of biological discovery, and these improvements are driven by innovative approaches in spatial profiling, single-cell genomics, functional genomics, and genome organization.
This series brings together experts whose research continues to expand the frontiers of genome technology. The sessions are designed for postsecondary students, postdoctoral fellows, and biomedical researchers who are seeking a deeper understanding of how emerging tools are developed, applied, and refined. Each event includes scientific presentations and a roundtable discussion that examines current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

Revealing Biological Complexity Through Spatial Profiling
26, MARCH 3:00 – 4:00 PM ET

Speakers:
Fei Chen, Ph.D.
Roy Wollman, Ph.D.
Moderator: Ramalakshmi Ramasamy, Ph.D.

Charting Cellular Futures: Lineage Recording and Regulatory Network Insights
31, MARCH 2:00 – 3:00 PM ET

Speakers:
Jay Shendure MD, Ph.D.
Jason Buenrostro, Ph.D.
Moderator: Yashwanth Ashok, Ph.D.

Exploring How Genome Organization Shapes Biological Function
7, APRIL 1:00 – 2:00 PM ET

Speakers:
Martha Bulyk, Ph.D.
Wenyi Feng, Ph.D.
Mitch Guttman, Ph.D.
Moderator: Inés Patop, Ph.D.

GenomeTDCC @genometdcc.org · 18/03/2026

You're invited to the webinar session: Exploring How Genome Organization Shapes Biological Function Featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman. 🧪🧬💻👩‍🔬 Free Registration: www.jax.org/genometechdev26 📅 April 7, 1:00 PM - 2:00 PM ET

Exploring How Genome Organization Shapes Biological Function
A webinar featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman.
Registration: www.jax.org/genometechdev26
April 7, 1:00 PM - 2:00 PM ET

GenomeTDCC @genometdcc.org · 17/03/2026

🧪🧬💻👩‍🔬

GenomeTDCC @genometdcc.org · 17/03/2026

Coming Soon: March 31 @2pm ET. 📅 Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. Free webinar featuring @jshendure.bsky.social and @jbuenrostro.bsky.social. Register www.jax.org/GenomeTechDev26/ 🧪🧪💻

Free webinar featuring Jay Shendure and Jason Buenrostro. Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. March 31 2pm ET. Register www.jax.org/GenomeTechDev26/

GenomeTDCC @genometdcc.org · 12/03/2026

Genomic technologies are quickly advancing! Check out our webinar series featuring leading innovators. 🧪🧬💻 Register once for 3 Webinars: www.jax.org/genometechde... Speakers: Fei Chen Roy Wollman Martha Bulyk @mitchguttman.bsky.social Wenyi Feng @jshendure.bsky.social @jbuenrostro.bsky.social

TDCC is hosting a webinar series featuring leading innovators. Free registration at www.jax.org/GenomeTechDev26

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GenomeTDCC @genometdcc.org · 11/03/2026

You're invited to the webinar "Revealing Biological Complexity Through Spatial Profiling", featuring Roy Wollman and Fei Chen. Session moderator: Ramalakshmi Ramasamy March 26, 3 - 4 PM ET Free Registeration: www.jax.org/genometechde... Presented with support by @jaxeducation.bsky.social 🧪🧬💻

Revealing Biological Complexity Through Spatial Profiling webinar. Featuring Roy Wollman and Fei Chen. March 26 at 3 PM ET.

Reposted by GenomeTDCC

EpiCypher @epicypher.bsky.social · 20/01/2026

Genomics & single-cell researchers—expand your toolkit. 👨‍🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies. Register Here: 👉 app.livestorm.co/epicypher/single-c…

GenomeTDCC @genometdcc.org · 13/11/2025

Captify: A new platform to study chromatin readers in the nucleosome context 🧪💻🧬 Recently published in Nucleic Acids Research @narjournal.bsky.social, the folks at @epicypher.bsky.social discuss development & integration of these easily adoptable biochemical and genomic tools doi.org/10.1093/nar/...

Nucleosome context regulates chromatin reader preference

Abstract. Chromatin is more than a simple genome packaging system but rather locally distinguished by histone post-translational modifications (PTMs) that

GenomeTDCC @genometdcc.org · 13/11/2025

🧪🧬💻 Congratulations on the recent publication from @jshendure.bsky.social, @troymcdiarmid.bsky.social, @uwgenome.bsky.social and colleagues! 👇 www.nature.com/articles/s41...

Reposted by GenomeTDCC

Jay Shendure @jshendure.bsky.social · 14/10/2025

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...

GenomeTDCC @genometdcc.org · 01/10/2025

New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 18/09/2025

New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩‍🔬 www.youtube.com/watch?v=gOta... Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation. Recently published in @natsmb.nature.com

DNA Bendability Regulates Transcription Factor Binding to Nucleosomes (PIONEAR-seq)

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 08/09/2025

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬 Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing! It's all there on the GenomeTDCC YouTube channel! www.youtube.com/playlist?lis...

Reposted by GenomeTDCC

Nature Biotechnology @natbiotech.nature.com · 05/09/2025

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41... rdcu.be/eyzXy

Non-profits wade in where for-profit life science investment fears to tread - Nature Biotechnology

For decades, and in the exceptional instance of the Institut Pasteur for over a century, non-profit organizations have augmented R&D to advance scientific understanding and develop affordable and ...

GenomeTDCC @genometdcc.org · 03/09/2025

Martha Bulyk & Shubham Khetan just dropped a @nature.com paper redefining how we think about transcription factor binding, noncoding variants, and disease. PADIT-seq, reveals that multiple overlapping binding sites drive TF occupancy and gene expression 🧪🧬💻👩‍🔬 Highlight 📽️https://youtu.be/45hdZ6R9fX4

PADIT-seq: Protein affinity to DNA by in vitro transcription and RNA sequencing

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 29/08/2025

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GenomeTDCC @genometdcc.org · 27/08/2025

What if doing something poorly could lead to something great? Rob Mitra, @washugenetics.bsky.social, dives into the evolution of genome tech, short-read sequencing, and how his lab is fighting rising drug costs with innovation. 🧪🧬💻 #STS 📺 Watch the keynote: youtu.be/C8U5WDA9ri4 #genomics #Biotech

Technology Development for Genome Analysis - Rob Mitra, PhD

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 25/08/2025

What if DNA didn’t use ACGT, but had PZSB instead? UW and FfAME researchers describe how they were able to sequence a synthetic DNA molecule made from 4 artificial bases in @natcomms.nature.com 🧪🧬🖥️ Check out the publication highlight on “ALIEN DNA” 👇 www.youtube.com/watch?v=S6tE...

Sequencing a DNA analog composed of artificial bases

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 22/08/2025

RNA isn’t just a messenger. It’s a modified masterpiece! 🧪 Over 10,000 sites in mRNA are chemically tagged, and we’re only beginning to understand why. Kristin Koutmou @umich.edu explores the tools that reveal this hidden layer of gene regulation. Must-watch! 🎥👇 www.youtube.com/watch?v=s5Bt... 👩‍🔬🧬🖥️

Peeking Behind the Curtain: Technologies to Unveil RNA Modification Landscape - Kristin Koutmou, PhD

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 21/08/2025

DNA beyond ACGT? But how do you sequence? 🧬 🖥️ youtu.be/GN6_Hc9tYow Andrew Laszlo explains how #nanopore sequencing reads modified and synthetic bases like Z, P, B, and S by measuring ion current shifts instead of chemical pairing. This technology could reshape synthetic biology and epigenetics. 🧪

Nanopore Sequencing Beyond ACGT - Andrew Laszlo, PhD

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 20/08/2025

Winston Timp @timp0.bsky.social explains how single-molecule seq is transforming our understanding of gene regulation and epigenetic complexity 🧪🖥️🧬 www.youtube.com/watch?v=fj1_... Direct detection of 5mC and 5hmC, supports cell-type deconvolution, and reveals tissue-specific regulatory features

Decoding the Centra Dogma with Single Molecule Sequencing - Winston Timp, Ph.D.

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 13/08/2025

DNA has become programmable. 🧬🖥️ Sasha Levy (BacStitch DNA) discusses how #DNA engineering has evolved from basic cut-and-paste to programmable systems. Learn how enzymatic synthesis and in vivo assembly are shaping the future of synthetic biology 🧪 #STS youtu.be/kSAm-2FbNus

From Typewriters to Code Editors: The History and Future of DNA Writing Tools - Sasha Levy, PhD

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 08/08/2025

Jingyi Jessica Li @jsb-ucla.bsky.social (@fredhutch.bsky.social) (formerly @ UCLA) explains how statistics can make genomics more reliable From RNAseq to single-cell data, she shows how permutation testing reveals flaws in popular methods and can help make better decisions 🧪🖥️🧬👩‍🔬 youtu.be/t2pxOsJ9mgE

Making Genomics More Reliable with Statistics - Jingyi Jessica Li, PhD

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 07/08/2025

Not that kind of Alien!👽 De novo #nanopore sequencing of ALIEN (ALternative Isoinformational ENgineered) #DNA. Direct, label-free, single-molecule sequencing. @natcomms.nature.com www.nature.com/articles/s41... Funded in part by an NHGRI Opportunity Fund (genometdcc.org/opportunity-...) 🧪🧬🖥️ #STS

Sequencing a DNA analog composed of artificial bases - Nature Communications

The ability to sequence oligonucleotides which consist entirely of artificial bases will facilitate their ongoing development and use. Here authors demonstrate de novo nanopore sequencing of DNA oligo...

GenomeTDCC @genometdcc.org · 05/08/2025

RNA is never naked 🧪🖥️🧬 Gene Yeo @ucsandiego.bsky.social reveals how RNA-binding proteins (RBPs) shape gene expression, drive disease, and can unlock new therapies. From splicing to synthetic RBPs, this talk is packed with insights youtu.be/AnhbGp-pA-w #RNA #AcademicSky @sanfordstemcell.bsky.social

RNAs are not naked - Gene Yeo, PhD, MBA

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 04/08/2025

📢Job Opening! 🧪🖥️🧬👩‍🔬 Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing. Dr. Ya-Ming Hou at Thomas Jefferson University houlaboratory.com/research #HigherEd #EDUSky #AcademicSky #STS

GenomeTDCC @genometdcc.org · 01/08/2025

Happy #RNADay! What happens to RNA after transcription? @stirlingchurchman.bsky.social tracks RNA flow through the cell, revealing key insights into gene regulation, nuclear degradation & RNA kinetics. A fascinating look into #RNA biology! 🧪🧬🖥️👩‍🔬 youtu.be/XAKMASk_fc4

The Many Lives of mRNA

YouTube video by GenomeTDCC

GenomeTDCC @genometdcc.org · 31/07/2025

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GenomeTDCC @genometdcc.org · 30/07/2025

How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...

A Brief History of Contemporary 3D Genomics Technologies

YouTube video by GenomeTDCC

Reposted by GenomeTDCC

Mitch Guttman @mitchguttman.bsky.social · 26/07/2025

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

GenomeTDCC @genometdcc.org · 28/05/2025

📅 June 9 - Genomic Technologies Open Science Day at @washu.bsky.social and online www.jax.org/scienceday25 Register for Free by: May 30: In-Person June 8: Virtual Learn how emerging tech is used to manipulate RNA & DNA, study genome function and structure, and navigate multi-omic analysis 🧪👩‍🔬🧬🖥️

Genomic Technologies Open Science Day on June 9. The event will be held at the Eric. P. Newman Education Center at Washington University in St. Louis and broadcast live online. Registration is free at https://www.jax.org/scienceday25/

Reposted by GenomeTDCC

JAX Genomic Education @jaxeducation.bsky.social · 09/05/2025

🔬 Excited about the future of genomic tech? Join NHGRI & @genometdcc.bsky.social's hybrid forum to explore how new tools and technologies are used, as well as the potential opportunities and challenges ahead. 📅 Open to grad students, postdocs & researchers! Register: www.jax.org/education-an...

Light blue graphic with dark blue text reads, "June 9, 2025 | Washington University, St. Louis, MO & Virtual | Genomic Technologies Open Science Day" with logos for The Jackson Laboratory, Genome TDCC and the National Human Genome Institute.