iiinova — where your digital self keeps evolving

GenomeTDCC @genometdcc.org · 22/05/2026

🧪 Pre-print alert! NanoCortex: A Unified Agentic System for Nanopore Sequencing Analysis A new end-to-end framework to bridge the gap between nanopore seq data and biological discovery. @srouhanifard.bsky.social, @wanunupore.bsky.social Read the full pre-print 👇 www.biorxiv.org/content/10.6... 🧬💻👩‍🔬

Overview of NanoCortex Agentic System.
https://www.biorxiv.org/content/10.64898/2026.05.19.726254v1/

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GenomeTDCC @genometdcc.org · 02/04/2026

Final session of the Genome Technology Development Webinar Series APRIL 7 @ 1PM ET register: www.jax.org/genometechdev26 This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms. 🧪💻🧬👩‍🔬 Supported by NHGRI and @jax.org

Upcoming Webinar: Exploring How Genome Organization Shapes Biological Function
Free registration: www.jax.org/genometechdev26
Join us for an exciting webinar bringing together leading researchers who are uncovering new layers of genome regulation and nuclear organization.

Featured Speakers & Talks:
Martha Bulyk – Revealing additional layers of cis‑regulatory codes governing transcription factor interactions
Wenyi Feng – Linking cytoplasmic single‑stranded DNA detection to Fragile X Syndrome pathology
Mitchell Guttman – RNA promotes the formation of spatial compartments throughout the nucleus

This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms.

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GenomeTDCC @genometdcc.org · 24/03/2026

The Genome Technology Development Webinar Series. 👉 www.jax.org/GenomeTechDev26 👈 Three webinars featuring leading scientists discussing current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Roundtable discussion following the presentations 🧪🧬💻👩‍🔬 #edusky

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GenomeTDCC @genometdcc.org · 19/03/2026

Have you registered for the Genome Technologies Development Webinar Series?? 🧪🧬💻👩‍🔬 www.jax.org/GenomeTechDev26 Each session includes scientific presentations and a roundtable discussion examining current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

The TDCC in conjunction with NHGRI and The Jackson Laboratory invite you to the free Genome Technologies Development Webinar Series. Registration: www.jax.org/GenomeTechDev26
Rapid advances in genomic analysis have increased the efficiency, accuracy, and depth of biological discovery, and these improvements are driven by innovative approaches in spatial profiling, single-cell genomics, functional genomics, and genome organization.
This series brings together experts whose research continues to expand the frontiers of genome technology. The sessions are designed for postsecondary students, postdoctoral fellows, and biomedical researchers who are seeking a deeper understanding of how emerging tools are developed, applied, and refined. Each event includes scientific presentations and a roundtable discussion that examines current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

Revealing Biological Complexity Through Spatial Profiling
26, MARCH 3:00 – 4:00 PM ET

Speakers:
Fei Chen, Ph.D.
Roy Wollman, Ph.D.
Moderator: Ramalakshmi Ramasamy, Ph.D.

Charting Cellular Futures: Lineage Recording and Regulatory Network Insights
31, MARCH 2:00 – 3:00 PM ET

Speakers:
Jay Shendure MD, Ph.D.
Jason Buenrostro, Ph.D.
Moderator: Yashwanth Ashok, Ph.D.

Exploring How Genome Organization Shapes Biological Function
7, APRIL 1:00 – 2:00 PM ET

Speakers:
Martha Bulyk, Ph.D.
Wenyi Feng, Ph.D.
Mitch Guttman, Ph.D.
Moderator: Inés Patop, Ph.D.

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GenomeTDCC @genometdcc.org · 18/03/2026

You're invited to the webinar session: Exploring How Genome Organization Shapes Biological Function Featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman. 🧪🧬💻👩‍🔬 Free Registration: www.jax.org/genometechdev26 📅 April 7, 1:00 PM - 2:00 PM ET

Exploring How Genome Organization Shapes Biological Function
A webinar featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman.
Registration: www.jax.org/genometechdev26
April 7, 1:00 PM - 2:00 PM ET

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GenomeTDCC @genometdcc.org · 17/03/2026

Coming Soon: March 31 @2pm ET. 📅 Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. Free webinar featuring @jshendure.bsky.social and @jbuenrostro.bsky.social. Register www.jax.org/GenomeTechDev26/ 🧪🧪💻

Free webinar featuring Jay Shendure and Jason Buenrostro. Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. March 31 2pm ET. Register www.jax.org/GenomeTechDev26/

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GenomeTDCC @genometdcc.org · 12/03/2026

Genomic technologies are quickly advancing! Check out our webinar series featuring leading innovators. 🧪🧬💻 Register once for 3 Webinars: www.jax.org/genometechde... Speakers: Fei Chen Roy Wollman Martha Bulyk @mitchguttman.bsky.social Wenyi Feng @jshendure.bsky.social @jbuenrostro.bsky.social

TDCC is hosting a webinar series featuring leading innovators. Free registration at www.jax.org/GenomeTechDev26

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GenomeTDCC @genometdcc.org · 11/03/2026

You're invited to the webinar "Revealing Biological Complexity Through Spatial Profiling", featuring Roy Wollman and Fei Chen. Session moderator: Ramalakshmi Ramasamy March 26, 3 - 4 PM ET Free Registeration: www.jax.org/genometechde... Presented with support by @jaxeducation.bsky.social 🧪🧬💻

Revealing Biological Complexity Through Spatial Profiling webinar. Featuring Roy Wollman and Fei Chen. March 26 at 3 PM ET.

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GenomeTDCC @genometdcc.org · 08/09/2025

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬 Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing! It's all there on the GenomeTDCC YouTube channel! www.youtube.com/playlist?lis...

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GenomeTDCC @genometdcc.org · 04/08/2025

📢Job Opening! 🧪🖥️🧬👩‍🔬 Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing. Dr. Ya-Ming Hou at Thomas Jefferson University houlaboratory.com/research #HigherEd #EDUSky #AcademicSky #STS

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GenomeTDCC @genometdcc.org · 28/05/2025

📅 June 9 - Genomic Technologies Open Science Day at @washu.bsky.social and online www.jax.org/scienceday25 Register for Free by: May 30: In-Person June 8: Virtual Learn how emerging tech is used to manipulate RNA & DNA, study genome function and structure, and navigate multi-omic analysis 🧪👩‍🔬🧬🖥️

Genomic Technologies Open Science Day on June 9. The event will be held at the Eric. P. Newman Education Center at Washington University in St. Louis and broadcast live online. Registration is free at https://www.jax.org/scienceday25/

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GenomeTDCC @genometdcc.org · 25/04/2025

HAPPY DNA DAY! 🧬🧪 Genomics research has provided humanity with a transformative understand of life at the molecular level leading to a wide range of benefits in medical advancements, synthetic biology, biotechnology, infectious disease, agriculture, and evolution. We are connected by ATGC

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GenomeTDCC @genometdcc.org · 24/04/2025

From @nickingolia.bsky.social at @ucberkeleyofficial.bsky.social 🧪🧬🖥️ Disordered protein regions hold powerful sway over gene expression, as this new large-scale study reveals how they regulate mRNA stability and translation without a fixed structure. Published in @nature.com doi.org/10.1038/s415...

Schematic of the fluorescence-based tethering assay as described in the recently published Nature paper by Joseph Lobel and Nick Ingolia, "Deciphering disordered regions controling mRNA decay in high-throughput".

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GenomeTDCC @genometdcc.org · 23/04/2025

🚨PRE-PRINT 🧪🧬🖥️👩‍🔬 Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions From Barak Cohen's lab at @washu.bsky.social Read the pre-print 👇 doi.org/10.1101/2025... Learn more about the research from the Cohen lab: bclab.wustl.edu

From the BioRxiv pre-print article "Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions" by Yawei Wu et al.
Fig. 1. Design of long-range MPRA. a, Design of the enhancer landing pad and the promoter landing
pad. The enhancer landing pad contains a dual promoter driving expression of an mTagBFP fluorescent
protein and a thymidine kinase (TK) gene for counterselection, flanked by FRT and F3 sites for RMCE.
available under aCC-BY-NC 4.0 International license.
was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made
bioRxiv preprint doi: https://doi.org/10.1101/2025.04.21.649048; this version posted April 22, 2025. The copyright holder for this preprint (which
The promoter landing pad expresses the mEmerald fluorescent protein and iCaspase9 for
counterselection and is flanked by loxFAS and loxP sites for orthogonal RMCE. b-c, Workflow of
long-range MPRA. eBC: enhancer barcode; rBC: random barcode; dBC: distance barcode. A barcoded
enhancer library is integrated into pooled long-range landing pad cells through Flpase-facilitated
recombination. After counterselection with Ganciclovir, cells with successful integration are enriched.
Cells are sorted into different bins based on mScarlet fluorescence level. Genomic DNA is extracted from
each bin; barcodes are amplified and sequenced. Reporter gene expression of each enhancer at each
distance is calculated as the weighted average of fluorescence levels across bins.

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GenomeTDCC @genometdcc.org · 23/04/2025

📅 Genomic Technologies Open Science Day - June 9 FREE event featuring expert developers and users! Register: www.jax.org/scienceday25/ Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social 🧪🧬🖥️👩‍🔬 #STS Learn more at genometdcc.org#outreachevents

Free event with developers and users of genomic technologies. Register at https://www.jax.org/scienceday25/
The objective of this forum is to provide post-secondary students, postdoctoral associates/fellows and biomedical researchers with a fundamental understanding of how these new technologies are utilized, as well as emerging opportunities and challenges associated with their optimization and use.

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GenomeTDCC @genometdcc.org · 22/04/2025

Single Cell Genomics Day! 🧪🧬🖥️ Friday April 25 (10:00 AM to 5:00 PM EDT) Watch the event live satijalab.org/scgd25/ The Rahul Satija Lab at @nygenome.org and NYU is hosting the annual SINGLE-CELL GENOMICS DAY on #DNADay

Single Cell Genomics Day hosted by Rahul Satija. Happening on April 25, 2025

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GenomeTDCC @genometdcc.org · 11/04/2025

DYK www.youtube.com/@genometdcc has videos on the latest genomic technology being developed by researchers supported by NHGRI? 👩‍🔬 🧪🧬🖥️ #STS Highlighting new research pubs and #educational videos discussing innovations in synthetic biology, nucleic acid and protein seq, large-scale genomics, and more!

The Genome TDCC YouTube channel has several videos on the latest genomic technology being developed by researchers supported by NHGRI. Highlights on new research publications and educational videos discussing new developments from nucleic acid synthesis, protein sequencing, large-scale genomic analysis and more.

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GenomeTDCC @genometdcc.org · 28/03/2025

FREE VIRTUAL SYMPOSIUM Featuring experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. April 10 - 11 Register: tinyurl.com/43kkxvp7 Hosted by the Center for Genomic Information Encoded by RNA Nucleotide Modifications 🧬🧪🖥️ #STS #RNA

A two-day virtual symposium featuring global experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. Hosted by the NIH/NHGRI Center for Genomic Information Encoded by RNA Nucleotide Modifications

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GenomeTDCC @genometdcc.org · 14/03/2025

Celebrate Pi day by embracing creativity, curiosity, and innovation (and 🥧) Science, Technology, Engineering, and Mathematics make our world safer, united, and healthier. Explore the innovations being advanced from the NHGRI Genome Technology program at genometdcc.org 🧪🧬🖥️👩‍🔬 #STS

It's Pi Day! A time to honor the beauty of circles, the brilliance of 3.14159, and the joy of discovery. Let's celebrate with creativity, curiosity, and maybe even dessert.

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GenomeTDCC @genometdcc.org · 03/02/2025

Everyday we're shuffling ... the genome. Investigating hundreds to thousands of major structural variants throughout a mammalian genome with Genome-Shuffle-seq. From @jshendure.bsky.social et al. published in @science.org 👉 www.science.org/doi/full/10.... 🧪 🧬 🖥️ #genesky

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GenomeTDCC @genometdcc.org · 18/11/2024

We work w/ >90 NHGRI-funded investigators who are advancing the development of innovative #genomic technologies, nucleic acid #synthesis, and #sequencing technology development ( #RNA, #DNA, and #proteins ). 🧪🧬🖥️👩‍🔬 Fostering collaboration, innovation, and dissemination genometdcc.org

Breakdown of the funded categories and key terms within the Genome Technology program grant portfolio including Small Business Innovation Research grants (R43/R44) and R21, R01 grants across 18 small businesses and >40 different research institutes

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GenomeTDCC @genometdcc.org · 29/10/2024

Center for Genome Editing and Recording 🧬📼 Inaugural 5-day CRISPR training workshop for college-level instructors from HBCUs. Learn hands-on genome editing techniques to start new genome editing courses or incorporate into existing classes. 🧪👩‍🔬🖥️ Apply by Nov 30 👇 app.smartsheet.com/b/form/73546...

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GenomeTDCC @genometdcc.org · 28/10/2024

Kicking off the Annual CEGS meeting in La Jolla, CA. 🧪🧬🖥 👩‍🔬 #STS Thank you to our hosts from the Center for Admixture Science and Technology w/ support from NHGRI, @jacksonlab.bsky.social Learn more about the NHGRI-funded Centers of Excellence in Genomic Science at www.genome.gov/Funded-Progr...

Center of Excellence in Genomic Science annual meeting

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GenomeTDCC @genometdcc.org · 22/10/2024

Hi BlueSky! We work w/ NHGRI-funded investigators who are advancing the development of innovative genomic technologies, nucleic acid synthesis, and sequencing technology development (RNA/DNA and proteins). 🧪🧬🖥️👩‍🔬 Fostering collaboration, innovation, and dissemination genometdcc.org

Breakdown of the NHGRI Genome Technology program grants and research areas that participate in the Technology Development Coordinating Center (TDCC).

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GenomeTDCC @genometdcc.org · 25/09/2024

🧪🧬🖥️ 👩‍🔬 DYK @genometdcc.bsky.social collaborates with Genome Technology Developers, Innovators, and Expert Users? Our YouTube showcases their work in sequencing, synthbio, and genomic tech. Check out the latest 📽️👇 youtube.com/@genometdcc Supported by NHGRI in collaboration w @jacksonlab.bsky.social

The GenomeTDCC YouTube channel showcases videos from genomic technology developers, innovators, and expert users.

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GenomeTDCC @genometdcc.org · 07/05/2024

Funding Biomedical Innovations for Non-Academic Entrepreneurs Webinar 🧪🧬🖥️👩‍🔬 Hosted by @XLerateHealth in collaboration w/ @NIH on 📅Tues, May 14 2PM-4PM EDT Learn about SBIR/STTR funding and XLerateHealth's programs and resources. To register, please visit bit.ly/3xHjbYY

Tuesday (5/14) from 2:00 PM to 4:00 PM EDT, a panel of NIH small business program representatives will discuss SBIR and STTR funding. This webinar is hosted by XLerateHealth in collaboration with more than a dozen NIH Institutes and Centers, to learn more about how non-academic biomedical entrepreneurs can jump start their business and develop their technology through funding at the National Institutes of Health.
This event isn’t just for non-academic entrepreneurs – Discussion will include opportunities for non-academic entrepreneurs and academic innovators to collaborate on these federally funded initiatives.
Attendees will learn about SBIR/STTR and other non-dilutive funding opportunities and commercialization resources for NIH applicants and awardees, as well as XLerateHealth’s entrepreneurial-focused programs and resources to support your journey! Presentations will be followed by a moderated Q&A session.

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GenomeTDCC @genometdcc.org · 01/05/2024

Interested in learning more about Genome Technology development and use? 🧪🧬🖥️👩‍🔬#STS Join us with @jaxeducation.bsky.social on June 10 for a FREE forum jax.org/gtf2024 Hear from leading developers and users! Interactive Workshops with @epicypher and @AlidaBio Meet with NHGRI SBIR-funded companies!

Promotional poster of the Genome Technology Forum. Being held in-person and online on June 10, 2024 from 9:30 AM to 5:30 PM Eastern Time. Free registration at https://www.jax.org/gtf2024

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GenomeTDCC @genometdcc.org · 25/04/2024

Happy #DNADay! Today celebrates the discovery of DNA's double helix in 1953. Research and technology development in genomics continues to advance our understanding of who we are and the world around us. Learn more about the work supported by NHGRI at www.genometdcc.org 🧪👩‍🔬🧬🖥️

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GenomeTDCC @genometdcc.org · 17/04/2024

Join us for the Genome Technology Forum! FREE Registration (hybrid event) jax.org/gtf2024 Fantastic lineup of speakers, interactive workshops with @Epicypher and @AlidaBiosciences, and more! Mark your calendars 📅 June 10 🧪🧬🖥️👩‍⚕️#STS In partnership with NHGRI and @jacksonlab.bsky.social

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GenomeTDCC @genometdcc.org · 29/03/2024

Single Cell Genomics Day Today at 10AM ET All talks streamed on Youtube and satijalab.org/scgd 🧪🧬🖥️

Advertisement for Single Cell Genomics Day live stream

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GenomeTDCC @genometdcc.org · 31/01/2024

A PRINTER w/o an ink subscription! An experimental + comp analysis framework for RBP-RNA interaction studies 👇 www.nature.com/articles/s41... A collaborative effort between Gene Yeo, Rahul Kohli, and Alexis Komor. Funded in part by NHGRI Genome Tech Dev Opportunity Funds 🧪🧬🖥️#STS

A reporter system to assay RNA base editing activity of candidate RNA
base editors (rBEs). a Reporter mRNA bearing twelve MS2 bacteriophage stemloops (yellowbars) downstreamof a Super folder GFP coding sequence (sfGFP) and a chimera bearing an MS2 coat-protein (MCP, black) domain fused to a candidate rBE (brown). b Strategy to test candidate rBEs. Plasmids encoding the constructs in
a) are co-transfected into HEK293XT cells so that the MCP binds the MS2 stemloops in the reporter, and the rBE catalyzes RNA editing. After total RNA is isolated, targeted RNA sequencing is used to detect edits along the reporter sequence. (text from https://www.nature.com/articles/s41467-024-45009-4)

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GenomeTDCC @genometdcc.org · 04/01/2024

A look into how RNA binding proteins govern alternative pre-mRNA splicing by enhancing exon inclusion with this recent publication in Nature Biotechnology. A collaborative effort from Marko Jovanovic (Columbia University) and Gene Yeo (UC San Diego) 🧪🖥️🧬 Check it out! 👇 doi.org/10.1038/s415...

Development of tethered function assays for detecting direct induction of exon inclusion. a, Schematic of luciferase reporters used in the assays and resulting isoforms after cellular mRNA processing. b, Analysis workflow for calculating percent-spliced-in from luminescence measurements. c, Splicing gels of lucMAPT-30D splicing in response to co-transfection with MCP-fused positive and negative controls. d, Bar graph of lucMAPT-30D reporter readout as calculated from the workflow in b with the same conditions as c. e, Experimental workflow of tethering assays. The effects of recruiting 718 MCP-fused RBPs are tested in both reporter contexts.

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GenomeTDCC @genometdcc.org · 14/11/2023

Using whole-animal scRNAseq, Cole Trapnell, Michael Dorrity, and colleagues assess the role of proteostasis - maintenance of proper protein synthesis, folding, and degradation during zebrafish development at increased temperatures 🖥️🧬🧪🐟 doi.org/10.1016/j.ce...

Embryo-wide profiling of transcription, timing, and cell composition in zebrafish reveals processes that limit development robustness under increasing temperatures.

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GenomeTDCC @genometdcc.org · 27/10/2023

Why settle for 4-letter DNA when you can have 12-letter supernumerary DNA 💪🧬?! Jorge Marchand with UW and FfAME colleagues devised an enzymatic strategy to insert xenonucleic acid (XNA) into standard DNA sequences to be read on a commerical nanopore device 🧪#STS www.nature.com/articles/s41...

Structures of standard purine and pyrimidin nucleobases found in life and structures of mutually orthogonal synthetic xenonucleobases. Overview of construction of libraries and four nucleotide kmer models and observed current signals. Example traces overlaying observed mean signal (orange) with expected signal produced by XNA model (blue) or standard DNA model (gray) kmer model.

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GenomeTDCC @genometdcc.org · 27/10/2023

🚨Pre-Print Alert🚨 Barcoding plasmids in vitro for each sample adds cost and limits throughput. Sasha Levy, Gavin Sherlock, and colleagues develop the Bacterial Positioning System, an in vivo plasmid barcoding platform for ONT sequencing. ⏬💲 ⏫throughput www.biorxiv.org/content/10.1... 🧬🖥️🧪#STS

Workflow and cost analysis of the Bacterial Positioning System (BPS), and in vivo barcoding platform

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GenomeTDCC @genometdcc.org · 25/10/2023

🚨PRE-PRINT ALERT🚨 Single-molecule protein sequencing is the next frontier in sequencing technology Latest from Jeff Nivala and colleagues - reading 100s of amino acids and PTMs along protein strands AND re-read multiple times w/modified nanopore arrays. 👇 www.biorxiv.org/content/10.1... 🧪🧬🖥️ #STS

Schematic of cis-based unfoldase approach on the MinION platform.

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GenomeTDCC @genometdcc.org · 06/10/2023

Coming from Gene Yeo's lab at UCSD 🧬🖥️ 🧪#STS Introducing FLARE - a fast and flexible workflow that identifies significantly edited regions from #RNAseq data. The FLARE codebase is available at github.com/YeoLab/FLARE Read more in BMC Bioinformatics 👇 doi.org/10.1186/s128...

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GenomeTDCC @genometdcc.org · 06/10/2023

Zhipeng Lu's team at the University of Southern California has uncovered a large network of snoRNA-tRNA interactions that control cellular states of proliferation and differentiation. This discovery partially solves the longstanding orphan snoRNA problem. 🧪🧬💻 www.pnas.org/doi/epdf/10....

A snoRNA-tRNA modifcation network governs codon-biased cellular states. Published in PNAS

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GenomeTDCC @genometdcc.org · 27/09/2023

🚨POSTDOCTORAL FELLOWSHIPS AVAILABLE🚨 Are you interested in #RNA interactions and modification mechanisms in human disease? There are postdoc positions available in Dr. Zhipeng Lu's lab at USC. Learn more about the research at zhipenglulab.org 🧪 🧬💻👩‍🔬 #AcademicSky #STS

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GenomeTDCC @genometdcc.org · 19/09/2023

Unidirectional transport of native proteins through an engineered #nanopore! Giovanni Maglia and colleagues use fixed charges to engineer a strong electroosmotic flow to thread and stretch proteins across a nanopore. Out now in NatureBiotech doi.org/10.1038/s415... 🧪🧬🖥️

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GenomeTDCC @genometdcc.org · 11/09/2023

At the GenomeTDCC, we ❤️ collaborating with the NHGRI Genome Technology Program grantees. Check out the cutting edge work they are currently engaged in doing at genometdcc.org/chart 🧪

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