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Gautham SANKARA

@gauthamsankara.bsky.social
153 followers 337 following 9 posts

Scientist @ Institut Pasteur Mechanobiology ⚙️ + Cryo-ET 🧊 | Capturing battles 🛡️ between host & pathogen 🦠 | Science at intersection of physics 🔭 and life 🧬

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Reposted by Gautham SANKARA
Enninga Lab @enningalab.bsky.social · 18/09/2025
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
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Gautham SANKARA @gauthamsankara.bsky.social · 06/06/2025
The cell looks like Inkay Pokémon🔬 — yellow glowing arms, pink heart. Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr
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Reposted by Gautham SANKARA
Institut Pasteur | 130 years of biomedical research @pasteur.fr · 02/06/2025
🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social
pasteur.fr
The plague bacillus became less virulent, prolonging the duration of two major pandemics
Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of...
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Reposted by Gautham SANKARA
Broad Institute @broadinstitute.org · 29/05/2025
A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social
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NBC News @nbcnews.com · 30/05/2025
Harvard president receives standing ovation during commencement.
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Ed Boyden @eboyden3.bsky.social · 30/05/2025
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
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Cell - a Cell Press journal @cp-cell.bsky.social · 16/05/2025
The new issue is out! 👉 cell.com/cell/current On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops 📷credit: Andreas Brunner.
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Reposted by Gautham SANKARA
Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 13/05/2025
Cohabitation shifts gut bacteria to protect the liver: Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense www.cell.com/cell-host-mi...
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Reposted by Gautham SANKARA
Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 13/05/2025
Major depressive disorder is a complex condition that cannot be fully explained by any one single established biological or environmental pathway www.nature.com/articles/s41...
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Reposted by Gautham SANKARA
Science Magazine @science.org · 01/05/2025
This week in Science, researchers delve into the #mathematics that shapes growing rose petals. 🌹 Explore our latest issue—featuring a new print design: scim.ag/42DasUT
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Reposted by Gautham SANKARA
PLOS Biology @plosbiology.org · 02/05/2025
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.
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Gautham SANKARA @gauthamsankara.bsky.social · 02/05/2025
Watching fission yeast divide is cool🦠. But showing it with a kymograph? Even cooler 😎, shows it all—mitosis, cell wall—packed into spatiotemporal magic🪄. Flattening time into 2D just makes it easier to understand. #FluorescenceFriday @pasteur.fr @pasteuredu.bsky.social #Microscopy #Microbiology🔬
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Gautham SANKARA @gauthamsankara.bsky.social · 28/04/2025
When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife
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Reposted by Gautham SANKARA
Cell - a Cell Press journal @cp-cell.bsky.social · 21/04/2025
Now online! Tissue geometry spatiotemporally drives bacterial infections
dlvr.it
Tissue geometry spatiotemporally drives bacterial infections
Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.
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Reposted by Gautham SANKARA
Nature @nature.com · 24/04/2025
An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations www.nature.com/articles/d41...
nature.com
Shapeshifting origami material shrinks when twisted
An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations.
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Reposted by Gautham SANKARA
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 23/04/2025
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
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Reposted by Gautham SANKARA
Jesse Veenvliet @jesseveenvliet.bsky.social · 19/04/2025
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
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Reposted by Gautham SANKARA
Benoit Ladoux @bladoux.bsky.social · 19/04/2025
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org Great work of Y. Shen, J. O'Byrne and @andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez! | PNAS www.pnas.org/doi/10.1073/...
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Gautham SANKARA @gauthamsankara.bsky.social · 04/04/2025
Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social
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Gautham SANKARA @gauthamsankara.bsky.social · 21/03/2025
Wrapping up two weeks of Principles and Applications of Fluorescence Microscopy #PAFM at @pasteur.fr Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy
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Gautham SANKARA @gauthamsankara.bsky.social · 07/03/2025
Sunny days in Paris, and this cell’s matching the vibe 🌞 Focal adhesions flaring up rocket TIRF 🚀 #FluorescenceFriday @pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
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Gautham SANKARA @gauthamsankara.bsky.social · 28/02/2025
Cells in motion remains in motion😇 #FluorescenceFriday @pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
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Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 19/02/2025
Our methods paper made it to bioRxiv: doi.org/10.1101/2025... Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5 #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM
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