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Jason Luke, MD, FACP, FASCO

@jasonlukemd.bsky.social
308 followers 177 following 15 posts

Physician-Scientist-Executive; Chief Medical Officer

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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 12/09/2025
Appreciate the profile www.statnews.com/pharmalot/20... from Ed Silverman & @statnews.com! Amazing progress at Strand Therapeutics advancing field leading genetic medicines. Check my quote on being a nutating mixer if I were a piece of lab equipment ;) #synbio #immunotherapy #cancerresearch
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Reposted by Jason Luke, MD, FACP, FASCO
Nature @nature.com · 27/07/2025
Nature research paper: Humoral determinants of checkpoint immunotherapy go.nature.com/41a8fin
go.nature.com
Humoral determinants of checkpoint immunotherapy - Nature
Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 28/06/2025
Podcast alert! Enjoyed discussing #ASCO25 #Immunotherapy & #Melanoma data w Dr. Diwakar Davar. Important studies that are advancing the field! @ascocancer.bsky.social dailynews.ascopubs.org/do/podcast-i...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 01/06/2025
The CheckPoints are ready to party - join us tonight Sunday June 1 at Buddy Guys! Best party of #ASCO25 & all for the great cause of the @sitcancer.bsky.social Forward Fund that supports post-doc & trainee awards. See you tonight!!!
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 27/04/2025
Time for the #AACR25 Annual Reception, featuring the #Checkpoints! Be there tonight 830 PM at McCormick Place West (Level 3) in the Skyline Ballroom (W375). We have a bunch of new tunes & rehearsal was great! @theaacr.bsky.social
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 23/04/2025
Excited to help lead Phase 2/3 frontline metastatic #melanoma TeLuRide-006 study of pembro +/- novel IV TLR7/8 agonist EIK1001. Super interesting pre-clinical & prelim responses in PD1 refractory dz. Trial is open in #Pittsburgh & globally for accrual! clinicaltrials.gov/study/NCT066...
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Reposted by Jason Luke, MD, FACP, FASCO
Society for Immunotherapy of Cancer @sitcancer.bsky.social · 18/04/2025
VIP tickets are available now! The CheckPoints will be back in Chicago on June 1 at Buddy Guy’s Legends. Donations will support SITC’s Forward Fund and benefit the next generation of cancer immunotherapy experts. LEARN MORE: www.sitcancer.org/funding/the-... #RockinForACure
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 14/04/2025
Talking IMA203 & SUPRAME trial #iwCART25 in Miami last wknd. Pass the word to #melanoma patients needing novel therapeutics. After ICI, this therapy has possibility for long-term dz control! Trial opening in USA & Europe. 1st pt got IMA203 in Pittsburgh last week! clinicaltrials.gov/study/NCT067...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 09/04/2025
Extremely excited re: IMA203 - PRAME TCR T cells Ph 1 study published in @natmedicine.bsky.social! This is a transformative Rx in #melanoma for HLA-A201+ & PD1 refractory pts. Compared to TIL, easier to make, less toxic & so far ~2x response rate in heavily pre-Rx. www.nature.com/articles/s41...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 24/03/2025
A @sitcancer.bsky.social vision statement on accelerating #clinicaltrials to get 100 immunotherapy regulatory approvals in 10 years. Excited to be part of this effort for the paper, for our field but most importantly for the people with #cancer we are working to #cure! jitc.bmj.com/content/13/3...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 18/03/2025
Tx @theaacr.bsky.social for highlighting our SITC #Checkpoints performance rocking the #AACR25 annual reception in Chicago - Sunday, April 27. The best #cancer science & the best party! Hope everyone will be there! @patrickhwumd.bsky.social @ferranprat.bsky.social www.aacr.org/blog/2025/03...
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Reposted by Jason Luke, MD, FACP, FASCO
Paul Rennert @pdrworld.bsky.social · 13/03/2025
and we provide some broader #biotech #bioblue context www.sugarconebiotech.com/insights/pd1...
sugarconebiotech.com
PD1 x VEGF bispecific landscape: examining Hope versus Hype. — SugarCone Biotech
There were waves of interest in this therapeutic space at ASCO in June 2024 and around the JP Morgan healthcare conference in January 2025. Here we take a look at the hope and the hype behind the PD1/...
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Reposted by Jason Luke, MD, FACP, FASCO
Nature @nature.com · 13/03/2025
Nature research paper: Spatial immune scoring system predicts hepatocellular carcinoma recurrence go.nature.com/3Dr0HiQ
go.nature.com
Spatial immune scoring system predicts hepatocellular carcinoma recurrence - Nature
A publicly accessible tool—the TIMES score—for predicting the risk of recurrence of hepatocellular carcinoma is revealed, providing mechanistic insights into the prognostic patterns for hepatocellular carcinoma.
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 13/03/2025
Amazing @sitcancer.bsky.social Spring Scientific on cell therapy in solid tumors! Appreciated op to discuss IMA203. One of the hottest agents in #melanoma & perhaps all of solid tumor oncology! Very excited that the SUPRAME Ph 3 study is now accruing pts! clinicaltrials.gov/study/NCT067...
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Reposted by Jason Luke, MD, FACP, FASCO
Society for Immunotherapy of Cancer @sitcancer.bsky.social · 27/02/2025
New Journal for ImmunoTherapy of Cancer ( #JITC ) short report: Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors bit.ly/43bFMuy @jasonlukemd.bsky.social @news.upmc.com @djpinato.bsky.social #OncSky #CanSky #research
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 14/02/2025
Enjoyed discussing LAG3 targeting #melanoma w @drbetofmdphd.bsky.social Major role for relatlimab while fianlimab data look as good/better so far! Field has been waiting long time for RELA-098 but Ph3 studies abound for cemi-fian metastatic, adjuvant and peri-op! www.medscape.org/viewarticle/...
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Reposted by Jason Luke, MD, FACP, FASCO
Nature Biotechnology @natbiotech.nature.com · 05/02/2025
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids - @pennmedicine.bsky.social go.nature.com/3EkClak
go.nature.com
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids - Nature Biotechnology
Lipid nanoparticles carrying plasmid DNA and an inflammation inhibitor enable longer transgene expression than mRNA nanoparticles.
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Reposted by Jason Luke, MD, FACP, FASCO
Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 04/02/2025
🚀 Exciting news! The brand-new #Y2025 #SITC #CompIO Webinar Series is here!!! 🎉 Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏 ✨ FREE registration: tinyurl.com/3863jp9t Let's spread the word!🚀
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Reposted by Jason Luke, MD, FACP, FASCO
Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 29/01/2025
Integrating #clinical, #pathological, #radiological, #transcriptomic data boosts prediction of #firstline #immunotherapy outcomes in metastatic #NSCLC 🚀 ✨317 patients, PET/CT, bulk RNAseq, digitized pathology => #Multimodal #AI outperform traditional methods! t.co/MfMNwuZaG9
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 16/01/2025
Excited to speak @sitcancer.bsky.social Spring Scientific: Cellular Therapy for Solid Tumors - March 12–14, San Diego. I'll discuss Development, Clinical Efficacy & Translational Analysis of PRAME Targeting with TCR Transduced T cells via IMA203. Please join us! www.sitcancer.org/education/sp...
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Reposted by Jason Luke, MD, FACP, FASCO
Waggoner Lab @labwaggoner.bsky.social · 19/12/2024
Cellular RNAs directly regulate the activity of an antiviral immune signaling complex www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @science.org @nandangokhale.bsky.social @ramlabuw.bsky.social
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 17/12/2024
Appreciated interview @oncodaily.bsky.social to discuss trends in cancer #immunotherapy, my work, as well as the role of professional societies & mentorship in career development. Focus on what you are passionate about, find great mentors & GRIND! Happy holidays! www.youtube.com/watch?v=HZqA...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 09/12/2024
Looking forward to moderating this @sitcancer.bsky.social Deep Dive into Co-stim along w Taha Mergoub featuring 3 tremendous talks from rising stars Mohamad Hamieh, Juan Osorio & Roberta Zappasodi covering novel strategies, ICI combos & CART. Please register & join us! sitcancer.org/education/we...
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Jason Luke, MD, FACP, FASCO @jasonlukemd.bsky.social · 05/12/2024
Thanks #ASCO for this recognition as a Fellow! Its an honor contributing to ASCO's important work for patients, providers & the health care community. Onward then in conquering #cancer via research, ed & the highest quality, equitable patient care! See you #ASCO25! society.asco.org/about-asco/a...
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