Toothacre et al. investigate the heterochromatic profile of the inactive X chromosome (Xi) in naive and activated B cells. Their study reveals that DNA methylation and H3K27me3 marks imprint the Xi in naive B cells, while B cell stimulation triggers Xist RNA-mediated H2AK119Ub accumulation mostly independent of PRC2 activity.

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Sierra et al. investigate the transcriptional profile and ultrastructure of the inactive X chromosome in naive and in vitro-activated B cells. Their study reveals that the X chromosomes in B cells exh...

X-Chromosome Inactivation (XCI) involves epigenetic pathways to equalize X-linked gene expression between female and male mammals. XCI is dynamic in female B cells, as cytological enrichment of Xist R...