Sign in

Feline Lindhout

@felinewlindhout.bsky.social
435 followers 164 following 20 posts

Neurobiologist studying the molecular and cellular basis of human brain development. 📍MRC-LMB, Cambridge.

PostsRepliesMedia
Reposted by Feline Lindhout
Oliver Harschnitz @harschnitz.bsky.social · 02/05/2026
Come and join our team @humantechnopole.bsky.social! We are recruiting a Senior Technician. You will be part of a collaborative and diverse team working on human stem cell biology, precise genome-engineering, and virology. More info: careers.humantechnopole.it/job/Senior-T... Please share.
11513
Feline Lindhout @felinewlindhout.bsky.social · 03/03/2026
📣🧠 We're looking for someone to join the Lancaster Lab family as a Research Support Officer (maternity cover). You'll be studying the origins of human brain specialisations using brain organoids, as part of a great team at one of the world's great research environments. mrc.tal.net/vx/mobile-0/...
mrc.tal.net
Research Support Officer - Cell Biology - Dr Madeline Lancaster - LMB 2788 - Medical Research Council
Location: Cambridge. Vacancy: Research Support Officer - Cell Biology - Dr Madeline Lancaster - LMB 2788. Closing Date: 25/03/2026, 23:55
012
Reposted by Feline Lindhout
Ido Aizenbud @idoai.bsky.social · 26/12/2024
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons. Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
720361
Reposted by Feline Lindhout
Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · 29/03/2025
EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...
meetings.embo.org
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
04019
Reposted by Feline Lindhout
Madeline Lancaster @lancasterlab.bsky.social · 03/03/2025
In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is! Led by the extraordinary @felinewlindhout.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...
0233
Feline Lindhout @felinewlindhout.bsky.social · 14/02/2025
A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀
142
Reposted by Feline Lindhout
Dr Kathleen Millen @neurodevkathy.bsky.social · 11/02/2025
A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience Thanks @frantecol.bsky.social for putting this together. Especially relevant for these dark days for USA science🧪
085
Reposted by Feline Lindhout
Cedric Boeckx @cedricboeckx.bsky.social · 22/01/2025
New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵] 🧪🧠🧫🧬
Day 50 cortical organoid stained for KI67 (red), MAP2 (magenta), Hoechst (cyan); image credit: Oliviero LeonardiDIV 28 iNeuron. Homer1 in green and Synapsin1 in purple showing co-localization of post- and pre-synapses, respectively; image credit: Elly Lewerissa
24421
Reposted by Feline Lindhout
The Interactive Fly @interactivefly.bsky.social · 04/01/2025
Okenve-Ramos, P., Gosling, R., Chojnowska-Monga, M., Gupta, K., Shields, S., Alhadyian, H., Collie, C., Gregory, E., Sanchez-Soriano, N. (2024). Neuronal ageing is promoted by the decay of the microtubule cytoskeleton. PLoS Biol, 22(3):e3002504 journals.plos.org/plosbiology/...
journals.plos.org
Neuronal ageing is promoted by the decay of the microtubule cytoskeleton
Aging is associated with structural and functional changes in neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of aging, the authors report that deteriorati...
021
Reposted by Feline Lindhout
sambooker.bsky.social @sambooker.bsky.social · 07/01/2025
We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...
nature.com
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
13315
Feline Lindhout @felinewlindhout.bsky.social · 30/12/2024
Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576 We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881 🧵 (1/n)
doi.org
Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...
2288
Feline Lindhout @felinewlindhout.bsky.social · 24/11/2024
Excited to reconnect with old science friends and meet new ones here on Bluesky! I study human neuron development using brain organoids, other in vitro models, and lots of microscopy 🧠🔬
050