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I have some exciting news (again!). I got money from the region (Occitanie) to hire a postdoc (and later an engineer / technician) to work on drug resistance evolution in malaria (P. faciparum) and…

University of California, Berkeley is hiring. Apply now!

Author summary Cancer cells often evolve resistance to treatments during therapy by acquiring specific mutations, leading to eventual relapse and treatment failure. While using multiple treatments in ...

Climate change is increasingly disrupting the relationship between locally adapted populations and the environments in which they evolved, creating an urgent need for tools that connect genomic variat...

The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...

PhD student position in Population Genomics , Department of Organismal Biology, Uppsala University

Evolution of prokaryote genomes appears to be defined by the interplay of selection for genome streamlining, deletion bias, and selection for funct...

Simulation-based inference methods are increasingly being used in population genetics due to their flexibility and ability to be applied in settings where likelihood-based methods are intractable. Per...

Nature Communications - It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core...

A new method from EMBL-EBI and collaborators offers fast, easy-to-interpret confidence scores for phylogenetic trees for pandemic preparedness.

This paper identifies systemic problems in how academic research is structured, evaluated, and supported. It argues for a realignment of incentives and institutional cultures to restore trust, enable ...

Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...

Bioinformatician, Department of Organismal Biology, Uppsala University

Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...

YouTube video by Eberhard Karls Universität Tübingen

Inside CMFI: Potenziale der Mikrobiomforschung · Episode