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Franz Baumdicker

@fbaumdicker.bsky.social

777 followers 345 following 21 posts

Mathematical and Computational Population Genetics Microbial Evolution | Machine Learning in PopGen | CRISPR-Cas | Pangenomes | HGT 🦠 ➔ 🧬 ➔ 💻 ➔ 🤔 www.baumdickergroup.de

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Franz Baumdicker @fbaumdicker.bsky.social · 22/09/2025

Only a few hours left to submit your abstract for a talk at the Machine Learning in Evolutionary Genomics conference in December in Aussois in the French alps!

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Franz Baumdicker @fbaumdicker.bsky.social · 23/04/2025

If you are interested in microbial #pangenomes, join us at @eseb2025.bsky.social in Barcelona with @bjesseshapiro.bsky.social and @annadewar.bsky.social Only two days left to submit your abstract! eseb2025.com/call-for-abs...

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Franz Baumdicker @fbaumdicker.bsky.social · 20/11/2024

The spacer deletions at the very first and last positions of CRISPR arrays deviate from a symmetric boundary effect. The reconstructed deletion rate is higher at the first positions compared to the losses at the last positions. This might have multiple reasons ...

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Franz Baumdicker @fbaumdicker.bsky.social · 20/11/2024

Consistent with this mechanism, we observe a “boundary effect”: Spacer deletions are less frequent near the leader and trailer ends of the array, potentially due to fewer neighboring repeats for alignment, while the middle of the array sees the most deletions.

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Franz Baumdicker @fbaumdicker.bsky.social · 20/11/2024

Interestingly, besides the loss of a single spacer, deletions occur often in blocks, involving an average of 2.7 spacers per event. This block deletion aligns with theories of replication slippage, where nearby repeats misalign, leading to multiple spacer deletions.

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