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Jakob Macke

@jakhmack.bsky.social
3.1K followers 715 following 57 posts

#AI4Science #CompNeuro #NeuroAI #SBI www.mackelab.org @mackelab.bsky.social · PI and Hector Fellow ELLIS Institute @ellisinsttue.bsky.social tue.ellis.eu · Prof Uni Tuebingen @ml4science.bsky.social BCCN tue.ai

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Reposted by Jakob Macke
Matthijs Pals @matthijspals.bsky.social · 28/09/2026
What are the dynamics underlying sequence working memory? To found out, we develop and analyse RNNs fitted to multi-session single-unit data of macaques. See my talk Wed 12:00, at @bernsteinneuro.bsky.social. With @jakhmack.bsky.social @mackelab.bsky.social Data from Chen et al., Neuron 2024.
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Maciej Kania @kaniamaciej.bsky.social · 25/09/2026
Train your model on a task, or fit it to biological data? And once it's optimized, what does it tell us about the brain? 🧠 In our #BernsteinConference satellite workshop, we'll discuss these questions through the lenses of different optimization methods. Check it out in Room 3.104! 🤓😉
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Machine Learning in Science @mackelab.bsky.social · 28/09/2026
The Macke lab is back at @bernsteinneuro.bsky.social in Frankfurt! 🧠🪰 This year with 2 satellite workshop talks + 5 posters on mechanistic, connectome-constrained models of the fruit fly. All posters are joint work with @srinituraga.bsky.social. Come and say hi! 👋 Details 👇 (1/8)
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Jakob Macke @jakhmack.bsky.social · 31/07/2026
500 days of summer, probably more days of work that @alanadarcher.bsky.social and others put into this-- a big data-set of over 2k single-unit recordings in 29 patients all watching the same movie, collected in the lab of Florian Mormann @humansingleneuron.bsky.social!
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Jakob Macke @jakhmack.bsky.social · 14/07/2026
We are excited to announce up to 3 PhD positions in a new project on using ML for "Extracting Probabilistic Representations in Exponential Quantum Spaces" (EXPRESSO) with @philipphennig.bsky.social , @mariokrenn.bsky.social, Igor Lesanovsky, @gmartius.bsky.social in the @ml4science.bsky.social.
quantiki.org
PhD Positions in Quantum Physics and Machine Learning | Quantiki
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Roxana Zeraati @roxana-zeraati.bsky.social · 07/07/2026
Our paper "Neural timescales from a computational perspective" is finally out in @natneuro.nature.com: www.nature.com/articles/s41... We discuss how computational models and methods can distill empirical observations on neural timescales into quantitative, testable theories of brain computation.
nature.com
Neural timescales from a computational perspective - Nature Neuroscience
This review integrates computational approaches to provide a unified view on how data analysis methods, biophysical mechanistic models and machine learning approaches can help to uncover the origins a...
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Machine Learning in Science @mackelab.bsky.social · 06/07/2026
ModelSMC: we frame LLM-based scientific model discovery as Bayesian inference. Sequential Monte Carlo over executable model structures, with the LLM as a probabilistic proposal mechanism. 📍 Wed Jul 8, at 2:30–4:15 PM KST in Hall A #3512 📄 arxiv.org/abs/2602.18266 🧵 bsky.app/profile/mack...
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Jakob Macke @jakhmack.bsky.social · 02/07/2026
Happy to have joined the ELLIS Institute! Excited to be working with the PIs at the Institute and the ELLIS network more broadly!
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Machine Learning in Science @mackelab.bsky.social · 02/07/2026
We congratulate @matthijspals.bsky.social on his successful PhD defense! During his time in the Mackelab, he used RNNs to link neural activity with underlying mechanisms. Now he moved on to a Postdoc position in @durstewitzlab.bsky.social at the ZI Mannheim and the University of Heidelberg.
Left to right: Philipp Berens, Anna Levina, Matthijs Pals, Peter Dayan, Jakob Macke.
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Machine Learning in Science @mackelab.bsky.social · 26/06/2026
New paper: We recast automated scientific model discovery with LLMs as Bayesian inference! LLMs write code and carry domain knowledge, great for proposing models. The key idea: discovery is inference, not just generation. What distribution of models explains the data? 🧵 arxiv.org/abs/2602.18266
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ML for Science @ml4science.bsky.social · 16/06/2026
We are recruiting several Early Career Research Group Leaders for Machine Learning in Science (m/f/d; E14 TV-L, 100%) in Tübingen! Open to researchers directly after their PhD or with postdoctoral experience. Application deadline: July 15, 2026. More info: uni-tuebingen.de/en/128980#c2... 1/2
Image with the text: Open Positions: Early Career Research Group Leaders for Machine Learning in Science (m/f/d, E14 TV-L, 100%). Application Deadline: July 15, 2026.
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Jakob Macke @jakhmack.bsky.social · 14/05/2026
Great opportunity: The Leibniz Institute for Neurobiology @linmd.bsky.social + University @uni-magdeburg.de Magdeburg are hiring a Full Professor/Research Group Head in Integrative Neurobiology, especially computation, theory neurotech! Apply by 29 May 2026 ncloud.lin-magdeburg.de/s/cnSj2Ys5YE...
ncloud.lin-magdeburg.de
Ausschreibung W3 Integrative Neurobiology E.pdf
LIN-Nextcloud v2.0 - Datenaustausch leicht gemacht
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Jakob Macke @jakhmack.bsky.social · 30/04/2026
For its 50th birthday*, MLSS is back in Tübingen— come to beautiful Tübingen to learn about ML from great speakers, and, most importantly, meet lots of other students and researchers!!!
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Adam Marblestone @adammarblestone.bsky.social · 24/04/2026
zenodo.org/records/1969...
zenodo.org
How to obtain a complete human connectome at synaptic resolution within the next decade
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ML for Science @ml4science.bsky.social · 22/04/2026
We're excited to welcome our 2026 AIMS Fellows: Ndim Handson Nsani, Arlette Musanabera, Vongai Mitchell Makuwaza, Dzodzoenyenye Senanou and Benedict Ositadinma Ejelonu have recently arrived in Tübingen and started their nine-month research visit. We wish them a productive and rewarding stay!
The new AIMS fellows (from left to right): Ndim Handson Nsani (AIMS Rwanda), Arlette Musanabera (AIMS Rwanda), Vongai Mitchell Makuwaza (AIMS Senegal), Dzodzoenyenye Senanou (AIMS Senegal) and Benedict Ositadinma Ejelonu. - Photo Credit: Sebastian Schwenk/University of Tübingen.
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sbi - Simulation-based inference @sbi-devs.bsky.social · 09/04/2026
sbi v.0.26.1 is out 🎉. We initially planned this release for January, but then the Grenoble Hackathon and GSoC applications happened. Now we have three new methods, better neural nets, cleaner internals, better docs, and 9 new contributors 🤗. Highlights below 🧵
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Jakob Macke @jakhmack.bsky.social · 28/03/2026
We’re launching a new AI Methods & Software Hub in the ML cluster and are looking for a Director to build and lead it! Shape how ML/AI and software drive scientific discovery—in close collaboration with AI and domain scientists—within an extremely vibrant and collaborative ecosystem!
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John Tuthill @tuthill.bsky.social · 24/03/2026
🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...
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Jakob Macke @jakhmack.bsky.social · 23/03/2026
How academic are different cities in Germany? The one definite ranking. #exinit @unituebingen.bsky.social
bar chart, different cities in Germany, sorted by number of excellence clusters per 100.000 citizens. Tübingen leads with 5.78, second is Jena with 1.82
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Katrin Franke @katrinfranke.bsky.social · 21/02/2026
🚨 We're hiring: Research Coordinator for CRC Robust Vision @unituebingen.bsky.social Take a leading role in our DFG funded consortium in neuroscience, ML & CV MSc/PhD + science mgmt. Apply by Mar 15 👇 join our team w/ @jakhmack.bsky.social @bethgelab.bsky.social uni-tuebingen.de/en/universit...
uni-tuebingen.de
Coordinator (m/f/d, E13 TV-L, 75%)
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Tübingen AI Center @tuebingen-ai.bsky.social · 19/02/2026
Hiring now! 📢 The CRC 1233 Robust Vision consortium at @unituebingen.bsky.social is looking for a Research Coordinator to lead science management, support project execution, and help steer our interdisciplinary research in neuroscience, machine learning and computer vision.
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Maria Geffen @geffenlab.bsky.social · 31/01/2026
A special year for the Cajal Course in Computational Neuroscience: the BRAIN Prize winners Haim Sompolinsky and Larry Abbott will join us as keynote speakers. And we will bring you the same great roster of instructors as every year. Applications are now open! cajal-training.org/on-site/comp...
cajal-training.org
The Brain Prize Course - Computational and Theoretical Neuroscience - CAJAL
[…]
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Jan Boelts @janboelts.bsky.social · 23/01/2026
SBI Hackathon Grenoble is a wrap! 🎉 35 researchers and a great hybrid format of 1.5 days of tutorials + 1.5 days of applied hackathon. Many went from “having heard of sbi” to applying full SBI workflows to their own research projects. 🧵👇
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Machine Learning in Science @mackelab.bsky.social · 13/01/2026
Happy 2026 everyone! Two freshly minted PhDs 🧑‍🎓emerged from our lab at the end of last year. We congratulate Dr Julius Vetter (@vetterj.bsky.social) and Dr Guy Moss (@gmoss13.bsky.social)! Here seen celebrating with the lab 🎳. 1/3
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ML for Science @ml4science.bsky.social · 15/12/2025
📢We’re hiring: W3-Professorship in Machine Learning in Physics @unituebingen.bsky.social! What we’re looking for: Established research profile in a core area of #physics (condensedmatter, quantum or theoretical particle physics), strong track record in research questions related to #ML and/or #AI.
Tübingen AI Research Building, where the Cluster of Excellence "Machine Learning" is based.
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Jakob Macke @jakhmack.bsky.social · 09/12/2025
Congrats to all the ERC COG recipients, of course especially to the 5 from @unituebingen.bsky.social, and even more so to the @ml4science.bsky.social members @tobiasuhauser.bsky.social and @andreasgeiger.bsky.social (AI assistants!)!!! erc.europa.eu/system/files...
erc.europa.eu
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Jakob Macke @jakhmack.bsky.social · 04/12/2025
Come work with us!!!
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Richard Gao @rdgao.bsky.social · 03/12/2025
Finally got the job ad—looking for 2 PhD students to start spring next year: www.gao-unit.com/join-us/ If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply! I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
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Jakob Macke @jakhmack.bsky.social · 02/12/2025
We were asked to do an online training on 'AI awareness' by admin. I almost failed the test, as I was not aware of some of the fundamental limitations of #AI4Science.
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Jakob Macke @jakhmack.bsky.social · 01/12/2025
Not going to NeurIPS Nor Eurips, but the lab is showing cool new work on SBI and differentiable biophysics, do check it out and talk to them (we also have open positions …)!
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Jakob Macke @jakhmack.bsky.social · 01/12/2025
@gmoss13.bsky.social et al sending SBI to space 🚀*!!!
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ML for Science @ml4science.bsky.social · 24/11/2025
On our blog: For decades, brain simulations have either been largely simplified, or they could not perform cognitive tasks. #JAXLEY, a new AI tool, opens possibilities to build brain simulations that overcome both limitations: www.machinelearningforscience.de/en/jaxley-ai... #AIforScience
machinelearningforscience.de
AI tool for brain simulations links cellular detail to cognitive functions — MACHINE LEARNING for science
For decades, brain simulations have either been largely simplified, or they could not perform cognitive tasks. A new AI tool opens possibilities to build brain simulations that can achieve both.
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Jakob Macke @jakhmack.bsky.social · 28/11/2025
Possibly the best part of the job: The amazing students and scientists we get to work with!
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Jakob Macke @jakhmack.bsky.social · 21/11/2025
Simulation-based inference has really become a commonly used tool for parameter inference across many fields and applications. We (finally...) got together to write a tutorial introduction and guide to (hopefully) help users get started and navigate the different methods and diagnostics!
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Michael Deistler @deismic.bsky.social · 13/11/2025
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
nature.com
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
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ML for Science @ml4science.bsky.social · 13/11/2025
Great new work from the labs of @jakhmack.bsky.social and @philipp.hertie.ai! The software Jaxley enables brain simulations which both imitate the processes in the brain in detail and can solve challenging cognitive tasks. Press release of @unituebingen.bsky.social: uni-tuebingen.de/en/universit...
uni-tuebingen.de
Software optimizes simulations of the brain
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Jakob Macke @jakhmack.bsky.social · 13/11/2025
Congrats to @deismic.bsky.social and everyone for getting this out!
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Tim Vogels @tpvogels.bsky.social · 06/10/2025
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
biorxiv.org
An ion channel omnimodel for standardized biophysical neuron modelling
Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron propert...
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sbi - Simulation-based inference @sbi-devs.bsky.social · 17/10/2025
🎉 sbi participated in GSoC 2025 through @numfocus.bsky.social and it was a great success: our two students contributed major new features and substantial internal improvements: 🧵 👇
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C3N @c3neuro.bsky.social · 30/09/2025
Hello Frankfurt 🇩🇪 - We are excited to share the latest result from our group and collaborators at @bernsteinneuro.bsky.social 🚀🧠 #BernsteinConference Thanks to @brainloops.bsky.social, @ekfstiftung.bsky.social and @cherish-msca.bsky.social for supporting these projects and our scholars.
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Machine Learning in Science @mackelab.bsky.social · 30/09/2025
The Macke lab is well-represented at the @bernsteinneuro.bsky.social conference in Frankfurt this year! We have lots of exciting new work to present with 7 posters (details👇) 1/9
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sbi - Simulation-based inference @sbi-devs.bsky.social · 09/09/2025
From hackathon to release: sbi v0.25 is here! 🎉 What happens when dozens of SBI researchers and practitioners collaborate for a week? New inference methods, new documentation, lots of new embedding networks, a bridge to pyro and a bridge between flow matching and score-based methods 🤯 1/7 🧵
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Seth Axen 🪓 @sethaxen.com · 31/07/2025
Sharing this here a bit late, but @vstaros.bsky.social and I wrote a little something about our experience contributing to the @sbi-devs.bsky.social (simulation-based inference) hackathon. @mlcolab.org @mackelab.bsky.social We were obviously very hungry while writing.
mlcolab.org
A retrospective on the 2025 SBI Hackathon
You walk into a bakery, take one bite of a still-warm pastry, and think: “Whoa - there’s rye flour, a hint of orange zest, maybe cardamom… and is that buckwheat honey?” From that single taste you begi...
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Daniel Gedon @danielged.bsky.social · 23/07/2025
My first paper on simulation-based inference (SBI) as part of @mackelab.bsky.social! Exciting work on adapting state-of-the-art foundation models for posterior estimation. Almost plug-and-play, and surprisingly effective. Paper/code in thread below 🧵
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Jakob Macke @jakhmack.bsky.social · 23/07/2025
I have been genuinely amazed how well tabpfn works as a density estimator, and how helpful this is for SBI ... Great work by @vetterj.bsky.social, Manuel and @danielged.bsky.social!!
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ML for Science @ml4science.bsky.social · 16/07/2025
Together with #AIMS, the African Institute for Mathematical Sciences, we have an exciting position to fill: The AIMS - Tübingen Junior Research Chair in Machine Learning for Science! 1/2
Formulas and numbers from the field of machine learning written in white chalk on a blackboard
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ML for Science @ml4science.bsky.social · 16/07/2025
Come work with us in Tübingen! Our new professor @mariokrenn.bsky.social is looking for PhDs and postdocs! The group builds #AI systems for discovering new concepts, experiments and ideas in #physics. Find out more: uni-tuebingen.de/en/128980#c2... #AIforScience
Mario Krenn (right) and eight members of his group stand next to each other for a group photo, with green plants in the background.
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Anna Beyeler 🐝 @anna-beyeler.bsky.social · 10/07/2025
👨‍💻 Open PI position in our institute 👨‍💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us ! www.fens.org/careers/job-... @neuromagendie.bsky.social @neurobordeaux.bsky.social
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Jakob Macke @jakhmack.bsky.social · 11/06/2025
Sbi can take you places … very proud about @gmoss13.bsky.social et als work, a wild and serendipitous collaboration made possible by @ml4science.bsky.social!
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François Rozet @francois-rozet.bsky.social · 03/06/2025
I always find the figures from the @mackelab.bsky.social really clear and pretty! For example in arxiv.org/abs/2404.09636.
arxiv.org
All-in-one simulation-based inference
Amortized Bayesian inference trains neural networks to solve stochastic inference problems using model simulations, thereby making it possible to rapidly perform Bayesian inference for any newly obser...
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