iiinova — where your digital self keeps evolving

Reposted by Ingo Greger

Ignacio Vega-Vásquez @igvegvas.bsky.social · 07/08/2026

(4/4) Mega-ExM starts to bring ultrastructural detail in cells toward what was previously limited to cryo-ET, while keeping fluorescence microscopy flexibility. www.biorxiv.org/content/10.6... Hope you find it interesting—and thanks to everyone involved! #FluorescenceFriday #MegaExM

biorxiv.org

Structural cell biology by mega-expansion microscopy

Structural characterization of macromolecular assemblies within intact cells remains one of the central challenges in cell biology. While cryo-electron tomography provides unparalleled structural info...

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Ingo Greger @igreger.bsky.social · 30/01/2026

Great new work from Ben Ryskeldi-Falcon's lab on TDB-43 www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 12/12/2025

A multidisciplinary study from @igreger.bsky.social’s group in the LMB’s Neurobiology Division details the rich diversity of GluA4 AMPA receptors in the cerebellum. Read more here: www2.mrc-lmb.cam.ac.uk/distinct-amp... #LMBResearch

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Ingo Greger @igreger.bsky.social · 02/07/2025

Happy about our new paper in Nature rdcu.be/eukUB The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 01/07/2025

New research from @igreger.bsky.social group in the LMB’s Neurobiology Division, show that GluA3 adopts a structural organization that substantially diverges from all the other AMPA receptors. Read more: www2.mrc-lmb.cam.ac.uk/architecture... #LMBResearch

Cryo-EM maps of GluA2/TARP-γ2 (red) and GluA3/TARP-γ2 (green)

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Reposted by Ingo Greger

Jesper Sjöström @pjsjostrom.bsky.social · 14/04/2025

🧪 The Sjöström Lab in Montreal is looking for a postdoc! We study cortical circuits, synaptic plasticity, and NMDAR signalling using custom 2-photon microscopy and optogenetics. We seek candidates with strong patch-clamp and/or 2-photon imaging expertise, and a relevant publication track record.

We are looking for an outstanding postdoctoral researcher to join our team at McGill University. The Sjöström lab studies neocortical circuits, with a focus on synaptic plasticity, NMDA receptor signaling, 2-photon optogenetics, and advanced 2-photon imaging. We are particularly interested in candidates with strong expertise in whole-cell patch-clamp electrophysiology and/or 2-photon imaging, and a solid track record of relevant publications.
Applicants should be experienced with whole-cell recordings and/or cutting-edge imaging approaches. Responsibilities will include performing experiments, analyzing and presenting data locally and internationally, writing manuscripts, and occasionally mentoring junior lab members.
Our lab is based at the Research Institute of the McGill University Health Centre, in vibrant, multicultural Montreal—a city that offers exceptional quality of life. McGill and its neighbouring universities form one of the most dynamic neuroscience communities in the world.
For examples of our current directions, see:
• Chou et al The Innovation 2025, www.cell.com/the-innovation/fulltext/S2666-6758(24)00173-5
• Wong et al Neuron 2024, www.cell.com/neuron/fulltext/S0896-6273(23)00767-5
The position is fully funded with a competitive salary. Candidates are also expected to apply for external funding, for which we provide strong support. Opportunities are available for both Canadian and international applicants.
To apply, please send a Letter of Intent, CV, brief research statement, and contact information for three referees to Dr. Jesper Sjöström (jesper.sjostrom@mcgill.ca). In the subject line, include "Postdoc" followed by your name.
Application deadline: July 31, 2025.
Website: http://plasticity.muhc.mcgill.ca
McGill University is committed to diversity and equity in employment.

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 04/04/2025

Join us at 11am (BST) on Monday 7th April for an #LMBSeminar from Rod MacKinnon of Rockefeller University. He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’ More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

Rod MacKinnon
Rockefeller University
Higher order transient structures and the principles of dynamic connectivity in membrane signaling
Monday 7th April at 11am (BST)

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Reposted by Ingo Greger

Rick Huganir @rhuganir.bsky.social · 07/03/2025

Interview with me about impact of NIH budget cuts on the American people. It will have ripple effects not only our health but also on state economies across the country. March in support of science tomorrow! apnews.com/article/trum...

apnews.com

Jobs lost in every state and lifesaving cures not discovered: Possible impacts of research cuts

Ripple effects of the Trump administration's crackdown on U.S. medical research promise to reach every corner of America.

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Ingo Greger @igreger.bsky.social · 26/02/2025

In @elife.bsky.social: Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP doi.org/10.7554/eLif...

doi.org

Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/02/2025

Great position for a postdoc to join @igreger.bsky.social’s group in the LMB’s Neurobiology Division, using diverse methods to study synaptic AMPA glutamate receptors. Read more about the job here: www.nature.com/naturecareer... Apply by 20 FEB #PostdocJobs #ScienceJobs

Ingo Greger sat in front of a computer screen displaying an AMPA Receptor structure

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Ingo Greger @igreger.bsky.social · 25/01/2025

We're looking for a postdoc with a strong interest in the structure, function and cell biology of glutamate receptors and excitatory synapses. www.nature.com/naturecareer...

nature.com

Postdoctoral Scientist - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12835302

Postdoctoral Scientist

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Ingo Greger @igreger.bsky.social · 09/01/2025

www.science.org/content/arti...

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Reposted by Ingo Greger

Jake Watson @jakefwatson.bsky.social · 27/10/2024

Recording synaptic minis (mEPSCs)? We have a new paper trying to better understand how recorded datasets match synaptic changes. In short, they don't.. More info below, and the preprint here: biorxiv.org/content/10.1101/2024.10.26.620084v1

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 29/11/2024

Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of... #LMBResearch

Model depicting the early steps during production of a membrane protein

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Reposted by Ingo Greger

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/11/2024

Considering a PhD in molecular biology? There’s still time to apply to join the LMB in October 2024. Applications close on 3rd DEC. Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...

Join the LMB's PhD programme!
Applications now open for October 2025
Deadline 3rd December 2024

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Ingo Greger @igreger.bsky.social · 27/11/2024

Happy CaMKII days in China, with Roger and Howard Schulman

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