The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

Flury, Aljayousi, et al. pinpoint a novel microglia phenotype in Alzheimer’s disease characterized by a stress-related signaling pathway. Activating this pathway induces microglia to secrete toxic lipids, which harms brain health. Blocking microglial stress or lipid synthesis in the brain reverses symptoms of Alzheimer’s disease.

How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that …