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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

Congratulations to Atar, Alex and Benjamin. With a system called micDROP, there is only one way to end a thread!

Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

Out of 10 IDRs, 8 colocalized indiscriminately, whereas TDP43 and UBQ2 formed spatially distinct condensates. In TDP43 a segment forming a transient α-helix (see work by @nicolasluxfawzi.bsky.social) determined self-recognition specificity as a truncated mutant co-localized with all other IDRs.

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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

The Csat we measured span about two orders of magnitude, and stickier sequences condensed at lower concentration (R = -0.72). See doi.org/10.1002/pro.... for our latest stickiness scale

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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

micDROP (_M_ultivalent _I_DRs forming _C_onstitutive _DROP_lets) consists of IDRs of interest fused to a fluorescent protein and to a mini-ferritin (12-mer) scaffold. We express them in yeast, quantify the dilute phase in 1000s of cells, which in turn enables inferring Csat for a particular IDR.

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Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...

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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

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Emmanuel Levy's lab @elevylab.bsky.social · 24/09/2026

Amazingly clever use of supramolecular protein self-assemblies as in vivo reporters and sensors

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Reposted by Emmanuel Levy's lab

Sophie G Martin @sophiemartinlab.bsky.social · 03/03/2026

You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!

mocel.unige.ch

Contact/Job - Department of Molecular and Cellular Biology - UNIGE

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Reposted by Emmanuel Levy's lab

European Conference on Computational Biology @eccb-europe.bsky.social · 04/03/2026

📣 #ECCB2026 proceedings deadline extended to 16 March 13:00 CET Submit to 1 of our 6️⃣ sessions: 🔹 Genomics 🔹 Transcriptomics & gene regulation 🔹 Proteins & structural biology 🔹 Systems biology 🔹 Environmental bioinformatics 🔹 ELIXIR Communities 👉 More info: eccb2026.org/call-proceedings

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Emmanuel Levy's lab @elevylab.bsky.social · 09/02/2026

This has only possible thanks to the herculean work of Ella Livnah in @london_lab who led the work, and the contributions from our many colleagues at @weizmanninstitute.bsky.social and @biology-unige.bsky.social.

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Emmanuel Levy's lab @elevylab.bsky.social · 09/02/2026

In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT

The image illustrates a principle by which homomers can be polymerized by mutations or by multivalent small molecules.

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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 10/12/2025

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

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Rosana Collepardo @rcollepardo.bsky.social · 05/12/2025

Our Science paper is out! Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group News: bit.ly/4avnkAr and bit.ly/3XBGVHS Great perspective by @vram142.bsky.social +K Zhang

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David Drubin @drubin.bsky.social · 02/12/2025

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

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EMBL @embl.org · 27/11/2025

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

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Emmanuel Levy's lab @elevylab.bsky.social · 16/10/2025

Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧 Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social www.sciencedirect.com/science/arti...

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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 15/09/2025

Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.

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Molecular Systems Biology @molsystbiol.org · 07/10/2025

10/2025 Issue ➡️ www.embopress.org/toc/17444292... reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social

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Emmanuel Levy's lab @elevylab.bsky.social · 05/10/2025

@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!

This month's cover highlights the article Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system by Emmanuel Levy, Hector Garcia-Seisdedos and colleagues. Yeast cells harboring mutation-induced filaments of folded proteins or “agglomerates”. The filaments appear large and disruptive, but surprisingly, Levin et al. reveal they are largely inert and non-toxic, unlike aggregates of misfolded proteins.

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 21/09/2025

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n 📄 www.nature.com/articles/s41... 💿 mmseqs.com

nature.com

GPU-accelerated homology search with MMseqs2 - Nature Methods

Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

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Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025

This work has been a long and exciting journey, taking my lab into yeast proteomics and protein functions. All possible thanks to the great work of Tal Levin, Hector Garcia-Seisdedos and @arseniylobov.bsky.social in particular. Also big thanks to our collaborator Ohad Medalia at ZurichU.

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Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025

The key experiments and findings of the paper are summarized in this graphical abstract:

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Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

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Biology-UNIGE @biology-unige.bsky.social · 22/08/2025

Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social‬ @sciencesunige.bsky.social

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