iiinova — where your digital self keeps evolving

Emmanuel Levy's lab

@elevylab.bsky.social

Structural & Systems Biology Lab @ University of Geneva | Exploring protein & proteome assemblies | Structured thoughts, intrinsically disordered views

Posts Replies Media

Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

Congratulations to Atar, Alex and Benjamin. With a system called micDROP, there is only one way to end a thread!

000

Emmanuel Levy's lab @elevylab.bsky.social · 25/09/2026

It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...

1199

Emmanuel Levy's lab @elevylab.bsky.social · 09/02/2026

In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT

The image illustrates a principle by which homomers can be polymerized by mutations or by multivalent small molecules.

1216

Emmanuel Levy's lab @elevylab.bsky.social · 16/10/2025

Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧 Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social www.sciencedirect.com/science/arti...

0153

Emmanuel Levy's lab @elevylab.bsky.social · 05/10/2025

@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!

This month's cover highlights the article Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system by Emmanuel Levy, Hector Garcia-Seisdedos and colleagues. Yeast cells harboring mutation-induced filaments of folded proteins or “agglomerates”. The filaments appear large and disruptive, but surprisingly, Levin et al. reveal they are largely inert and non-toxic, unlike aggregates of misfolded proteins.

072

Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025

The key experiments and findings of the paper are summarized in this graphical abstract:

110

Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

1278