The order Thermococcales is unusual among Archaea in being known primarily from hundreds of lab-cultured isolates rather than metagenome-assembled genomes. Such cultivation is powerful for comparative...

This platform identifies phages capable of infecting specific bacterial strains using genome sequences alone and could enable rational phage-therapy design and precision microbiome engineering.

Phosphorothioates, stereospecific modifications of the RNA phosphate backbone in anaerobic archaea, expand the epitranscriptome beyond nucleobases and ribose sugars. Installed by Esti enzymes at conse...

We characterized the vertical profiles of archaeal community composition, function, co-occurrence networks, and assembly mechanisms in mangrove sediments across six depth intervals. Deep sediments ho....

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Pathogenicity—the ability to cause infectious disease—is widespread among bacteria and eukaryotes but conspicuously absent from archaea, the third domain of life. To understand why archaea are non-pat...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Cellular processes often exhibit irreversible state transitions even after external signals responsible for a transition are withdrawn. Long-standi...

A groundbreaking study hints at a hazy boundary between “life” and “non-life,” as well as two distinct origins of biology on Earth

In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a c...

The last common ancestor of all living things may not have been alive at all

From chemical building blocks, scientists have created synthetic cells that have most of the hallmarks of life.

To prepare for DNA replication, a short region of DNA base-pairs must be broken, termed melting, allowing a helicase to gain a foothold on an isolated DNA strand. Here, authors use single-particle cry...

Melanie Mitchell probes the jagged landscape of AI and its uncertain future.

Réflexion, planification stratégique, analyse des données, génération d’hypothèses de travail, enseignement universitaire… La montée en puissance des outils d’intelligence artificielle, en particulier...

Many faculty say this is not the job they signed up for. They need leaders who see this and who are looking out for them.

Bacteria tune transcription bursts through early termination, enabling switch-like and gradual adaptation to nutrients.

All of biology is transient. Over time, a population of identical cells can change so that some subgroups exhibit different behaviors — everything from varying sizes to the expression of certain prote...

The membrane lipids of archaea differ from those of bacteria and eukarya in backbone stereochemical configuration, chemical linkage type, and hydrophobic chain structure, a fundamental dichotomy term...

Abstract. Replicative DNA synthesis is distributed among several DNA polymerases (DNAPs) in both Bacteria and Eukarya. The division of synthesis permits sp

Nontuberculous mycobacteria (NTM) are increasingly recognized as opportunistic pathogens in people with cystic fibrosis (pwCF), but the ecological fac…

Researchers from Brown University and their collaborators have developed a new way to measure the properties of cells—an important development, they say, because accurate measurements of changes in cell elasticity can be used to better understand diseases, diagnose patient symptoms and provide more accurate prognoses.

Oxidative stress induces damage to DNA, RNA, and nucleotide pools. Unlike well-studied DNA damage, the formation of RNA damage and the impact of an...

Biology is at the precipice of a new era where AI accelerates and amplifies the ability to study how cells operate, organize, and work as systems, revealing why disease happens and how to correct it. ...

Diversity-generating retroelements are engineered for directed evolution in E.coli.

How a discovery in the 1970s changed the theory of the origin of complex life on earth.

A strategy preserves complex networks in lower dimensions with discriminative node representation, enhancing PPI network analysis.

There’s been a fair bit of recent discussion about why most biologists are (uncritically) adaptationists. I don’t dispute this but think it’s worth reconsidering why. Some have argued that this is bec...

The discovery of Asgard archaea about a decade ago has greatly reshaped our understanding of archaeal evolution and the origin of eukaryotes. Asgards are currently thought to be the closest prokaryoti...

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distin...

MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, making production more efficient.

We have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that t...

Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and p...