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Nobuto Takeuchi

@nobuto.bsky.social
71 followers 10 following 6 posts

A scientist interested in the evolution of biological complexity. Uses computational modelling and genome sequence analysis. Based at the University of Auckland, New Zealand. All views my own.

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Nobuto Takeuchi @nobuto.bsky.social · 28/08/2026
Sharing our new paper, led by PhD student Daniel Harrison. We propose that archaea aren't pathogenic because those living in eukaryotic hosts lack a metabolic prerequisite, and those with the prerequisite don't live in eukaryotic hosts. #microsky doi.org/10.1128/mbio...
journals.asm.org
Why are archaea not pathogenic? A hypothesis based on metabolism-habitat covariation | mBio
Pathogenicity—the ability to cause infectious disease—is widespread among bacteria and eukaryotes but conspicuously absent from archaea, the third domain of life. To understand why archaea are non-pat...
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Nobuto Takeuchi @nobuto.bsky.social · 05/06/2026
Sharing our new paper, led by Dominic Devlin, now in Shuji Ishihara’s group at UTokyo. We show that 𝗺𝗼𝗿𝗽𝗵𝗼𝗴𝗲𝗻𝗲𝘁𝗶𝗰 𝗿𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗶𝗯𝗶𝗹𝗶𝘁𝘆 can evolve as a by-product of complex morphogenesis, even without direct selection for reproducibility. doi.org/10.1371/jour...
doi.org
Cell differentiation can underpin the reproducibility of morphogenesis
Author summary An astounding property of multicellular animals is the reliable formation of morphological structures, such as organs and limbs. How does this reliable formation, termed reproducibility...
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Nobuto Takeuchi @nobuto.bsky.social · 05/06/2026
Belatedly sharing an opinion piece with Kuni Kaneko. We propose that 𝘁𝗵𝗲 𝗰𝗲𝗻𝘁𝗿𝗮𝗹 𝗱𝗼𝗴𝗺𝗮 is one instance of a more general pattern that has evolved repeatedly across levels of biological organisation. doi.org/10.1098/rstb...
doi.org
Generalizing the central dogma as a cross-hierarchical principle of biology
Abstract. The central dogma of molecular biology, as originally proposed by Crick, asserts that information passed into protein cannot flow back out. This
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Nobuto Takeuchi @nobuto.bsky.social · 17/12/2024
I gave a talk on the 𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧 𝐨𝐟 𝐫𝐞𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐯𝐞 𝐝𝐢𝐯𝐢𝐬𝐢𝐨𝐧 𝐨𝐟 𝐥𝐚𝐛𝐨𝐫 at Cambridge University @tlmcambridge.bsky.social. Our model predicts that this division evolves when relatedness is sufficiently low, contrary to textbook explanations. Watch here: www.youtube.com/watch?v=JMrN... #evolution #compbio
youtube.com
Nobuto Takeuchi - Cheater-driven evolution of reproductive division of labour
YouTube video by Theory of Living Matter Group - Cambridge U
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Reposted by Nobuto Takeuchi
Journal of Evolutionary Biology @jevbio.bsky.social · 17/09/2024
How did life’s template-catalyst division evolve? Fu and @nobuto.bsky.social show this can evolve without cells in 2D space through symmetry breaking. Evolution is driven by high diffusion rates, protecting against cheaters/parasites: academic.oup.com/jeb/advance-...
academic.oup.com
Evolution of the division of labour between templates and catalysts in spatial replicator models
Abstract. The central dogma of molecular biology can be conceptualised as the division of labour between templates and catalysts, where templates transmit
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Nobuto Takeuchi @nobuto.bsky.social · 24/01/2024
Our new modelling paper is out! It shows that Black Queen dynamics can accelerate the evolution of new gene functions by, say, 10-fold. Here is the idea: when gene products are shared btw cells, cheaters don't have to maintain their corresponding genes, which can freely explore sequence space.
doi.org
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Nobuto Takeuchi @nobuto.bsky.social · 29/11/2023
My PhD student Dominic Devlin's first paper was published. We review recent work suggesting that germline-soma separation is widespread among metazoans beyond insects & vertebrates. Germline-soma separation is distinct from early germline segregation, although they are often conflated.
doi.org
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