Steve Kay @drstevekay.bsky.social · 16/05/2026urldefense.com/v3/__https:/...urldefense.comTime matters: circadian genetics and the molecular logic of human health and diseaseNature Reviews Genetics - The circadian clock controls transcriptional and signalling networks across tissues to maintain homeostasis, with pathological consequences to its disruption. Kuo et al.... 040
Reposted by Steve KayNaomi Mittet @naolimit.bsky.social · 19/04/2026"Taken together, our rigorous quantification of sleep in phototransduction genetic mutants reveals the key role of visual input in promoting sleep." @kofanchen.biologists.social.ap.brid.gy www.sciencedirect.com/science/arti...sciencedirect.comA day sleep promoting role of phototransduction in Drosophila melanogasterThe daily sleep-wake cycle is a conserved behaviour defined by locomotion quiescence and enhanced responsive threshold to sensory stimuli. Both the ci… 062
Reposted by Steve KayNature Portfolio @natureportfolio.nature.com · 24/01/2026US researchers speak with Nature Careers about the human toll of lay-offs, funding cuts and attacks on science one year after Donald Trump returned to the White House. #Academicsky 🧪 go.nature.com‘Shattered’: US scientists speak out about how Trump policies disrupted their careersResearchers lay bare the human toll of lay-offs, funding cuts and attacks on science one year after the president’s return to the White House. 13616
Steve Kay @drstevekay.bsky.social · 03/01/2026JCI - Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels www.jci.org/articles/vie... in collaboration with Jeremy Rich @unclineberger.bsky.socialjci.org JCI - Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels 051
Reposted by Steve KayScience Magazine @science.org · 01/01/2026In the first #ScienceEditorial of 2026, H. Holden Thorp focuses on #AI, discussing how it “will allow the scientific community to do more if it picks the right ways to use it.” He revisits the journals’ policies and approaches related to AI. Read more: scim.ag/4qzSdJ5 6347
Reposted by Steve Kay𝔅𝔲𝔱𝔱𝔬𝔫𝔰 𝔒'𝔊𝔥𝔬𝔲𝔩𝔦𝔥𝔞𝔫 @johnxuandou.bsky.social · 13/08/2025This is one of the most beautiful things I have witnessed, the craft here is impeccable. 461222318467
Reposted by Steve KayRoland Hatzenpichler @environmicrobio.bsky.social · 14/11/2025“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”science.orgU.S. Congress considers sweeping ban on Chinese collaborationsResearchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students 56583299
Reposted by Steve KayJeremy Berg @jeremymberg.bsky.social · 10/11/2025Very well done story on 60 Minutes about the harms of grant terminations and freezes at Harvard with Joan Brugge, Don Engbar, David Liu, and a very compelling young cancer patient, now cured with Liu's technology. Transcript and video here www.cbsnews.com/news/researc...cbsnews.comBattle between Trump and universities hurting scientific research in need of federal fundingFederal research funding to universities has fueled breakthroughs for years. The White House is pressuring universities to align with the president's political agenda, or risk losing their funding. 315060
Reposted by Steve KayNature Chemical Biology @natchembio.nature.com · 15/09/2025Genetically incorporating environment-sensitive noncanonical amino acids containing rotor-based fluorophores to target proteins enables real-time visualization of microenvironment changes in protein substructures www.nature.com/articles/s41...nature.comReal-time imaging of protein microenvironment changes in cells with rotor-based fluorescent amino acids - Nature Chemical BiologyThe use of bulky protein tags and the limited positions available for probe introduction restrict current methods for studying protein microenvironments at high spatial resolution. Here the authors genetically incorporate small environment-sensitive fluorescent amino acids to visualize real-time microenvironmental changes at specific protein substructures. 093
Reposted by Steve KayPlantEvolution 🌱🌾 @plantevolution.bsky.social · 23/07/2025Jennifer Nemhauser’s and my tribute to our amazing friend and mentor, the extraordinary Joanne Chory. Read about our personal and professional reminiscences. Thanks to all who provided background for this. www.pnas.org/doi/10.1073/...pnas.orgJoanne Chory (1955–2024): Plant geneticist extraordinaire | PNASJoanne Chory (1955–2024) was a pioneering biologist whose research transformed our understanding of plant growth and development. Her groundbreakin... 38130
Reposted by Steve KayArghavan Salles, MD, PhD @arghavansallesmd.medsky.social · 27/08/2025Here’s some of what scientists told us: "The past five months are by far the worst I've experienced in my science career (from grad student to professor) over the last 30-plus years because we no longer know if there will be support for the work that we do, because science and research has…” + 39049
Reposted by Steve KayNature Portfolio @natureportfolio.nature.com · 03/08/2025Unique biological, exposomal, economic and sociocultural factors shape resilience and brain health across the globe. A Review in Nature Medicine discusses underlying mechanisms of resilience. go.nature.com/4l76HNh #medsky 🧪 0256
Steve Kay @drstevekay.bsky.social · 30/07/2025Joanne Chory (1955–2024): Plant geneticist extraordinaire | PNAS www.pnas.org/doi/10.1073/...pnas.orgJoanne Chory (1955–2024): Plant geneticist extraordinaire | PNASJoanne Chory (1955–2024) was a pioneering biologist whose research transformed our understanding of plant growth and development. Her groundbreakin... 140
Reposted by Steve KayDr. Lucky Tran @luckytran.com · 30/07/2025Outrageous. The White House is sidestepping Congress and halting up to $15 billion in NIH research funding, which would have gone to study diabetes, cancer & more. The order was issued through a four-sentence email sent to NIH directors from Office of Management & Budget Director Russell Vought. 43826398
Reposted by Steve KayKelsey J.R.P. Byers @plantpollinator.bsky.social · 28/07/2025. #Botany2025 My institution (JIC in Norwich, UK) is hiring for a tenure-track Group Leader in Discovery Plant Sciences - see more here: www.jic.ac.uk/vacancies/gr... Let me know if you have questions!jic.ac.ukGroup Leader in Discovery Plant Sciences | John Innes CentreThe John Innes Centre (JIC) seeks a visionary Group Leader to lead research on Discovery Plant Science. 12632
Reposted by Steve KayNature @nature.com · 25/07/2025Decreased funding, reduced opportunities and growing uncertainty has made life tough for international postdocs living in the US go.nature.com/4mg4ct9go.nature.comMeet the early career scientists planning to leave the United StatesDecreased funding, reduced opportunities and growing uncertainty has made life tough for international postdocs living in the US. 13213
Reposted by Steve KayEle Willoughby @minouette.bsky.social · 25/07/2025Happy birthday Rosalind Franklin (1920 –1958), #chemist & x-ray crystallographer whose x-ray diffraction images were instrumental to discovering double-helix structure of DNA, made important contributions to carbon & virus research, was 1 of the great scientists of the 20th century. 🧪🐡👩🏼🔬 #histsci 🧵 418159
Reposted by Steve KayMartin Kampmann @kampmann.bsky.social · 23/07/2025Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702 18571
Reposted by Steve KayDrug Monkey @drugmonkey.bsky.social · 24/07/2025"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year" 156
Reposted by Steve KayScience Magazine @science.org · 30/06/2025Hundreds of employees at the EPA released a “Declaration of Dissent” today, accusing EPA officials of politicizing the agency and undermining its core mission to “protect human health and the environment.” scim.ag/4lB937Sscim.agEPA employees accuse Trump officials of undermining the agency’s mission“Declaration of Dissent” denounces partisan messaging, rollback of environmental regulations, and dismantling of science office, among other concerns 215657
Reposted by Steve KayDrug Monkey @drugmonkey.bsky.social · 30/06/2025Where has industry been the past several months? Better late than never I suppose….. 1252
Reposted by Steve KayScott McGrath @smcgrath.phd · 26/06/2025The Trump administration has canceled billions in research grants to Harvard, imperiling critical scientific work. This has prompted the university to seek new funding models and raises questions about the future of US science funding. #AcademicSky 🧪nature.comHarvard vs Trump: what this epic battle means for scienceResearch across science and medicine will probably shrink at one of the world’s most elite universities amid a new political reality. 0109
Reposted by Steve KayCarl Zimmer @carlzimmer.com · 16/06/2025A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOGnyti.msTrump’s Cuts to N.I.H. Grants Are Illegal, Federal Judge RulesThe judge accused the Trump administration of discriminating against minorities and L.G.B.T.Q. people and ordered the government to restore much of the funding. 011846
Reposted by Steve KayBioClocks UK @bioclocksuk.bsky.social · 11/06/2025If you’ve ever travelled across multiple time zones, you may already know a bit about #jetlag. What symptoms do you experience? Check out our full factsheet on Jetlag here: www.bioclocks.uk/factsheets #chronobiology #scicomm 🧪 043
Reposted by Steve KayScience Friday @scifri.bsky.social · 02/06/2025Plant biologist Joanne Chory spent her career trying to grow plants that could sequester CO2 in their roots. Her wild ideas took hold. Learn about her outstanding career and legacy in Ep. 4 of “The Leap" with @hypothesisfund.bsky.social. 🔊 Listen here: buff.ly/yLqDcDL 18914
Reposted by Steve KayProf Sam Illingworth @samillingworth.com · 31/05/2025🧠📉 The 'pivot penalty' in science A new study in @nature.com finds scientists get cited less after switching research fields – the bigger the shift, the steeper the drop. 🔗 doi.org/10.1038/d415... #SciComm #AcademicSky 🧪doi.orgThe ‘pivot penalty’: scientists get cited less after switching fields, analysis findsMassive study of nearly 26 million research papers measures the consequences of striking out in another research area. 43222
Reposted by Steve KayPeter Gleick @petergleick.bsky.social · 31/05/2025There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation. 449151507825
Reposted by Steve KayLiz Neeley @lizneeley.bsky.social · 30/05/2025Furiously logging all the new budget news, laughing grimly that it landed *just after* we hit publish. Of course it did. Grateful that the entire point of @unbreaking.org is to give us a durable platform where we can keep integrating new developments. We'll digest, contextualize & update next week. 312641
Reposted by Steve KaySelma Masri @masrilab.bsky.social · 27/05/2025Super happy to share our latest in @natcancer.nature.com co-led by @pannunziolab.bsky.social! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out! www.nature.com/articles/s43...nature.comThe diverse roles of the circadian clock in cancer - Nature CancerMasri and colleagues review the latest studies on the influence of circadian rhythms in cancer biology, discussing possible connections between chronobiology and cancer prevention and treatment. 1145
Reposted by Steve KayBryan Roth @zenbrainest.bsky.social · 27/05/2025Why are animal models useful for CNS drug discovery? zendudest.substack.com/p/why-animal...zendudest.substack.comWhy animal models are useful for CNS drug discovery: Part 1CNS drug discovery is more successful than oncology!! 12215
Reposted by Steve KayScience Friday @scifri.bsky.social · 16/05/2025Dr. Katalin Karikó spent decades experimenting with mRNA. She was scoffed at, demoted, and eventually forced to retire. Then, she won a Nobel Prize. Her story is the first in our 10-episode series, “The Leap,” produced with the Hypothesis Fund.sciencefriday.comI Was Considered A NobodyKatalin Karikó was ignored, demoted, and dismissed for decades. Then she won a Nobel Prize. 216343
Reposted by Steve KayScience Magazine @science.org · 13/05/2025A new ultrasound-guided #3Dprinting technique could make it possible to fabricate medical implants in vivo and deliver tailored therapies to tissues deep inside the body—all without invasive surgery, researchers report in Science. scim.ag/4dlUh1Yscim.agImaging-guided deep tissue in vivo sound printingThree-dimensional printing offers promise for patient-specific implants and therapies but is often limited by the need for invasive surgical procedures. To address this, we developed an imaging-guided... 06517
Steve Kay @drstevekay.bsky.social · 12/05/2025keck.usc.edu/news/new-com...keck.usc.eduNew compound targets circadian clock machinery in cells to fight glioblastomaRelated News USC team develops a powerful new analytical tool to advance CAR T cell therapy research May 1, 2025 USC Stem Cell’s journey towards 1,000 mini-kidneys begins with $1 […] 041
Reposted by Steve KayScripps Research @scripps.edu · 12/05/2025Using computer modeling, scientists at Scripps Research show how bNAbs recognize HIV by interacting with MPER—a membrane-proximal, hard-to-access region—and surrounding lipids, structures long thought too risky to target, in work published in @elife.bsky.social.ow.lyAntibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments 051
Reposted by Steve KayJosh Fischman @jfischman.bsky.social · 05/05/2025Against measles, do 3 drugs or vitamins that RFK Jr. just said are "good" & "effective" remedies work? Nope, and I explain why in this Scientific American story. Meanwhile the measles outbreak keeps growing. www.scientificamerican.com/article/do-a... 🧪 🩺scientificamerican.comDo ‘Alternative’ Measles Treatments Touted by RFK Jr. Work?As the measles outbreak in the U.S. gets bigger, HHS’s secretary Robert F. Kennedy, Jr., touts nonvaccine treatments. But they generally don’t help and can carry dangers 416769
Reposted by Steve KayKeck School of Medicine of USC @keck.usc.edu · 02/05/2025Innovation in action🔬 🧬 A team of researchers from the Keck School of Medicine has developed an advanced tool for analyzing chimeric antigen receptor (CAR) T cells, paving the way for more precise, effective cancer therapies. #Science #CancerResearch #MedSky keck.usc.edu/news/usc-tea...keck.usc.eduUSC team develops a powerful new analytical tool to advance CAR T cell therapy researchRelated News New USC study shows immigrant adults with liver cancer have higher survival rates than those born in the US May 10, 2023 Study finds new, unexpected mechanism of […] 061
Reposted by Steve KayJudith Su @judithsu.bsky.social · 02/05/2025Glad to share our latest paper on optical biosensors for diagnosing neurodegenerative diseases: www.nature.com/articles/s44... @natureportfolio.nature.com @uazbio5.bsky.socialnature.comOptical biosensors for diagnosing neurodegenerative diseases - npj Biosensingnpj Biosensing - Optical biosensors for diagnosing neurodegenerative diseases 16217
Reposted by Steve KayNature Portfolio @natureportfolio.nature.com · 28/04/2025A Review in Nature Reviews Drug Discovery discusses the implementation of biomarkers in clinical trials across various neurodegenerative disorders, focusing on the context of use, to help expedite and de-risk drug development. go.nature.com/44Fxpb5 🧪 0143
Reposted by Steve KayUSC Viterbi @viterbischool.usc.edu · 23/04/2025Come inside and explore the new Dr. Allen and Charlotte Ginsburg Human-Centered Computational Hall @sac.usc.edu @csatusc.bsky.social click the link to watch the full version: youtu.be/vqR2jYTvXTw 042
Reposted by Steve KayNature Portfolio @natureportfolio.nature.com · 22/04/2025Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪 23511
Reposted by Steve KayNature @nature.com · 22/04/2025"Along with 50 scientists from the SPHERA Consortium, which comprises leading research institutions across the European Union, we have drafted a declaration on the defence of science" go.nature.com/3Exty5ygo.nature.comDefend scientific integrity and academic freedomLetter to the Editor 26422
Reposted by Steve KayIvy L. Xiong @ivyxiong.bsky.social · 16/04/2025My article with @agarfinkel.bsky.social titled "𝗔𝗿𝗲 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗼𝘀𝗰𝗶𝗹𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝙥𝙝𝙮𝙨𝙞𝙤𝙡𝙤𝙜𝙞𝙘𝙖𝙡?" has ranked as a Top Viewed Article by Wiley. Check it out if you haven't done so: onlinelibrary.wiley.com/doi/full/10.... #TopViewedArticleonlinelibrary.wiley.comAre physiological oscillations physiological?Abstract figure legend Mechanisms and functions of physiological oscillations. 172
Reposted by Steve KayAnthony Hall @ajwhall.bsky.social · 15/04/2025I have a PhD project funded by the John Innes Foundation, "Uncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties", from the 1st of October 2025. #wheat #bioinformatics Apply now www.earlham.ac.uk/studentship/...earlham.ac.ukUncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties 088
Reposted by Steve KayJon Cohen @cohenjon.bsky.social · 15/04/2025I'm turning final corner on book in works for 4 years about scientific efforts to prevent future pandemics. Knopf plans to publish in October and now has teaser up. Deeply grateful to @sloanfoundation.bsky.social and many others for the support! www.penguinrandomhouse.com/books/690752...penguinrandomhouse.comPlanning Miracles by Jon Cohen: 9780593321225 | PenguinRandomHouse.com: BooksA groundbreaking book about the past, present, and future of pandemics, and a behind-the-scenes portrait of the intrepid and innovative community of scientists working tirelessly to stop the next one ... 14514
Reposted by Steve KayNature @nature.com · 11/04/2025Threats to US biomedical research grants at the NIH are coming thick and fast — and so are the lawsuits. Here, Nature unpacks the legal claims. go.nature.com/4idgY9dgo.nature.comNIH cuts triggered a host of lawsuits: Nature’s guide to what’s nextA host of legal claims aim to roll back the Trump administration’s grant terminations, indirect-cost cap and more. 17226
Reposted by Steve KayNature @nature.com · 11/04/2025Vaccines have granted families in wealthy countries the luxury of forgetting what measles, polio, rubella, and other preventable diseases are like. We're looking at how many millions of lives vaccines have saved. Read the full story: go.nature.com/4jqOqKn 413149
Reposted by Steve KayCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/04/2025Great article by @nobelprize.bsky.social laureate @ardemp.bskyverified.social outlining the health, economic and national security benefits of US biomedical research, and the devastation of government efforts to destroy our leading edge. www.cnn.com/2025/04/09/h...cnn.comNobel laureate: I owe America my success. Today, its scientific future is in danger | CNNDr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted... 211549
Reposted by Steve KayNature @nature.com · 09/04/2025Studies of researchers globally suggest there is a mental-health crisis in academia go.nature.com/3RNAbmZgo.nature.comA mental-health crisis plagues PhDs — these evidence-led initiatives offer helpCommunities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics. 16025
Reposted by Steve KayMargot Finn @eicathomefinn.bsky.social · 09/04/2025'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'timeshighereducation.comX’s dominance ‘over’ as Bluesky becomes new hub for researchData indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover 129174274385
Reposted by Steve KayNature Portfolio @natureportfolio.nature.com · 09/04/2025Public-health specialists worry that misinformation and funding cuts could affect vaccination rates. To illustrate the impact of vaccines, Nature examines the millions of lives that they have saved through these five charts. #medsky 🧪 go.nature.com154 million lives and counting: 5 charts reveal the power of vaccinesBut public-health specialists worry that misinformation and funding cuts could affect vaccination rates. 01610
