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Emily Edwards

@dremmye.bsky.social
456 followers 126 following 39 posts

British-Australian Immunologist, Rare Diseases Researcher at Monash Uni and patient advocate (AusPIPS), interested in genetics and its role in impairing immune function in #primaryimmunodeficiencies, towards improved diagnosis and treatment #Immunology

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Emily Edwards @dremmye.bsky.social · 23/07/2026
Excited to share that my abstract was accepted to #ESID2026 in #Maastricht! Looking forward to sharing my research, exchanging ideas, and learning about the latest developments in #IEI. Join us before 13 July to enjoy the best rates! 👉 invt.io/1bxbenkmqdq
invt.io
I will present my research at ESID 2026, join me
Register today and save!
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Journal of Human Immunity @jhumimmunity.org · 04/05/2026
In a new study from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...
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Emily Edwards @dremmye.bsky.social · 16/04/2026
Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies. authors.elsevier.com/a/1mwz8Ks2xP...
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Emily Edwards @dremmye.bsky.social · 16/04/2026
Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies. authors.elsevier.com/a/1mwz8Ks2xP...
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All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
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Waggoner Lab @labwaggoner.bsky.social · 13/02/2026
Congrats Todd & team @bruskolab.bsky.social Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles www.science.org/doi/10.1126/...
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Waggoner Lab @labwaggoner.bsky.social · 06/12/2025
Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation @natcomms.nature.com www.nature.com/articles/s41...
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Waggoner Lab @labwaggoner.bsky.social · 29/11/2025
One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)
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Waggoner Lab @labwaggoner.bsky.social · 26/11/2025
We are all mosaics: vast genetic diversity found between cells in a single person @nature.com www.nature.com/articles/d41... @biorxivpreprint.bsky.social ⁦@mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social www.biorxiv.org/content/10.1...
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 22/11/2025
Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence www.biorxiv.org/content/10.1101/202…
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Casanova Lab @casanovalab.bsky.social · 20/11/2025
A PIK3delta inhibitor for ALPS: Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
rupress.org
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome | Journal of Human Immunity | Rockefeller University Press
Treating patients with ALPS can be challenging. This article examines the efficacy of leniolisib, a selective PI3Kδ inhibitor, in a murine model of ALPS, i
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medRxivpreprint @medrxivpreprint.bsky.social · 18/11/2025
Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition www.medrxiv.org/content/10.1101/202…
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medRxivpreprint @medrxivpreprint.bsky.social · 18/11/2025
Predicting long-term waning of anti-spike antibody-dependent protection against COVID-19 across diverse SARS-CoV-2 immune histories www.medrxiv.org/content/10.1101/202…
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medRxivpreprint @medrxivpreprint.bsky.social · 18/11/2025
Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: a prospective cohort study www.medrxiv.org/content/10.1101/202…
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Journal of Experimental Medicine @jem.org · 16/11/2025
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/... 📘 In #Neuroscience 2025: rupress.org/jem/collecti... #SfN25
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Christoph Bock Lab @ CeMM & MedUni Vienna @bocklab.bsky.social · 11/11/2025
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
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Emily Edwards @dremmye.bsky.social · 14/11/2025
Proud to share our new preprint revealing how patients with inborn errors of immunity respond to 3 doses of COVID-19 vaccination. A fantastic collaboration between clinicians & scientists. Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC medrxiv.org/cgi/content/...
medrxiv.org
Third dose COVID-19 vaccination elicits immune memory in patients with inborn errors of immunity even in absence of neutralizing antibodies
Background: Immunocompromised people, including those with Inborn Errors of Immunity (IEI), are at increased risk of severe disease from viral infections. Therefore, regular booster vaccinations are r...
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Waggoner Lab @labwaggoner.bsky.social · 23/10/2025
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes @science.org @shaleklab.bsky.social www.science.org/doi/10.1126/...
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Emily Edwards @dremmye.bsky.social · 22/10/2025
I’m excited to share our newly published paper. Only the second report of Spleen Tyrosine Kinase (SYK) gain-of-function. We detail the clinical, immunological, and genetic features of an adult with primary immunodeficiency and autoinflammation in the Journal of Clinical Immunology: 🔗 rdcu.be/eLWFr
rdcu.be
Novel SYK Variant Causes Enhanced SYK Autophosphorylation and PI3K Activation in an Antibody-Deficient Patient
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Emily Edwards @dremmye.bsky.social · 17/09/2025
Proud to be talking at this webinar on the 8th of October alongside Ig therapy manufacturers, patients receiving therapy, clinicians and SCIg nurses. #patientawareness
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Nature Reviews Rheumatology @natrevrheum.nature.com · 01/09/2025
New content online:
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Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
Nature Reviews Rheumatology, Published online: 01 September 2025; doi:10.1038/s41584-025-01291-0In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.
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Waggoner Lab @labwaggoner.bsky.social · 03/09/2025
Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk @medrxivpreprint.bsky.social @anglixue.bsky.social @drjosephpowell.bsky.social www.medrxiv.org/content/10.1...
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 24/08/2025
Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications www.biorxiv.org/content/10.1101/202…
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Emily Edwards @dremmye.bsky.social · 15/08/2025
From lab bench to Parliament House, a few weeks ago, I was proud to bring the voices of patient advocacy and rare disease research to advocate for equitable and fair access to vaccination and blood products. With this dual lens, I added evidence-based insights to strengthen the case for change.
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Klaus Okkenhaug @klausokken.bsky.social · 28/07/2025
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
science.org
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...
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Waggoner Lab @labwaggoner.bsky.social · 03/07/2025
Scalable screening of ternary-code DNA methylation dynamics associated with human traits www.cell.com/cell-genomic...
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 27/06/2025
Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes www.biorxiv.org/content/10.1101/202…
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Emily Edwards @dremmye.bsky.social · 28/06/2025
An excellent preprint offering valuable insights into the impact of CMV infection on the immune system. Three insights are important as CMV is a herpesvirus, to which over 70% of the population has been exposed.
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Journal of Human Immunity @jhumimmunity.org · 23/06/2025
Topical JAK inhibitor for refractory skin #inflammation in STAT1 GOF. New report from Valentina Guarnieri, Tiphaine Arlabosse, Claire Booth, and Gabriela Petrof @greatormondst.bsky.social: rupress.org/jhi/article/... #Therapeutics #InbornErrorsOfImmunity
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UCL Dept of Aging, Rheumatology & Regenerative Medicine @arrdept-ucldom.bsky.social · 18/06/2025
So fabulous to see this paper out! Prof Lucy Wedderburn is a close collaborator of many researchers in our dept and this paper makes an important contribution to continued efforts to understand better ways to predict treatment response in patients with autoimmune conditions 🧬 read more below 👇
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Emily Edwards @dremmye.bsky.social · 18/06/2025
Proud to be a recipient of a seed grant from the Victorian Critical Vaccinees Collection, to investigate memory B cells in elderly individuals receiving the COVID-19 vaccine, and finding parallels with responses in immunocompromised lnkd.in/g2FxQX5q @MonashSTM @ErasmusMC
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Emily Edwards @dremmye.bsky.social · 09/05/2025
I would like to share our pre-print in medRxiv. Here, we describe a novel monoallelic missense variant (c.1769G>A; p.R590Q) in the spleen tyrosine kinase (SYK) gene causing SYK gain-of-function (GOF). A collaboration between Monash Uni, Alfred Health, Erasmus MC. www.medrxiv.org/content/10.1...
doi.org
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Emily Edwards @dremmye.bsky.social · 30/04/2025
This years visit to raise awarenss of Primary Immunodeficiencies as part of World Primary Immunodeficiencies Week. Thanks @DrShaneRRR for having us every year. Einstein A Go-Go – www.rrr.org.au/shared/broad... via @3RRRFM @MonashImmunol @MonashSTM
rrr.org.au
Shared moment from Einstein A Go-Go – 27 April 2025 — Triple R 102.7FM, Melbourne Independent Radio
An episode of Einstein A Go-Go on 27 April 2025
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Emily Edwards @dremmye.bsky.social · 25/04/2025
I'm proud to announce my promotion to Group Leader of the Primary Immunodeficiencies Group part of the Allergy and Clinical Immunology Lab in Dept Immunology, School of Translational Medicine @monashuniversity.bsky.social. We're working towards precision diagnosis & targeted treatment for patients
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Waggoner Lab @labwaggoner.bsky.social · 02/04/2025
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic www.cell.com/cell-reports... @cp-cellreports.bsky.social @gmoncure.bsky.social
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Waggoner Lab @labwaggoner.bsky.social · 28/03/2025
An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment www.cell.com/cell-genomic...
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Waggoner Lab @labwaggoner.bsky.social · 21/03/2025
High-throughput screening of human genetic variants by pooled prime editing www.cell.com/cell-genomic...
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Wendy Bickmore @wbickmor.bsky.social · 21/03/2025
Unpicking non-coding genetic variation: Structure-guided modelling holds promise for evaluating how single nucleotide variants affect transcription factor binding. www.biorxiv.org/content/10.1.... @uoe-igc.bsky.social
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Emily Edwards @dremmye.bsky.social · 03/03/2025
Useful resources
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Alicia Oshlack @aliciao.bsky.social · 01/03/2025
Pleased to present our CITE-seq paper analysing 45 BAL samples from (un)treated children with CF and controls. BAL is a tricky tissue, 44 celltypes dominated by macrophages. Trailblazing analysis led by @jovmaksimovic.bsky.social @melanieneeland.bsky.social @shivanthans.bsky.social and collaborators
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Seth Thomas Scanlon @immunoeditor.bsky.social · 28/02/2025
To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org
The February 2024 cover of Science Immunology depicts CRISPR–Cas9–mediated repair of a dysfunctional cytotoxic T cell (red) from an individual with familial hemophagocytic lymphohistiocytosis (FHL), which allows it to secrete normal cytotoxic granules (pink) and effectively kill virally infected B cells (blue). (Credit: A. Fisher/Science Immunology)
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Emily Edwards @dremmye.bsky.social · 28/02/2025
It was my pleasure to co-host this webinar with the Immune Deficiency Foundations Carolyn Dewes. #RareDiseaseDay2025 #inbornerrorsofimmunity @monashuniversity.bsky.social @monashstm-grsc.bsky.social
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 22/02/2025
JAK inhibitors remove innate immune barriers to allow viral propagation www.biorxiv.org/content/10.1101/202…
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 21/02/2025
Characterisation of CD4 Th subsets as well as dietary, exercise and lifestyle factors in an established Rheumatoid Arthritis cohort; pilot study. www.biorxiv.org/content/10.1101/202…
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 16/02/2025
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade www.biorxiv.org/content/10.1101/202…
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Clinical Infectious Diseases @cidjournal.bsky.social · 08/02/2025
Long-COVID incidence proportion in adults and children between 2020 and 2024 ✅ Just Accepted #IDSky
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Long-COVID incidence proportion in adults and children between 2020 and 2024
Incidence estimates of post-acute sequelae of SARS-CoV-2 infection, also known as long-COVID, have varied across studies and changed over time.
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Emily Edwards @dremmye.bsky.social · 06/02/2025
Thanks @immunolcellbiol.bsky.social for inviting Menno and I to write this commentary about the @bogunoviclab.bsky.social paper in @nature.com on monoallelic allele expression in inborn errors of immunity Monash Immunology and Erasmus MC #immunosky doi.org/10.1111/imcb...
doi.org
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Waggoner Lab @labwaggoner.bsky.social · 29/01/2025
SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses www.science.org/doi/10.1126/... @blishlab.bsky.social
science.org
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection
SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses.
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Tom Kindlon @tomkindlon.bsky.social · 24/01/2025
New press release: "Long COVID, Italian scientists discovered the molecular ‘fingerprint’ of the condition in children's blood" - led by @buonsenso.bsky.social www.eurekalert.org/news-release... #LongCovid #LongCovidKids #LCKids
News Release 24-Jan-2025
Long COVID, Italian scientists discovered the molecular ‘fingerprint’ of the condition in children's blood
Peer-Reviewed Publication
Universita Cattolica del Sacro Cuore

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One day Long Covid in children could be objectively diagnosed with a blood test, thanks to the help of Artificial Intelligence (AI). In fact, a study by the Università Cattolica del Sacro Cuore, Rome campus - Fondazione Policlinico Universitario Agostino Gemelli IRCCS and the Ospedale Pediatrico Bambino Gesù IRCCS, has highlighted the molecular signature of Long Covid in plasma in paediatric age and used an AI tool capable of making the diagnosis based on the results of the blood sample, with 93% accuracy.

The study was published in the journal ‘Pediatric Research’, by Nature Group, and was led by Dr. Danilo Buonsenso, researcher in general and specialist paediatrics at the Faculty of Medicine and Surgery of the Catholic University and paediatrician at the Pediatric Infectious Diseases Operative Unit of the Fondazione Policlinico Gemelli IRCCS, together with Dr. Nicola Cotugno, at the Complex Operative Unit of Clinical Immunology and Vaccinology of the Bambino Gesù IRCCS Paediatric Hospital.
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Emily Edwards @dremmye.bsky.social · 23/01/2025
Nice paper showing the utility of functional assays to understand the mechanisms driving rheumatoid arthritis.
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