Nguyen et al. show that the splenic environment provides sequential signals via lymphotoxin and retinoic acid that guide cDC2A development and retention.

Mucosal IgA is key in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Several mucosal vaccines are in development,…

Marion Gommerman is heading back to class in Toronto this fall, with a goal to finish post-secondary studies she began decades ago.

Marion Gommerman isn’t sure where her lifelong love of learning came from, but at 82 years old, she’s leaning into it. This fall, Gommerman will be among those heading back to class and hitting the bo...

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

As the NIH braces for cuts of up to 5,000 of its 20,000 positions, “people are scrambling and freaking out,” a researcher said.

Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...

Move to cut indirect cost rate to 15% could cost universities billions of dollars

Although IgA+ long-lived plasma cells (LLPCs) generated following mucosal viral infection provide durable protection against reinfection, little is known about their generation. Here, we show that ora...

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.