iiinova — where your digital self keeps evolving

Reposted by Sean Fanning

Nelson Lab, UIUC @nelsonlab.bsky.social · 24/03/2026

Register now for an amazing menu of endocine-related science and clinical practice! Early bird rate is ending soon! #ENDO2026

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Sean Fanning @docfanning.bsky.social · 21/03/2026

@cbartman.bsky.social I saw your post about Cas9 cells. Happy to share our MCF7 cas9 cells and gRNA protocol if you send a FedEx label for dry ice shipping.

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Reposted by Sean Fanning

Stephan Hacker @stephanhacker2.bsky.social · 19/03/2026

How do hormones and diet influence the outcome of #cancer therapy? Wilbert Zwart (@zwartlab.bsky.social) of the @nkinl.bsky.social gave an amazing lecture on this topic at #KNCVMCCB2026 covering various strategies to use this information for improved treatments. www.nature.com/articles/s41...

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Reposted by Sean Fanning

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 14/03/2026

Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling www.biorxiv.org/content/10.64898/20…

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Reposted by Sean Fanning

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 16/05/2025

🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/...

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Reposted by Sean Fanning

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 07/06/2025

📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site

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Reposted by Sean Fanning

Matt Sikora @mjsikora.bsky.social · 14/11/2025

grants.nih.gov/grants/guide... This is going to be a fun next few grant cycles....

As of today, we can confirm that we will be rescheduling all October and November grant application submission deadlines (specific dates to be announced in a future Notice). By delaying due dates that occurred both during the lapse in funding and in the week following, applicants will have access to NIH staff and the help desks as they develop their applications.

Peer review meetings that were scheduled to take place between October 1 and November 14 have been cancelled and will be rescheduled, details to come. Additionally, council meetings that were scheduled to take place between October 1 and November 14 were cancelled and will be rescheduled, details to come.

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Reposted by Sean Fanning

Biochemistry & Molecular Biomedicine UB @bqbiomedmolub.bsky.social · 22/10/2025

🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá ‪@estebanezlab.bsky.social ‬@ibub-ub.bsky.social @biologiaub.bsky.social Enhorabona! 👋👋

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Reposted by Sean Fanning

Matt Sikora @mjsikora.bsky.social · 20/10/2025

I know & trust that NIH staff will get this round of reviews done. Yet having done my own CSR reviews 'for nothing' & with my own R01 sitting unreviewed now, working on another NIH grant has never felt so painful and futile. A quiet impact on science, perhaps, robbing the joy from looking ahead.

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Reposted by Sean Fanning

Governor JB Pritzker @govpritzker.illinois.gov · 19/10/2025

Democracy in action, Illinois. Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.

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Sean Fanning @docfanning.bsky.social · 11/09/2025

Just wrapped up my medical school teaching for the year. I happened to have an exceptionally awesome group of M1s. I’m excited to see where they’ll go from here!

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Reposted by Sean Fanning

Senator Bernie Sanders @sanders.senate.gov · 02/09/2025

RFK Jr. and Trump tell us they want to Make America Healthy Again. Great slogan. I agree. Unfortunately, they are doing the exact opposite. Vaccines work. They are safe. They save lives. No more conspiracy theories. Kennedy must resign.

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Sean Fanning @docfanning.bsky.social · 28/08/2025

Fanning Lab BBQ 2025! Another good year in the books thanks to this exceptional group! Also, they wanted me to make ribs and brisket, they know I look for any excuse to do a cook.

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Sean Fanning @docfanning.bsky.social · 16/07/2025

I had a wonderful time at Endo2025, catching up with great colleagues doing fantastic and important work in endocrinology. I particularly enjoyed chairing the session on Nuclear Receptor Structural Biology where @dougkojetin.bsky.social gave a powerhouse performance! 1/3

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Matt Sikora @mjsikora.bsky.social · 10/07/2025

New review from us on radiation in #lobular breast cancer! www.nature.com/articles/s41... Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data? led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n

nature.com

Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity - npj Breast Cancer

npj Breast Cancer - Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity

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Reposted by Sean Fanning

Bryan Welm @bryanwelm.bsky.social · 10/07/2025

Finished another bronze of a T-cell attacking a cancer cell. This one is heading to Max Krummel at UCSF, who did some of the early studies on CTLA4 immunotherapy. #sciart.

Bronze sculpture of a T-cell attacking a cancer cell.

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Sean Fanning @docfanning.bsky.social · 27/06/2025

Very proud of Sofia for successfully defending her Master’s thesis today!! She’s starting her PhD in biomedicine at UMiami next year. Can’t wait to see what she’ll accomplish! I’m a proud PI!

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Reposted by Sean Fanning

Matt Sikora @mjsikora.bsky.social · 25/06/2025

We did a thing w @jostrander.bsky.social! Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n

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Reposted by Sean Fanning

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 23/06/2025

CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells www.biorxiv.org/content/10.1101/202…

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Reposted by Sean Fanning

Tammy Duckworth @duckworth.senate.gov · 22/06/2025

Trump bombing Iran was illegal and unjustified. I ran for Congress to make sure our leaders consider the true costs of war. And I will be in the Senate, standing on my titanium legs, demanding answers from Trump. My statement:

Duckworth statement on Trump’s strikes against Iran nuclear sites.

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Reposted by Sean Fanning

Science News @scinews.bsky.social · 22/06/2025

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM "zimislecel can restore physiologic islet function" Reference www.nejm.org/doi/full/10....

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Reposted by Sean Fanning

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 21/06/2025

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity www.biorxiv.org/content/10.1101/202…

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Reposted by Sean Fanning

Nima Sharifi MD @nimasharifimd.bsky.social · 21/06/2025

Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext

jbc.org

HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer

Endocrine resistance is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancer, often leading to disease recurrence and metastasis. 3β-Hydroxysteroid dehydrogenase 1 (3βH...

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Reposted by Sean Fanning

Rep. Jamie Raskin @raskin.house.gov · 17/06/2025

Today I’m leading 152 House Democrats in challenging Trump's devastating cuts to life-saving NIH research grants. Congress—not Trump—controls federal spending. Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.

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Reposted by Sean Fanning

CU Gynecologic Oncology Research @cugynonc.bsky.social · 17/06/2025

Congrats to Team Bitler—Drs. Bitler, Corr, Sikora, Clauset, and many others—2025 CU ASPIRE Awardees🎉Their SPORE effort to advance ovarian cancer care with novel therapies & population science. #OvarianCancer #CUAnschutz @uccc-gorg.bsky.social‬ @mjsikora.bsky.social View details here: Bit.ly/4mWBRsO

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Reposted by Sean Fanning

Governor JB Pritzker @govpritzker.illinois.gov · 16/06/2025

The Illinois General Assembly and I are working to make life more affordable for working families. Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.

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Reposted by Sean Fanning

ACLU @aclu.org · 16/06/2025

BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity. This is a major win for public health.

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Reposted by Sean Fanning

Ernst Schmid @ernstschmid.bsky.social · 28/05/2025

Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu and read about it here-> www.nature.com/articles/s41...

nature.com

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

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Reposted by Sean Fanning

eLife @elife.bsky.social · 29/05/2025

🧪 A new method called MagIC-Cryo-EM allows scientists to use powerful #CryoEM techniques to examine proteins that have been difficult to study so far.

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The (molecular) shape of you

New methods allow scientists to use a powerful technique known as cryo-EM to examine proteins that have been difficult to study so far.

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Sean Fanning @docfanning.bsky.social · 09/05/2025

Congratulations to Sofia for graduating with her Masters degree! She the first Masters student to graduate from our lab! She did an impressive amount of work studying our new antiestrogens in breast cancer! She’s starting her PhD studies at UMiami in the fall, keep an eye on this rising star!

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Sean Fanning @docfanning.bsky.social · 30/04/2025

Come see @govindah.bsky.social present his awesome work showing how induction of SUMO1 expression contributes to the anti-cancer efficacy of fulvestrant in breast cancer! Despite decades of study, we still know remarkably little on how endocrine therapies work!

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Reposted by Sean Fanning

Craig M. Crews @craigmcrews.bsky.social · 28/04/2025

"The half-life of this administration is two years; the half-life of the damage to American competitiveness is probably measured in decades." www.nytimes.com/2025/04/28/o...

nytimes.com

Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing

Underlying many investments are breakthroughs in medicine and technology from great universities.

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Reposted by Sean Fanning

60 Minutes @60minutes.bsky.social · 28/04/2025

Nearly 800 NIH grants have been terminated so far, including some focused on HIV and AIDS, trans health, and COVID-19, after researchers were told their work was no longer an agency priority. cbsn.ws/3YkDndI

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Sam Bagenstos @sbagen.bsky.social · 28/04/2025

"Given Kennedy's support for the gutting of the NIH, CDC, and FDA, alongside his espousal of unscientific treatments and theories, The Lancet joins Benjamin's call for Kennedy's resignation." www.thelancet.com/journals/lan....

thelancet.com

Supporting medical science in the USA

The pursuit of rigorous medical science is not compatible with capitulation to government demands aimed at weaponising and eroding science. On April 14, Edwin R Martin Jr, the Trump-appointed interim ...

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Sean Fanning @docfanning.bsky.social · 28/04/2025

Come see Kristen Young present her poster at 9:00 this morning! She shows how inhibiting immunosuppressive paracrine signaling with an antiestrogen reinvigorates NK cells to improve anticancer activities in ER+ breast cancer cells! @kristen-young.bsky.social #AACR25

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Reposted by Sean Fanning

Matt Sikora @mjsikora.bsky.social · 26/04/2025

Made it to AACR! This is my 20 year anniv of membership, w/ my first meeting in 2005 as an undergrad Bardos Scholar. On Monday I'll be speaking in #lobular breast cancer session - eppro02.ativ.me/appinfo.php?... Kicking off #AACR25 on the cancer disparities track! @theaacr.bsky.social

Matt in front of the cover slide reading 'Social determinants of health and cancer outcomes: from the sidewalk to the bench and back again".

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Reposted by Sean Fanning

Stand Up for Science! @standupforscience.net · 01/03/2025

"When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about sickle cell disease being cured because of CRISPR gene editing, that was built on years of research supported by NIH" apnews.com/article/nih-...

apnews.com

Renowned geneticist Francis Collins retires from NIH, urging 'respect' for embattled workers

Dr. Francis Collins, a renowned geneticist, and former longtime director of the National Institutes of Health, is retiring from the government agency and urging “respect” for its embattled workers.

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The New York Times @nytimes.com · 06/03/2025

Breaking News: A federal judge extended his block on President Trump’s efforts to withhold billions in congressionally approved funds from states and said the White House put itself “above Congress.”

nytimes.com

Judge Blocks Trump’s Funding Freeze, Saying White House Put Itself ‘Above Congress’

The judge had ruled that the administration was not complying with his previous order requiring the government to keep disbursing money to states.

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Julie Ostrander @jostrander.bsky.social · 06/03/2025

@docfanning.bsky.social at UMN today telling us about his work on ER structure and Dickkopf-1. My personal favorite was the cameo appearance of PELP1. Great talk Sean!

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Sean Fanning @docfanning.bsky.social · 27/02/2025

More highlights from the Cancer Research night. Emma presenting the latest on estrogen receptor structural ensembles. Followed by Sofia presenting her poster for ants.

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Sean Fanning @docfanning.bsky.social · 26/02/2025

@kristen-young.bsky.social presenting her award winning presentation at the Cardinal Bernardin Cancer Research night!

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Reposted by Sean Fanning

Rick Huganir @rhuganir.bsky.social · 15/02/2025

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

time.com

Experts Call NIH Budget Cuts an 'Apocalypse' for Science

The reductions target indirect costs that cover administrative and equipment costs.

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Nature Portfolio @natureportfolio.nature.com · 16/02/2025

“But despair is not an option,” writes Gretchen Goldman in Nature. “It is important to remember that notable gains have been made in federal scientific-integrity protections in the past two decades.” 🧪

go.nature.com

‘Despair is not an option’ — how scientists can help protect federal research

Government scientists in the US must be clear-eyed and continue to serve the public.

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