AbstractBackground:. The HSD3B1 gene encodes an androgen synthesis enzyme critical for prostate cancer (PCa) progression. The CC genotype of a common missense variant in HSD3B1 (rs1047303) is consider...

Metabolites, beyond their canonical roles in energy production and biosynthesis, also serve as precursors for a diverse array of post-translational modifications (PTMs). The functional significance of...

A study dissects the way in which fasting or a fasting-mimicking diet augments the effect of hormonal therapy in a mouse model of breast cancer.

Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e

Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.

An official journal of the Endocrine Society. Publishes novel research and mechanistic studies on regulation of receptor/hormone signals, gene expression, development, function, and disease at the mol...

Desai Sethi Urology Institute's Dr. Nima Sharifi and Dr. Zhipeng Wang were named recipients of Prostate Cancer Foundation grants.

Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e

Introduction Using serum metabolomics in Community-Based Participatory Research (CBPR) with underserved populations presents challenges due to the invasive nature of venipuncture, which limits longi...

Apply for Research Associate 1 job with University of Miami in Miami, Florida, United States of America. Research at University of Miami

Official website for the University of Miami Leonard M. Miller School of Medicine

Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

When a pediatrician caring for patients with a rare genetic disease discovers incidentally that he carries his own rare high-risk mutation, he must learn from a patient’s parents how to shift his p...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

prostate cancer, HSD3B1 Genotype, Influence of HSD3B1 Genotype on Prostate Cancer Outcomes Following Definitive Radiation Therapy with ADT.

The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.

Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

Welcome to ‘Cancer Clear and Simple,’ the podcast dedicated to simplifying cancer. Join us as we discuss the world of cancer, breaking down complex concepts for our listening audience. One of our goal...