The lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of mac...

YouTube video by American Thoracic Society

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle,...

imageimagePoorly energized mitochondria trap a subpopulation of mitochondrial precursor proteins in the intermembrane space. This article introduces ‘mitochondrial triage of precursor proteins’ (MitoT...

During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated macrophages (NAMs) in mitigating SARS-CoV-2 pathogenesis. NAMs regulate viral spread and inflammation through type I interferon signaling, revealing their critical function in disease tolerance and potential as therapeutic targets for respiratory viral infections.

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.