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Diego Safian

@diegosafian.bsky.social
156 followers 319 following 3 posts

EvoDevo biologist studying organ evolution at @crick.ac.uk. 🇨🇱 → 🇳🇱 → 🇬🇧 diegosafian.weebly.com

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Reposted by Diego Safian
Ferdinand Marlétaz @ferdix.bsky.social · 11h
Applications open for the TREE NERC DTP in London www.trees-dla.ac.uk/news/we-are-... We have a cool PhD project on echinoderm fossils and genome architecture evolutions with @imranrahman.bsky.social Feel free to drop a line to inquire!
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Will Ratcliff @wcratcliff.bsky.social · 07/10/2026
Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.
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monteirolab.bsky.social @monteirolab.bsky.social · 04/10/2026
Looking for a PhD student to help uncover whether our arms and legs, and those of insects, share the same core gene-regulatory network. If interested, please contact antonia.monteiro@nus.edu.sg. Graduate Program application deadline is 15 Nov 2026 (www.dbs.nus.edu.sg/education/gr...)
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Braasch Lab @ Michigan State University @fishevodevogeno.bsky.social · 28/09/2026
#fish 🐟 🐠 researchers and PIs of tomorrow! We like to sponsor you for an Ecology, Evolution and Behavior (EEB) Presidential #Postdoc Fellowship application @michiganstateu.bsky.social. Applications due Nov 1, so get in touch soom! #EndlessFishMostBeautiful www.fishevodevogeno.org Pls repost!
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Marco Trizzino @marcotrizzino.bsky.social · 25/09/2026
Check the latest preprint from my group!
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James Briscoe @jamesbriscoe.bsky.social · 22/09/2026
Our latest paper on building models of cell fate decisions -with David Rand, Marine Fontaine & @joadelas.bsky.social- combines developmental biology, dynamical systems theory and bioinformatics. I wrote a short piece to summarise it & explain ideas behind the approach briscoelab.org/blog-quantif...
briscoelab.org
Quantifying Waddington's Landscape | Briscoe Lab
I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...
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Vikram Chandra @vchandra.bsky.social · 09/09/2026
I am excited to announce that I will start the Brain Origins Lab at the Crick in March 2027! Using acoels as a model system, the lab will study how animal brains evolve, and how innovations in brain organisation enable new computational abilities and the evolution of complex behaviour.
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Erik van Nimwegen @erikvannimwegen.bsky.social · 09/05/2025
Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...
biorxiv.org
Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data
Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...
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Alfonso Martinez Arias @amartinezarias.bsky.social · 12/09/2026
It is clear that people are using AI to review papers and grants. Often as a tool, not as an off the bottle answer for review (though some do). One of the signs of this is the detail of the negative comments and the errors, often minor and irrelevant to the conclusions. 🧵
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Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Torsten Dikow @tdikow.bsky.social · 10/09/2026
How did I not know about iChatBio? ichatbio.org - an AI-assisted collection data query chat presented at SPNHC by Michael Elliot - virtual.oxfordabstracts.com/event/76295/...
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Will Ratcliff @wcratcliff.bsky.social · 01/09/2026
Four billion years ago, Earth was a sterile rock. Today it is teeming with life, from simple microbes to extraordinarily complex societies that span the globe. How does that happen? I'm writing a book about the answer: Life Unbounded, from Quanta Books. www.quantabooks.org/books/life-u...
quantabooks.org
Life Unbounded
In LIFE UNBOUNDED, pioneering evolutionary biologist William C. Ratcliff reveals that every great leap in life’s complexity, from the first cells to human culture, was driven by the same underlying pr...
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Kaessmann Lab @kaessmannlab.bsky.social · 31/08/2026
We’re hiring! Experimental #Postdoc and computational and/or experimental #PhD positions in evolutionary genomics are available in our lab in Heidelberg: home.kaessmannlab.org/openPositions Please repost and spread the word!
home.kaessmannlab.org
Kaessmann Lab
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Nicolas Di-Poi @nicolasdipoi.bsky.social · 31/08/2026
Ever wondered why snake embryos coil?🐍 A beautifully simple question with a fascinating answer: a growth mismatch between body & gut shapes the coil Our study from @helsinki-biotech.bsky.social @helsinki.fi with T. Miyashita & R.E. Diaz in @currentbiology.bsky.social www.cell.com/current-biol...
cell.com
How snake embryos coil
Snake embryos coil, but how and why they corkscrew remains unexplored. Weber et al. find that the embryos wind up clockwise via buckling of the rapidly elongating axial body against the slow-growing, ...
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PLOS Biology @plosbiology.org · 25/08/2026
What are the genetic mechanisms for the #evolution of novel traits? This study by @brhopkins92.bsky.social &co links #Drosophila sex comb teeth to expression changes within ancestral cells, leading to diverged metabolic/developmental rates, and a novel structure. 🧪 #AcademicSky plos.io/4gQOnZK
Graphical abstract on the gain of a novel trait in Drosophila. The teeth of the recently evolved, male-specific Drosophila sex comb evolved from a more ancient organ, the mechanosensory bristle. We show that changes in the expression of genes that are shared between mechanosensory bristle and sex comb teeth cells lead to changes in a variety of fundamental cellular processes that together enable the morphological transformation.

The photo, phylogeny, general design are those of the corresponding author(s). They made the bristle schematics in biorender and the fly silhouette is their modified drawing of D. melanogaster from SciDraw (https://doi.org/10.5281/zenodo.3925939).
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Erik van Nimwegen @erikvannimwegen.bsky.social · 27/08/2026
Want to explore and understand the structure of your single-cell omics or other high-dimensional data? Try Bonsai! www.nature.com/articles/s41... Check out our tutorial videos with 1. Highlights of the Bonsai-scout exploratory analysis tool: www.youtube.com/watch?v=TE7T...
youtube.com
Bonsai-scout: Highlights
YouTube video by ISMARA: inferring gene regulatory interactions
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Casey Dunn @caseywdunn.bsky.social · 25/08/2026
My new book, Phylogenetic Biology, is now published. Available online for free at dunnlab.org/phylogenetic... . Physical copies can be purchased at shop.lightningsource.com/b/085?params... or your favorite bookstore.
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Fredrik Jutfelt 🐠 @jutfelt.bsky.social · 24/08/2026
Come join us, PhD and postdoc positions! Please spread! Supervisor @patricepottier.bsky.social (patricepottierlab.com), me as co-supervisor. Impacts of climate change on different life-stages in fish.🐟🧪 PhD web103.reachmee.com/ext/I005/103... Postdoc web103.reachmee.com/ext/I005/103...
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Yaniv Elkouby @yanivelkouby.bsky.social · 23/08/2026
Happy to share a new protocol for ex vivo #zebrafish #ovary culture from Amal Shawahny and Yoel Bogoch! Protocol for culture of zebrafish developing ovaries as an ex vivo system for investigating early oogenesis and ovarian development: STAR Protocols www.cell.com/star-protoco...
cell.com
Protocol for culture of zebrafish developing ovaries as an ex vivo system for investigating early oogenesis and ovarian development
A fundamental understanding of early oogenesis is lacking, and zebrafish serve as an excellent model for investigation, based largely on in vivo approaches. We present a protocol for long-term zebrafi...
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Alex de Mendoza @alexdemendoza.bsky.social · 06/08/2026
The #LondonEvoDevo goes to Cambridge! Kindly hosted by @emiliapsantos.bsky.social, mark on your calendars *October 2nd* at the Main Theatre in the Department of Zoology (Cambridge). Registration (£0.00): docs.google.com/forms/d/e/1F.... All welcome to present: #PI #PhD #PostDocs, submit abstracts!
docs.google.com
LondonEvoDevo meeting - October 2026
This event will take place on Friday October 2nd, 2026, at the Department of Zoology (Main Lecture Theatre), University of Cambridge, Downing Street CB2 3EJ, 12:30 - 18:30. There will be no posters, ...
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Alex de Mendoza @alexdemendoza.bsky.social · 03/08/2026
Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵
the indo-pacific bluebottle (Physalia utriculus)
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Emília Santos @emiliapsantos.bsky.social · 14/07/2026
🎨 job alert 🐠 Come join us! We have two positions open! These are part of our @erc.europa.eu funded project on the mechanisms underpinning convergence of colour patterns in cichlid fishes! Closing date: 16th August. Postdoc: www.cam.ac.uk/jobs/researc... Technician: www.cam.ac.uk/jobs/researc...
static.klipy.com
Callipterus Cichlid Collecting Shell
ALT: Callipterus Cichlid Collecting Shell
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Darío Lupiáñez @dariloops.bsky.social · 21/07/2026
🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs
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Xavier Grau-Bové 🌾 @xgrau.bsky.social · 20/07/2026
I'm happy to share our latest on #coral single-cell biology: a transcriptomic timecourse of heat stress in Stylophora pistillata, from bleaching to recovery 🪸🌊 This project was spearheaded by Shani Levy and carried through in @arnausebe.bsky.social's lab at @crg.eu. www.biorxiv.org/content/10.6...
Stylophora pistillata colony from the Red Sea. Picture by Hagai Nativ.
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Arnau Sebé-Pedrós @arnausebe.bsky.social · 20/07/2026
The third chapter in our coral single-cell trilogy is here. After mapping cell type diversity in Stylophora (Levy 2021) and exploring facultative symbiosis in Oculina (Levy 2025), we now uncover cell type-specific responses to heat stress. Find out more in @xgrau.bsky.social's thread below.
biorxiv.org
Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery
Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...
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UCL Research Department of Cell & Developmental Biology @ucl-cdb.bsky.social · 09/07/2026
📢 We're hiring! The Cell & Developmental Biology department (CDB) and other departments in Bioscience @ UCL are delighted to be recruiting for several Lecturer / Associate Professor positions. 👉 View full details and apply here: www.ucl.ac.uk/life-science...
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Sergio Menchero @sermenchero.bsky.social · 08/07/2026
The 2nd part of my postdoc is now out as a preprint! A challenging but fulfilling team effort to perform genome editing in opossums. We found that the lncRNA RSX is essential to initiate X-inactivation in marsupials 🦘 A long-standing question since the discovery that Xist is absent in marsupials 👇
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Xavier Grau-Bové 🌾 @xgrau.bsky.social · 19/06/2026
Do you work with scRNAseq data in non-model organisms that have less-than-stellar gene annotations? ✨ 🧬 You might be interested in GeneExt, a nifty little tool by @zolotarg.bsky.social in @arnausebe.bsky.social's lab, published in #Bioinformatics earlier this year. #singlecell #transcriptomics
academic.oup.com
GeneExt: a gene model extension tool for enhanced single-cell RNA-seq analysis
AbstractMotivation. Incomplete gene models negatively impact single-cell gene expression quantification. This is particularly true in non-model species whe
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James Briscoe @jamesbriscoe.bsky.social · 19/06/2026
In our latest editorial @amjeve.uk & I take on the dreaded impact factor Like Monday mornings no one likes them but you can't ignore them & they keep coming around However there are things we should all do as authors, reviewers & editors journals.biologists.com/dev/article/...
journals.biologists.com
The elephant in the room: impact factor
Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...
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Heng Li @lh3lh3.bsky.social · 16/06/2026
Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357
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Allan Carrillo-Baltodano @allancarbal.bsky.social · 05/06/2026
Poster ready for #EED2026 🏴󠁧󠁢󠁳󠁣󠁴󠁿🪱🏴󠁧󠁢󠁳󠁣󠁴󠁿
Poster for a scientific conference, titled "A single-cell approach to study axial patterning in Annelids" and the list of coauthors.
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MwahahahahahadScientist @mads100tist.bsky.social · 30/05/2026
Academic life is this, with grants and papers
Moe kicking out Barney from the Tavern, looking done and suspicious, then Barney is back in the Tavern behind him
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Alex de Mendoza @alexdemendoza.bsky.social · 26/05/2026
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
biorxiv.org
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Diego Safian @diegosafian.bsky.social · 20/05/2026
Any chance to watch online?? 😅
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Chema Martin @chemamd.bsky.social · 19/05/2026
🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently. www.biorxiv.org/content/10.6...
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Kirsty Grainger @kirstygrainger.bsky.social · 14/05/2026
If you have a BBSRC Early Independence Fellowship outline in, check your inbox. Please give professional services teams a few days to design demand management processes as we're finding out the same time as you. The outlines per institute data provided is super interesting; 15 awards available 👀👀👀👀
UKRI – Biotechnology and Biological Sciences Research Council
Annex A – Maximum Number of Applications to the 2026 round of the BBSRC Early Independence Fellowship scheme per HEI
These figures have been calculated based on submissions to the 2021 Research Excellence Framework (REF) with the number of Early Independence BBSRC Fellowship applications permitted related to the FTE staff numbers included within each institutions REF submission as follows:
Academic organisations who did not submit to the REF and are not identified within the grouping are permitted to submit one application to this opportunity.

Table































































































































UKRI – Biotechnology and Biological Sciences Research Council		
		
Annex A – Maximum Number of Applications to the 2026 round of the BBSRC Early Independence Fellowship scheme per HEI		
		
These figures have been calculated based on submissions to the 2021 Research Excellence Framework (REF) with the number of Early Independence BBSRC Fellowship applications permitted related to the FTE staff numbers included within each institutions REF submission as follows:		
		
Academic organisations who did not submit to the REF and are not identified within the grouping are permitted to submit one application to this opportunity.		
		
		
		
Table		
		
Higher Education Institution (HEI)	Number of outline applications	Maximum number of applications to this opportunity
Aberystwyth University	8	1
Aston University	4	1
Babraham Institute	1	1
Brunel University London	1	1
Cardiff University	8	2
Cranfield University	4	1
Durham University	5	1
Earlham Institute	1	1
Edge Hill University	2	1
Harper Adams University	3	1
Heriot-Watt University	3	1
Imperial College London	27	2
Institute of Cancer Research	3	1
James Hutton Institute	1	1
John Innes Centre	3	1
King's College London	28	2
Lancaster University	3	1
Leeds Beckett University	1	1
London School of Hygiene…UKRI – Biotechnology and Biological Sciences Research Council		
		
Table		
		
Higher Education Institution (HEI)	Number of outline applications	Maximum number of applications to this opportunity
Northumbria University	1	1
Nottingham Trent University	2	1
Oxford Brookes University	1	1
Quadram Institute Bioscience	8	1
Queen Mary University of London	7	1
Queen’s University Belfast	7	1
Rosalind Franklin Institute	1	1
Rothamsted Research	3	1
Royal Botanic Gardens, Kew	4	1
Royal Veterinary College	4	1
Scottish Universities Environmental Research Centre	1	1
Swansea University	2	1
The Francis Crick Institute	5	1
University College London	34	3
University of Aberdeen	2	1
University of Bath	5	1
University of Birmingham	30	2
University of Bradford	1	1
University of Bristol	13	2
University of Cambridge	57	3
University of Dundee	4	1
University of East Anglia	2	1
University of Edinburgh	22	3
University of Essex	2	1
University of Exeter	16	1
University of Glasgow	21	1
University of Hull	2	1
University of Leeds	13	2
University of Leicester	7	1
University of Lincoln	1	1
University of Liverpool	12	1
University of Manchester	25	3
University of Nottingham	11	2
University of Oxford	56	3
University of Plymouth	3	1
University of Reading	8	1

UKRI – Biotechnology and Biological Sciences Research Council		
		
Table		
		
Higher Education Institution (HEI)	Number of outline applications	Maximum number of applications to this opportunity
University of Sheffield	8	2
University of Southampton	13	1
University of St Andrews	4	1
University of Stirling	1	1
University of Strathclyde	3	1
University of Surrey	4	1
University of Sussex	1	1
University of Warwick	10	1
University of York	9	1
Wellcome Sanger Institute	4	1
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Rob Waterhouse @rmwaterhouse.bsky.social · 03/05/2026
Error-corrected ONT reads can lower sequencing costs and improve the quality of #genomic analyses www.nature.com/articles/s41...
nature.com
Telomere-to-Telomere Assembly Using HERRO-Corrected Simplex Nanopore Reads - Nature
Nature - Telomere-to-Telomere Assembly Using HERRO-Corrected Simplex Nanopore Reads
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Berta Verd @bertaverd.bsky.social · 21/04/2026
New Pre-Print Alert! Evolving initial conditions: an alternative developmental route to morphological diversity with Shannon Taylor and @jamesehammond.bsky.social www.biorxiv.org/content/10.6...
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Manuel Irimia @mirimiam.bsky.social · 20/04/2026
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...
biorxiv.org
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Vengamanaidu Modepalli @venky-vnm.bsky.social · 20/04/2026
Interested in miRNAs, early animal evolution, and RNA biology? We’re recruiting a BBSRC-funded Postdoctoral Research Associate @bristolbiosci.bsky.social #Postdoc #microRNA #RNAbiology Apply by 14 May 2026. 👉 www.bristol.ac.uk/jobs/find-in...
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Mark O. Martin @markowenmartin.bsky.social · 03/04/2026
Perspective helps a little.
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Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 02/04/2026
This looks very cool 😎 🔗 to download: github.com/RegenImm-Lab...
github.com
GitHub - RegenImm-Lab/Novabrowse: Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative gen...
Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative genomics tool for multi-species or...
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Daniel Gomez Isaza @danielgomezisaza.bsky.social · 20/03/2026
🔥 New paper out now! Do ectotherms actually adjust their physiology to cope with daily temperature swings? Our latest meta-analysis suggests… not really. Check it out now: doi.org/10.1098/rstb... and the other great studies in this special issues on #EmbracingVariability #PhilTransB#ThermalBiology
doi.org
Unresponsive to change: Ectotherms fail to adjust physiology to daily temperature variation
Abstract. Daily temperature fluctuations are a ubiquitous feature of natural environments, yet our understanding of how ectotherms respond to thermal varia
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Florent Murat @f-murat.bsky.social · 11/03/2026
Our lab is hiring a postdoctoral researcher with expertise in bioinformatics, evolutionary genomics and single-cell data analyses, to explore the evolution of reproductive organs across fishes. We are located in Rennes, France (INRAE-LPGP). For more details: florentmuratwebpage.wordpress.com
florentmuratwebpage.wordpress.com
Florent Murat
Fish Evolution, Genomes, and Reproduction
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Leon Hilgers @leonhilgers.bsky.social · 10/03/2026
I hear you want novelty🦎->🐢, chromosome evolution 🧬, sex determination🩷, link population history📈 & climate🌏🌡️? Or you share my love for wonderfully weird animals? Side-necked turtle genomes reveal chromosomal dynamics, skeletal innovation and cancer resistance www.biorxiv.org/content/10.6... A 🧵
Chelodina longicollis, Eastern Long-necked Turtle. Melbourne Museum. 
Photographer: David Paul, Source: Museums Victoria
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Allan Carrillo-Baltodano @allancarbal.bsky.social · 04/03/2026
New from @chemamd.bsky.social lab @qmulsbbs.bsky.social Collab with Elaine Seaver, @baxevanislab.bsky.social @neva-meyer.bsky.social @abhinavsur.bsky.social New chromosome-level assembly for Capitella teleta 🪱 academic.oup.com/gbe/advance-... #DevBio #WormWednesday @genomebiolevol.bsky.social
Figure showing 3 panels,(A) a picture of annelid Capitella teleta on black background, (B) a cladogram with major biological model organisms showing the phylogenetic position of C. teleta and (C) schematics of the 10 chromosomes of C. teleta
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Darío Lupiáñez @dariloops.bsky.social · 06/03/2026
🚨 Job Alert - Please share! 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! We’re recruiting: ✅ PhD students ✅ Postdocs 💻🧪 Experimental or computational backgrounds welcome 👇 Details below
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Nature Ecology & Evolution @natecoevo.nature.com · 04/03/2026
New Review 👇 The molecular evolution of vertebrate organs: www.nature.com/articles/s41... Margarida Cardoso-Moreira discusses rates of evolution of organs and cell types, molecular mechanisms of organ evolution and how complex traits contributed to the diversification of vertebrates.
nature.com
The molecular evolution of vertebrate organs - Nature Ecology & Evolution
This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms of organ evolution and how complex tr...
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James Briscoe @jamesbriscoe.bsky.social · 02/03/2026
New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...
journals.biologists.com
Preprint Editors – Development's next step into the preprint landscape
Summary: This Editorial announces a call for Preprint Editors in Development to help expand the journal's relationship with preprints by curating our ‘In preprints’ articles.
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Margarida Cardoso Moreira @margaridamcm.bsky.social · 25/02/2026
Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜
rdcu.be
The molecular evolution of vertebrate organs
Nature Ecology & Evolution - This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms...
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