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Ferdinand Marlétaz

@ferdix.bsky.social
387 followers 429 following 21 posts

Comparative and regulatory genomics. Animal phylogeny and evolution

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Reposted by Ferdinand Marlétaz
Aaron Becker @aaronjbecker.bsky.social · 29/09/2026
The average colour of Europe, one day at a time for two years. Scandinavia and the Alps turn white every winter, the green rolls north through spring, and Spain, Italy and Greece bake gold all summer. Data: NASA MODIS, Eurostat GISCO #dataviz #maps #Europe
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CNRS @cnrs.fr · 27/09/2026
Les chauves-souris présentent l’une des plus incroyables trajectoires d’évolution chez les mammifères. On en connaît plus de 1500 espèces ! Comment cette diversité est-elle apparue ? Pour le savoir, direction les grottes et les forêts de Trinité-et-Tobago. Reportage avec lemonde.fr
lejournal.cnrs.fr
Les chauves-souris, laboratoires de l’évolution
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Alex de Mendoza @alexdemendoza.bsky.social · 25/09/2026
For those of you who, like me, missed the Vatican #EvoDevo: www.pas.va/en/events/20..., don't worry, there will be a more earthly local version next week (Friday) in Cambridge Dept of Zoology, program here: londonevodevo.co.uk. Can't promise cardinal vestments in the background though.
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Ferdinand Marlétaz @ferdix.bsky.social · 24/08/2026
Glad to report the release/publication of PESCI, an efficient tools implementing ICC for interspecfic comparison of single cell dataset developped by #Eliseparey in the lab with the help of #laurapiovani github.com/eparey/pesci doi.org/10.1093/bioi...
doi.org
Pesci: fast and user-friendly software to compare single-cell gene expression across species
AbstractSummary. Recent technological advances have propelled comparative functional genomics into the single-cell era, spurring a rapid development of met
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Springer Nature @springernature.com · 20/08/2026
An orange-tailed marsh dart damselfly peering through a leaf has won the 2026 BMC Ecology and Evolution and BMC Zoology image competition. The annual contest showcases the beauty of biodiversity and the science behind its conservation: spklr.io/63325ERtjJ #envecon #biodiversity
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Alex de Mendoza @alexdemendoza.bsky.social · 06/08/2026
The #LondonEvoDevo goes to Cambridge! Kindly hosted by @emiliapsantos.bsky.social, mark on your calendars *October 2nd* at the Main Theatre in the Department of Zoology (Cambridge). Registration (£0.00): docs.google.com/forms/d/e/1F.... All welcome to present: #PI #PhD #PostDocs, submit abstracts!
docs.google.com
LondonEvoDevo meeting - October 2026
This event will take place on Friday October 2nd, 2026, at the Department of Zoology (Main Lecture Theatre), University of Cambridge, Downing Street CB2 3EJ, 12:30 - 18:30. There will be no posters, ...
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Alex de Mendoza @alexdemendoza.bsky.social · 03/08/2026
Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵
the indo-pacific bluebottle (Physalia utriculus)
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genikhovich.bsky.social @genikhovich.bsky.social · 18/06/2026
Congratulations to @kremnyovs.bsky.social, @tclebedeva.bsky.social and @hejnol.bsky.social - this is a fantastic paper. www.nature.com/articles/s41... Very happy to have been part of this collaboration.
nature.com
A blastoporal organizer in a ctenophore - Nature
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
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Alex de Mendoza @alexdemendoza.bsky.social · 02/06/2026
Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/
nature.com
Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian - Nature Ecology & Evolution
Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...
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Ryan N. Felice @rnf.bsky.social · 01/06/2026
Hey look: A job! @echinerd.bsky.social and I are looking for a research technician to work on sea urchin development. If you are good at segmenting CT scans and want a chance to work on some super cool organisms, this job here at UCL is for you! apply now: bit.ly/4o2qccY
CT scan of a juvenile sea urchin
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Elizabeth Beston @elizabethbeston.bsky.social · 23/05/2026
Had a smasheroony time at Walton-on-the-Naze with my fellow microscopy nerds today. I’m putting together a little reel about it. But in the meantime, here’s an amuse bouche… I saw a phoronid larva (horseshoe worm) with tentacles! The first time! #marineplankton 🦑 #zooplankton
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Raphaël Clément @raphclement.bsky.social · 22/05/2026
Our work on Trichoplax locomotion and mechanosensing capabilities is out now in @currentbiology.bsky.social. Congrats Marvin Leria & all co-authors! authors.elsevier.com/c/1n8Ig3QW8S...
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Chema Martin @chemamd.bsky.social · 19/05/2026
🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently. www.biorxiv.org/content/10.6...
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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · 06/05/2026
Please join the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination in Roscoff, France. Deadline for abstract submission extended to May 20, 2026. cjm.sb-roscoff.fr/en/conferenc...
cjm.sb-roscoff.fr
The mechanistic and evolutionary basis of programmed DNA elimination | CNRS - Conférences Jacques Monod (CJM)
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Schmidt Ocean Institute @schmidtocean.bsky.social · 04/05/2026
What do shrimp see? “These guys have completely different eye designs,” according to Dr. Jan Hemmi, a visual neurobiologist. Their large eye size tells Dr. Hemmi and his colleagues that eyes are pretty important to these animals. #designingthefuture3 Read more: www.linkedin.com/feed/update/...
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Secret Mode - Chained Together 2v2 Race OUT NOW! @wearesecretmode.com · 26/04/2026
Did you know that today is #InternationalCrabDay? 🦀 Started by The Crab Museum, this holiday encourages people to share photos of crabs so we’d love to see the Crabby Darwins you’ve created in Everything is Crab! Here's one I made earlier…
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Michalis Averof @michalis-averof.bsky.social · 19/04/2026
Finding molecular tags that localise fluorescent proteins to the cell membrane was the goal of our latest paper, now published in Development @dev-journal.bsky.social. The tags act as address labels, sending proteins to the cell membrane, where they highlight the shape and arrangement of cells. 2/9
journals.biologists.com
Targeting the cell membrane in established and emerging model organisms
Summary: Screening a toolkit of diverse membrane-localising tags identifies candidates that efficiently localise proteins to the plasma membrane in a wide range of animals and choanoflagellates.
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Developmental Biology @devbiol.bsky.social · 14/04/2026
#DBfeature #InHoxWeTrust 🪲 Divergent Hox cluster arrangement in horned beetles retain conserved embryonic and adult expression patterns. by Erica Nadolski, Isabel Manley, Sukhmani Gill, Armin Moczek @ericanadolski.bsky.social tinyurl.com/ycxabrh5
Genomic rearrangement of the Hox cluster in a dung beetle species with derived cephalic horn morphology
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Alex de Mendoza @alexdemendoza.bsky.social · 10/04/2026
Last day to submit an abstract! This is a meeting aimed at all career stages, but especially geared on early career scientists (PhD/postdoc), don't feel you need to have a perfectly polished story to present!
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Nicholas Bellono @nbellono.bsky.social · 02/04/2026
Pablo Villar et al discover male octopus mating arms are sensory organs used to find females, navigate internally to the oviduct & deliver sperm. From behavior to structure, these findings offer a framework for how sensory systems shape reproduction & species barriers www.science.org/doi/10.1126/...
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Alex de Mendoza @alexdemendoza.bsky.social · 02/04/2026
Nice opportunity to join QMUL as a PhD student (or postdoc). Lee works on cool insect symbiosis projects, and I am co-supervisor on this one. Don't miss it if you're into microbiome / host-microbe interactions.
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Alex de Mendoza @alexdemendoza.bsky.social · 23/03/2026
May 5th: if you are around London, please join the London #EvoDevo symposium at QMUL / Charterhouse campus, as usual we will have selected talks and post-event 🍻. A warm up for #EED2026 in Glasgow. Registration £0, more info here: londonevodevo.co.uk
londonevodevo.co.uk
LondonEvoDevo
meeting's website
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Andrew Rambaut (🐏🎀) @arambaut.bsky.social · 28/02/2026
So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the “Example...” button for immediate candy and then click every button you can find).
artic-network.github.io
PearTree — Phylogenetic Tree Viewer
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Fabrizio Ghiselli 🧬 🐜🦪 @fghiselli.bsky.social · 04/02/2026
BMC Biology is currently welcoming submissions of original research to the “Genome organization and evolution” Collection, which I am supporting as a Guest Editor. If interested check out the link: www.biomedcentral.com/collections/... Deadline: 26 March #GenomeEvolution @bmc.springernature.com
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imaeso.bsky.social @imaeso.bsky.social · 07/01/2026
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
rdcu.be
Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...
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Camille Berthelot @camilleberthelot.bsky.social · 17/12/2025
Anouk Necsulea, @maelledaunesse.bsky.social and myself are organising a symposium at SMBE this year. Send us all of your abstracts!!
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Lionel Christiaen, PhD (he/him/his) @lionlchristiaen.bsky.social · 08/12/2025
Very happy to see this piece on the Tunicate Ciona published. Grateful to @alexandrejan.bsky.social and @chiaracastelletti.bsky.social for the Illustrations, and to @natmethods.nature.com for the opportunity to showcase our ever emerging model organism www.nature.com/articles/s41...
nature.com
The tunicate Ciona - Nature Methods
The ascidian tunicate Ciona, one of the closest relatives of the vertebrates, inhabits shallow temperate waters in the worldwide ocean. A unique combination of simple stereotyped embryogenesis, regula...
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Alex de Mendoza @alexdemendoza.bsky.social · 18/11/2025
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
nature.com
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
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Christophe Dessimoz @dessimoz.bsky.social · 23/10/2025
Gene annotations matter for downstream analyses: different structural gene-annotation pipelines yield markedly different orthology calls. We compare four strategies across species and argue for standards & QC before inference. Work led by @silviaprietob.bsky.social. Paper: doi.org/10.1093/bioi...
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Yi-Jyun Luo @yjluo.bsky.social · 07/11/2025
Pleased to share our latest paper led by @tomlewin.bsky.social, now out in @currentbiology.bsky.social! We present the first chromosome-level genome of a phoronid and show that shared chromosomal fusions unite phoronids and bryozoans as sister groups. www.cell.com/current-biol...
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Charlie Hebdo @charliehebdo.fr · 01/11/2025
Laurent Joly, historien. « L’union des droites on l’a déjà eue, c’est le gouvernement de Vichy »
charliehebdo.fr
Laurent Joly, historien. « L’union des droites on l’a déjà eue, c’est le gouvernement de Vichy »
Charlie Hebdo : Vous écrivez dans votre conclusion que la digue entre l’extrême droite pétainiste et la droite républicaine pourrait bientôt céder. Quels en sont les signaux ?Laurent Joly : Cette digue s’est formée au lendemain de la guerre. La droite nationaliste et l’extrême droite, compromises dans Vichy et le collaborationnisme, étaient complètement délégitimées après […]
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Alex de Mendoza @alexdemendoza.bsky.social · 20/10/2025
Come join the #LondonEvoDevo network half day meeting, hosted at @ucl.ac.uk on Friday November 7th, 2025. Submit your abstract by Oct 27th (or your interest in joining) here: forms.gle/TRbdrCkQTcY2.... Friendly vibes and free registration. More info here: londonevodevo.co.uk.
londonevodevo.co.uk
LondonEvoDevo
meeting's website
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Quanta Magazine @quantamagazine.org · 08/10/2025
Adding loops into a genome is a complicated and costly business for a cell. New findings suggest that it may be the reason that ancient life became complex. @philipcball.bsky.social reports: www.quantamagazine.org/loops-of-dna...
quantamagazine.org
Loops of DNA Equipped Ancient Life To Become Complex | Quanta Magazine
New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.
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Alex de Mendoza @alexdemendoza.bsky.social · 14/08/2025
Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate. It is an honour to have contributed to this 20y struggle ⛰️.
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Nature @nature.com · 13/08/2025
A genome sequence and single-cell atlas of a marine worm species point towards bursts of gene emergence, duplication and loss as the drivers of lineage-specific body traits go.nature.com/4oAI2nf
go.nature.com
The perplexing body plan of arrow worms decoded
A genome sequence and single-cell atlas of a marine worm species point towards bursts of gene emergence, duplication and loss as the drivers of lineage-specific body traits.
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Queen Mary School of Biological and Behavioural Sciences @qmulsbbs.bsky.social · 13/08/2025
New Nature study (co-authored by Queen Mary researchers) reveals that arrow worms evolved unique organs by inventing brand-new genes — not just reusing old ones. 🧬🌊 🔗 www.qmul.ac.uk/sbbs/news/it... @qmulse.bsky.social
qmul.ac.uk
Cracking the Genetic Code of Arrow Worms: How Chaetognaths Got Their Unique Body Plan
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Ferdinand Marlétaz @ferdix.bsky.social · 13/08/2025
After nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41... with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
nature.com
The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...
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Nature @nature.com · 31/07/2025
This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered
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Eileen Furlong @eileen-furlong.bsky.social · 30/07/2025
To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
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Alex de Mendoza @alexdemendoza.bsky.social · 28/07/2025
Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7
academic.oup.com
Repressive cytosine methylation is a marker of viral gene transfer across divergent eukaryotes
Abstract. Cytosine DNA methylation patterns vary widely across eukaryotes, with its ancestral roles being understood to have included both transposable ele
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Sergio Menchero @sermenchero.bsky.social · 24/07/2025
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
cell.com
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...
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Max Telford @maxjtelford.bsky.social · 11/07/2025
Is the deuterostome clade an artifact??? New paper with first author @anaserrasilva.bsky.social, Laura Piovani, Paschalis Natsidis and project co-led by Paschalia Kapli. www.sciencedirect.com/science/arti...
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Trends in Genetics @cp-trendsgenetics.bsky.social · 10/07/2025
"Animal origins: Looping back in time" by Omar Matar & Ferdinand Marlétaz (@ferdix.bsky.social) This is a Spotlight on new work that helps answer the question, "how did the chromatin folding mechanisms controlling gene regulation emerge during animal evolution?" Check it out: rb.gy/k53o8p
Figure 1. Evolution and diversity of chromatin three-dimensional architecture at the chromosomal compartment level (A/B) and at the loop and domains level.
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Allan Carrillo-Baltodano @allancarbal.bsky.social · 10/07/2025
Tomorrow we'll welcome the EvoDevo community from UK and beyond @qmulsbbs.bsky.social @qmulse.bsky.social , organised by @chemamd.bsky.social @margaridamcm.bsky.social @ferdix.bsky.social @alexdemendoza.bsky.social , Roman Arguello and James Difrisco. Poster by former lab member Giacomo Mogglioli
Poster of the 2025 UK EvoDevo meeting in London. Drawings show the development of a tea cup
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こまちみゆた @comatimiyuta.bsky.social · 26/06/2025
怪虫図
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Imran Rahman @imranrahman.bsky.social · 26/06/2025
Delighted to share our paper in @currentbiology.bsky.social iology.bsky.social‬ with a palaeo-evo-devo perspective on the evolution of symmetry in echinoderms. Led by Steffi Woodgate with Frankie Dunn, @echinerd.bsky.social, @laurentformery.bsky.social & Sam Zamora www.cell.com/current-biol...-5
cell.com
A new Cambrian stem-group echinoderm reveals the evolution of the anteroposterior axis
Woodgate et al. describe a new bilaterally symmetrical echinoderm, Atlascystis acantha, from the Cambrian of Morocco. Comparisons of plate growth with other echinoderms reveal that Atlascystis possess...
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Chris Mah @echinoblog.bsky.social · 24/06/2025
Whoa. Stunning Man o War- Physalia image via @K_theHermit
stinging tentacles from a man o war-Physalia sp
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ATLASea @atlasea.bsky.social · 21/06/2025
ATLASea Mission – Day 6 In the dissection room, the final sampling steps are underway 🔬 Tissue fragments are collected, labeled, weighed, and logged into a data sheet for full traceability ❄️ Samples are flash-frozen in liquid nitrogen at -196°C to preserve DNA quality for sequencing at Genoscope
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Uri Frank @thecocodium.bsky.social · 20/06/2025
I am looking for a new postdoc to join the lab. Interested in pluripotency, germ cells, and in investigating these in a genetically tractable cnidarian? Get in touch! We offer a long-term contract, excellent research environment, and a lovely city #Galway. www.urifranklab.org
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