iiinova — where your digital self keeps evolving

Reposted by Davies Lab

James Davies @jojdavies.bsky.social · 07/10/2026

Delighted to see our latest paper out in @natgenet.nature.com ! The brilliant @jhamley98.bsky.social developed MCCv, allowing chromatin architecture to be visualised at base-pair resolution for each allele—a powerful way to identify functional genetic variants. www.nature.com/articles/s41... 🧵

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Rob Beagrie @rbeagrie.bsky.social · 19/02/2026

New preprint from @anadopico.bsky.social (who I have had the great pleasure of supervising with Tom Milne) and our fantastic collaborators in the @davieslab.bsky.social www.biorxiv.org/content/10.6... #genomics #GeneRegulation #chromatin

A pictographic model of chromatin folding in the nucleus. DNA wrapped around nucleosomes aggregates into nanoscale domains, whilst newly nucleosome depleted DNA that forms after acute degradation of FACT projects from these domains and engages in long-range interactions that can span TAD boundaries

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Reposted by Davies Lab

Roman Doll @romanmdoll.bsky.social · 20/12/2025

Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

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James Davies @jojdavies.bsky.social · 01/12/2025

Thanks so much for highlighting our images created with @rcollepardo.bsky.social

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MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 06/11/2025

#WIMMReads: Oxford scientists, led by James Davies at the MRC WIMM, have captured the genome’s structure in unprecedented detail. 🧪 Read the full story below 👇 @ox.ac.uk @davieslab.bsky.social @jojdavies.bsky.social @medsci.ox.ac.uk

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 10/07/2025

Our new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social

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Davies Lab @davieslab.bsky.social · 27/08/2025

We’re really excited to see Hangpeng Li present our latest work at the CSH Mechanisms of Eukaryotic Transcription meeting.

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Nature Biotechnology @natbiotech.nature.com · 26/08/2025

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

nature.com

Children with rare genetic diseases get CRISPR Cures center - Nature Biotechnology

Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center

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Beth Psaila @bethpsaila.bsky.social · 15/08/2025

Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

science.org

By sucking up DNA, clot-producing platelets could help diagnose cancer

The cells could be a new source of tumor DNA for liquid biopsies

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Reposted by Davies Lab

James Zou @jameszou.bsky.social · 29/07/2025

⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41... We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.

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Oxford Biochemistry @oxfordbiochemistry.bsky.social · 23/07/2025

Great news for the Advanced Proteomics Facility based here in Biochemistry @ox.ac.uk ! The Wolfson Foundation is supporting the acquisition of a state-of-the-art mass spectrometer – the first of its kind in the UK – opening up possibilities for breakthroughs in human health ⬇️ bit.ly/202507-apf

bit.ly

£840,000 award from the Wolfson Foundation to enhance Oxford’s proteomics research

State-of-the-art mass spectrometer to be installed at the University’s Advanced Proteomics Facility (APF)

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