The primary cilium is a microtubule-based sensory organelle projecting from the plasma membrane of most mammalian cells. Genetic defects in ciliary components cause chronic kidney disease (CKD) charac...

Nephronophthisis (NPH) is n rare recessive kidney disease caused by biallelic variants in more than 25 NPHP genes encoding proteins that localize to primary cilia. It is characterized by three differe...

14TH ANNUAL MEETING ON CILIA, FLAGELLA AND CENTROSOMES

Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome.

In this perspective article, Thomsen et al. discuss how primary cilia coordinate neocortical development, function, and regeneration. They highlight emerging links between ciliary control of neural pr...

Proteinuria causes ciliary elongation and actin cytoskeleton remodeling, revealing a key mechanism in kidney disease progression.

CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and directional retrieval of polyubiquitinated proteins from cilia, a process essential for m...

A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.

The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...

In Trypanosoma brucei, IFT trains selectively associate with specific axonemal microtubules. Using advanced microscopy, Araujo Alves et al. reveal how this

Primary cilium senses mechanical cues to regulate young neuron migration via GPR161 signaling.

Nephronophthisis (NPH) is a renal ciliopathy characterized by chronic tubulointerstitial fibrosis. Despite discovery of multiple disease genes, mechanisms of NPH-associated kidney degeneration remain ...

Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development …

In these days of political instability, geopolitical tensions, and social discontent around the world, there are continued threats to the principles, conduct, and findings of science. This assault on ...